ID   TM39A_BOVIN             Reviewed;         488 AA.
AC   Q0VCF5;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Transmembrane protein 39A;
GN   Name=TMEM39A;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal lung;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulates autophagy by controlling the spatial distribution
CC       and levels of the intracellular phosphatidylinositol 4-phosphate
CC       (PtdIns(4)P) pools (By similarity). Modulates (PtdIns(4)P) levels by
CC       regulating the ER-to-Golgi trafficking of the phosphatidylinositide
CC       phosphatase SACM1L (By similarity). {ECO:0000250|UniProtKB:Q9NV64}.
CC   -!- SUBUNIT: Interacts with SACM1L, SEC23A and SEC24A.
CC       {ECO:0000250|UniProtKB:Q9NV64}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q9NV64}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the TMEM39 family. {ECO:0000305}.
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DR   EMBL; BC120195; AAI20196.1; -; mRNA.
DR   RefSeq; NP_001069828.1; NM_001076360.2.
DR   AlphaFoldDB; Q0VCF5; -.
DR   STRING; 9913.ENSBTAP00000000254; -.
DR   PaxDb; Q0VCF5; -.
DR   Ensembl; ENSBTAT00000000254; ENSBTAP00000000254; ENSBTAG00000000213.
DR   GeneID; 615128; -.
DR   KEGG; bta:615128; -.
DR   CTD; 55254; -.
DR   VEuPathDB; HostDB:ENSBTAG00000000213; -.
DR   VGNC; VGNC:36082; TMEM39A.
DR   eggNOG; KOG3828; Eukaryota.
DR   GeneTree; ENSGT00390000018895; -.
DR   HOGENOM; CLU_028992_0_0_1; -.
DR   InParanoid; Q0VCF5; -.
DR   OMA; PQHLWSE; -.
DR   OrthoDB; 1460710at2759; -.
DR   TreeFam; TF321110; -.
DR   Proteomes; UP000009136; Chromosome 1.
DR   Bgee; ENSBTAG00000000213; Expressed in oocyte and 106 other tissues.
DR   ExpressionAtlas; Q0VCF5; baseline.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:1902902; P:negative regulation of autophagosome assembly; ISS:UniProtKB.
DR   GO; GO:1901097; P:negative regulation of autophagosome maturation; ISS:UniProtKB.
DR   InterPro; IPR019397; Uncharacterised_TMEM39.
DR   PANTHER; PTHR12995; PTHR12995; 1.
DR   Pfam; PF10271; Tmp39; 1.
PE   2: Evidence at transcript level;
KW   Autophagy; Endoplasmic reticulum; Glycoprotein; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..488
FT                   /note="Transmembrane protein 39A"
FT                   /id="PRO_0000279223"
FT   TRANSMEM        72..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        110..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        154..174
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        182..202
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        287..307
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        319..339
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        420..440
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        446..466
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        31
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        39
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   488 AA;  55617 MW;  5375096CF0C68D3F CRC64;
     MPGGRRGPSR QQLSRSALPS LQTLVGGGCG NGTGLRNRNG SAIGLPVPPI TALITPGPVR
     HCQIPDLPVD GSLLFEFLFF IYLLVALFIQ YINIYKTVWW YPYNHPASCT SLNFHLIDYH
     LAAFITVMLA RRLVWALISE ATKAGASSMI HYMVLISARL VLLTLCGWVL CWTLVNLFRS
     HSVLNLLFLG YPFGVYVPLC CFHQDSRAHL LLTDFPYAVQ HQAVEESAST VGGLARSKDF
     LSLLLESLKE QFNNATPIPT HSCPLSPDLI RNEVECLKAD FNHRIKEVLF NSLFSAYYVA
     FLPLCFVKST QYYDMRWSCE HLIMVWINAF VMLTTQLLPS KYCDLLHKSA AHLGKWQKLE
     HGSYSNAPQH IWSENTIWPQ GVLVRHSRCL YRAVGPYNVA VPSDVSHARF YFLFHRPLRL
     LNLLILIEGS VVFYQLYSLL RSEKWNHTLS MALILFCNYY VLFKLLRDRI VLGRAYSYPL
     NSYELKAN