TM2S_SOLLC
ID TM2S_SOLLC Reviewed; 861 AA.
AC Q71BH1; A0A3Q7I1U1; C3UZH5; C3UZI0; Q5UB82;
DT 11-DEC-2019, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=ToMV susceptible protein tm-2 {ECO:0000303|PubMed:14558663};
DE AltName: Full=Disease susceptible protein tm-2 {ECO:0000303|Ref.4};
GN Name=tm-2 {ECO:0000303|PubMed:14558663, ECO:0000303|Ref.3};
GN OrderedLocusNames=Solyc09g018220 {ECO:0000305};
OS Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum;
OC Solanum subgen. Lycopersicon.
OX NCBI_TaxID=4081;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC STRAIN=cv. ATV840, cv. Craigella GCR26, and cv. Stevens;
RX PubMed=14558663; DOI=10.1023/a:1025434519282;
RA Lanfermeijer F.C., Dijkhuis J., Sturre M.J.G., de Haan P., Hille J.;
RT "Cloning and characterization of the durable tomato mosaic virus resistance
RT gene Tm-2(2) from Lycopersicon esculentum.";
RL Plant Mol. Biol. 52:1037-1049(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Heinz 1706;
RX PubMed=22660326; DOI=10.1038/nature11119;
RG Tomato Genome Consortium;
RT "The tomato genome sequence provides insights into fleshy fruit
RT evolution.";
RL Nature 485:635-641(2012).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-17.
RC STRAIN=cv. ATV840;
RA Lanfermeijer F.C., ten Hoopen F., Hille J.;
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 228-423 AND 594-827.
RC STRAIN=cv. Anahu LA0655, cv. LA0656, and cv. Peto 95-43 LA3528;
RA Shi A., Vierling R., Grazzini R., Hogue P., Miller K.;
RT "Development of SNP markers for disease resistance genes in tomato.";
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION.
RC STRAIN=cv. Craigella GCR26;
RX PubMed=2535549; DOI=10.2307/3868972;
RA Meshi T., Motoyoshi F., Maeda T., Yoshiwoka S., Watanabe H., Okada Y.;
RT "Mutations in the tobacco mosaic virus 30-kD protein gene overcome Tm-2
RT resistance in tomato.";
RL Plant Cell 1:515-522(1989).
RN [6]
RP GENE FAMILY.
RC STRAIN=cv. Craigella GCR26;
RX PubMed=24173917; DOI=10.1007/bf00221969;
RA Ohmori T., Murata M., Motoyoshi F.;
RT "Identification of RAPD markers linked to the Tm-2 locus in tomato.";
RL Theor. Appl. Genet. 90:307-311(1995).
RN [7]
RP FUNCTION.
RC STRAIN=cv. Craigella GCR26;
RX PubMed=9612948; DOI=10.1094/mpmi.1998.11.6.498;
RA Weber H., Pfitzner A.J.P.;
RT "Tm-2(2) resistance in tomato requires recognition of the carboxy terminus
RT of the movement protein of tomato mosaic virus.";
RL Mol. Plant Microbe Interact. 11:498-503(1998).
RN [8]
RP FUNCTION.
RC STRAIN=cv. Craigella GCR26;
RX PubMed=15290376; DOI=10.1007/s00705-004-0312-0;
RA Weber H., Ohnesorge S., Silber M.V., Pfitzner A.J.P.;
RT "The Tomato mosaic virus 30 kDa movement protein interacts differentially
RT with the resistance genes Tm-2 and Tm-2(2).";
RL Arch. Virol. 149:1499-1514(2004).
RN [9]
RP FUNCTION, AND GENE FAMILY.
RC STRAIN=cv. Craigella GCR26;
RX PubMed=16172136; DOI=10.1093/jxb/eri288;
RA Lanfermeijer F.C., Warmink J., Hille J.;
RT "The products of the broken Tm-2 and the durable Tm-2(2) resistance genes
RT from tomato differ in four amino acids.";
RL J. Exp. Bot. 56:2925-2933(2005).
RN [10]
RP FUNCTION.
RC STRAIN=cv. Monalbo;
RX PubMed=29018314; DOI=10.5423/ppj.nt.04.2017.0082;
RA Sihelska N., Vozarova Z., Predajna L., Soltys K., Hudcovicova M.,
RA Mihalik D., Kraic J., Mrkvova M., Kudela O., Glasa M.;
RT "Experimental infection of different tomato genotypes with tomato mosaic
RT virus led to a low viral population heterogeneity in the capsid protein
RT encoding region.";
RL Plant Pathol. J. 33:508-513(2017).
RN [11]
RP INTERACTION WITH TOBACCO MOSAIC VIRUS MOUVEMENT PROTEIN (MICROBIAL
RP INFECTION).
RX PubMed=28258211; DOI=10.1104/pp.16.01512;
RA Chen T., Liu D., Niu X., Wang J., Qian L., Han L., Liu N., Zhao J.,
RA Hong Y., Liu Y.;
RT "Antiviral resistance protein Tm-2(2) functions on the plasma membrane.";
RL Plant Physiol. 173:2399-2410(2017).
CC -!- FUNCTION: Potential inhibitor of viral mouvements which may confer
CC resistance to some tobamoviruses but not to the tomato mosaic virus
CC (ToMV) and tobacco mosaic virus (TMV). {ECO:0000269|PubMed:14558663,
CC ECO:0000269|PubMed:15290376, ECO:0000269|PubMed:16172136,
CC ECO:0000269|PubMed:2535549, ECO:0000269|PubMed:29018314,
CC ECO:0000269|PubMed:9612948}.
CC -!- SUBUNIT: (Microbial infection) Fails to interact with the tobamovirus
CC mouvement protein of tobacco mosaic virus (TMV).
CC {ECO:0000269|PubMed:28258211}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q71BG9};
CC Peripheral membrane protein {ECO:0000250|UniProtKB:Q71BG9}; Cytoplasmic
CC side {ECO:0000250|UniProtKB:Q71BG9}.
CC -!- MISCELLANEOUS: The Tm-2, Tm-2(2) and Tm-2nv alleles present in the
CC tomato mosaic virus (ToMV/TMV)-resistant tomato cv. Craigella isolates
CC GCR236 (AC Q71BH0), cv. Craigella GCR267 (AC Q71BG9) and cv. Yukang 2
CC (AC Q5MLE9), respectively confers resistance to ToMV but not the tm-2
CC allele present in the ToMV-susceptible tomato cv. Craigella isolate
CC GCR26 (AC Q71BH1). {ECO:0000269|PubMed:14558663}.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF536199; AAQ10734.1; -; Genomic_DNA.
DR EMBL; CM001072; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AY765396; AAV39530.1; -; Genomic_DNA.
DR EMBL; FJ817595; ACO52368.1; -; Genomic_DNA.
DR EMBL; FJ817596; ACO52369.1; -; Genomic_DNA.
DR EMBL; FJ817599; ACO52372.1; -; Genomic_DNA.
DR EMBL; FJ817600; ACO52373.1; -; Genomic_DNA.
DR EMBL; FJ817601; ACO52374.1; -; Genomic_DNA.
DR EMBL; FJ817607; ACO52380.1; -; Genomic_DNA.
DR RefSeq; NP_001318061.1; NM_001331132.1.
DR AlphaFoldDB; Q71BH1; -.
DR SMR; Q71BH1; -.
DR STRING; 4081.Solyc09g018220.1.1; -.
DR PaxDb; Q71BH1; -.
DR PRIDE; Q71BH1; -.
DR GeneID; 101255420; -.
DR KEGG; sly:101255420; -.
DR eggNOG; KOG4658; Eukaryota.
DR HOGENOM; CLU_000837_25_4_1; -.
DR InParanoid; Q71BH1; -.
DR OrthoDB; 133906at2759; -.
DR PhylomeDB; Q71BH1; -.
DR Proteomes; UP000004994; Unplaced.
DR ExpressionAtlas; Q71BH1; baseline and differential.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0098542; P:defense response to other organism; IEA:UniProt.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.8.430; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; PTHR23155; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 1: Evidence at protein level;
KW ATP-binding; Cell membrane; Coiled coil; Leucine-rich repeat; Membrane;
KW Nucleotide-binding; Plant defense; Reference proteome; Repeat.
FT CHAIN 1..861
FT /note="ToMV susceptible protein tm-2"
FT /id="PRO_0000448718"
FT DOMAIN 162..388
FT /note="NB-ARC"
FT /evidence="ECO:0000255"
FT REPEAT 225..248
FT /note="LRR 1"
FT /evidence="ECO:0000255"
FT REPEAT 305..327
FT /note="LRR 2"
FT /evidence="ECO:0000255"
FT REPEAT 388..411
FT /note="LRR 3"
FT /evidence="ECO:0000255"
FT REPEAT 449..472
FT /note="LRR 4"
FT /evidence="ECO:0000255"
FT REPEAT 510..536
FT /note="LRR 5"
FT /evidence="ECO:0000255"
FT REPEAT 585..608
FT /note="LRR 6"
FT /evidence="ECO:0000255"
FT REPEAT 609..631
FT /note="LRR 7"
FT /evidence="ECO:0000255"
FT REPEAT 652..680
FT /note="LRR 8"
FT /evidence="ECO:0000255"
FT REPEAT 689..713
FT /note="LRR 9"
FT /evidence="ECO:0000255"
FT REPEAT 735..758
FT /note="LRR 10"
FT /evidence="ECO:0000255"
FT REPEAT 781..804
FT /note="LRR 11"
FT /evidence="ECO:0000255"
FT REPEAT 810..835
FT /note="LRR 12"
FT /evidence="ECO:0000255"
FT COILED 63..83
FT /evidence="ECO:0000255"
FT BINDING 185..192
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 861 AA; 98338 MW; 56E24DF062BA8E78 CRC64;
MAEILLTSVI NKSVEIAGNL LIQEGKRLYW LKEDIDWLQR EMRHIRSYVD NAKAKEAGGD
SRVKNLLKDI QELAGDVEDL LDDFLPKIQR SNKFNYCLKT SSFADEFAME IEKIKRRVVD
IDRIRKTYNI IDTDNNNDDC VLLDRRRLFL HADETEIIGL DDDFNMLQAK LLNQDLHYGV
VSIVGMPGLG KTTLAKKLYR LIRDQFECSG LVYVSQQPRA GEILLDIAKQ IGLTEQKIKE
NLEDNLRSLL KIKRYVILLD DIWDVEIWDD LKLVLPECDS KVGSRMIITS RNSNVGRYIG
GESSLHALQP LESEKSFELF TKKIFNFDDN NSWANASPDL VNIGRNIAGR CGGIPLAIVV
TAGMLRARER TEHAWNRVLE SMGHKVQDGC AKVLALSYND LPIASRPCFL YFSLYPEDHE
IRAFDLINMW IAEKFIVVNS GNRREAEDLA EDVLNDLVSR NLIQLAKRTY NGRISSCRIH
DLLHSLCVDL AKESNFFHTA HDVFGDPGNV ARLRRITFYS DNVMIEFFGS NPKLEKLRVL
FCFTKDPSIF SHMACFDFKL LHTLVVVMSQ SFQAYVTIPS KFGNMTCLRY LKLEGNICGK
LPNSIVKLTR LETIDIDRRS LIQLPSGVWE SKHLRHLCYR DYGQACNSCF SISSFYPNIY
SLHPNNLQTL MWIPDKFFEP RLLHRLINLR KLGILGVSNS TVKILSTCRP VPKALKVLKL
RFFSDPSEQI NLSSYPKIVK LHLNVDRTIA LNSEAFPPNI IKLTLVCFMV DSCLLAVLKT
LPKLRKLKMV ICKYNEEKMA LSGEANGYSF PQLEVLHIHS PNGLSEVTCT DDVSMPKLKK
LLLTGFHCGI SLSERLKKLS K
