ID   TM35B_HUMAN             Reviewed;         154 AA.
AC   Q8NCS4;
DT   27-JUL-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Transmembrane protein 35B;
DE   AltName: Full=ZMYM6 neighbor protein;
DE   Flags: Precursor;
GN   Name=TMEM35B {ECO:0000312|HGNC:HGNC:40021}; Synonyms=ZMYM6NB;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712; DOI=10.1002/pmic.201400617;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA   Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the DoxX family. {ECO:0000305}.
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DR   EMBL; AC114490; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471059; EAX07432.1; -; Genomic_DNA.
DR   EMBL; BC029439; AAH29439.1; -; mRNA.
DR   CCDS; CCDS53296.1; -.
DR   RefSeq; NP_001182085.1; NM_001195156.1.
DR   AlphaFoldDB; Q8NCS4; -.
DR   BioGRID; 934819; 20.
DR   IntAct; Q8NCS4; 2.
DR   iPTMnet; Q8NCS4; -.
DR   PhosphoSitePlus; Q8NCS4; -.
DR   BioMuta; TMEM35B; -.
DR   DMDM; 74730174; -.
DR   EPD; Q8NCS4; -.
DR   jPOST; Q8NCS4; -.
DR   MassIVE; Q8NCS4; -.
DR   MaxQB; Q8NCS4; -.
DR   PaxDb; Q8NCS4; -.
DR   PeptideAtlas; Q8NCS4; -.
DR   PRIDE; Q8NCS4; -.
DR   ProteomicsDB; 72935; -.
DR   Antibodypedia; 64058; 4 antibodies from 4 providers.
DR   DNASU; 100506144; -.
DR   Ensembl; ENST00000373337.3; ENSP00000362435.3; ENSG00000243749.1.
DR   GeneID; 100506144; -.
DR   KEGG; hsa:100506144; -.
DR   MANE-Select; ENST00000373337.4; ENSP00000362435.3; NM_001195156.2; NP_001182085.1.
DR   UCSC; uc001bye.4; human.
DR   CTD; 100506144; -.
DR   GeneCards; TMEM35B; -.
DR   HGNC; HGNC:40021; TMEM35B.
DR   HPA; ENSG00000243749; Low tissue specificity.
DR   neXtProt; NX_Q8NCS4; -.
DR   VEuPathDB; HostDB:ENSG00000243749; -.
DR   eggNOG; ENOG502RXPR; Eukaryota.
DR   GeneTree; ENSGT00940000154325; -.
DR   HOGENOM; CLU_121618_1_0_1; -.
DR   InParanoid; Q8NCS4; -.
DR   OMA; PVSEQMK; -.
DR   OrthoDB; 1548715at2759; -.
DR   PhylomeDB; Q8NCS4; -.
DR   TreeFam; TF300206; -.
DR   PathwayCommons; Q8NCS4; -.
DR   BioGRID-ORCS; 100506144; 7 hits in 1069 CRISPR screens.
DR   ChiTaRS; TMEM35B; human.
DR   Pharos; Q8NCS4; Tdark.
DR   PRO; PR:Q8NCS4; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q8NCS4; protein.
DR   Bgee; ENSG00000243749; Expressed in placenta and 98 other tissues.
DR   Genevisible; Q8NCS4; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR032808; DoxX.
DR   InterPro; IPR040399; TMEM35A/B.
DR   PANTHER; PTHR13163; PTHR13163; 1.
DR   Pfam; PF13564; DoxX_2; 1.
PE   1: Evidence at protein level;
KW   Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..154
FT                   /note="Transmembrane protein 35B"
FT                   /id="PRO_0000411096"
FT   TRANSMEM        63..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        85..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        112..132
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   154 AA;  16885 MW;  CA551E75A173F1AC CRC64;
     MALLLSVLRV LLGGFFALVG LAKLSEEISA PVSERMNALF VQFAEVFPLK VFGYQPDPLN
     YQIAVGFLEL LAGLLLVMGP PMLQEISNLF LILLMMGAIF TLAALKESLS TCIPAIVCLG
     FLLLLNVGQL LAQTKKVVRP TRKKTLSTFK ESWK