ID   TM39A_DANRE             Reviewed;         481 AA.
AC   Q6PH58;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Transmembrane protein 39A;
GN   Name=tmem39a; ORFNames=zgc:65781;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulates autophagy by controlling the spatial distribution
CC       and levels of the intracellular phosphatidylinositol 4-phosphate
CC       (PtdIns(4)P) pools (By similarity). Modulates (PtdIns(4)P) levels by
CC       regulating the ER-to-Golgi trafficking of the phosphatidylinositide
CC       phosphatase SACM1L (By similarity). {ECO:0000250|UniProtKB:Q9NV64}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q9NV64}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the TMEM39 family. {ECO:0000305}.
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DR   EMBL; BC056707; AAH56707.1; -; mRNA.
DR   RefSeq; NP_955926.1; NM_199632.1.
DR   AlphaFoldDB; Q6PH58; -.
DR   STRING; 7955.ENSDARP00000105757; -.
DR   PaxDb; Q6PH58; -.
DR   GeneID; 323208; -.
DR   KEGG; dre:323208; -.
DR   CTD; 55254; -.
DR   ZFIN; ZDB-GENE-030131-1928; tmem39a.
DR   eggNOG; KOG3828; Eukaryota.
DR   InParanoid; Q6PH58; -.
DR   OrthoDB; 1460710at2759; -.
DR   PhylomeDB; Q6PH58; -.
DR   PRO; PR:Q6PH58; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:1902902; P:negative regulation of autophagosome assembly; ISS:UniProtKB.
DR   GO; GO:1901097; P:negative regulation of autophagosome maturation; ISS:UniProtKB.
DR   InterPro; IPR019397; Uncharacterised_TMEM39.
DR   PANTHER; PTHR12995; PTHR12995; 1.
DR   Pfam; PF10271; Tmp39; 1.
PE   2: Evidence at transcript level;
KW   Autophagy; Endoplasmic reticulum; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..481
FT                   /note="Transmembrane protein 39A"
FT                   /id="PRO_0000279227"
FT   TRANSMEM        74..94
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        109..129
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        182..202
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        278..298
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        313..333
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        411..431
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        437..457
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   481 AA;  54156 MW;  A2E0F1F78F0E9E1D CRC64;
     MPGGRRGPSR QQLSRSALPS LQTLVGGGLS NGAGLRCRSS SAVGLSAPPL TALITPEPVR
     HSRIPDLPLD SNLLFETLLL LYLLVALLVQ YINIYRTVWW SSYSQPTAST SLNFHLMDAH
     LAVFIAVMLS RRLVWTLLSE VCVACPASPL CYVLLLVVRV CVLTLCGWVL CWTLLNLFRS
     HSVLKLLFLG YPFGVYVPLC CLHQDGSPAA DCGFADADGA DGALLQPRDF LTLLRENLRQ
     QLSGTHTHTH THTCPPSPEL IRSEVQQLKT DFNRRIKEVL FNSLLSAYYV AFLPLCFVKS
     TQYYDMRWSC EHLIMVWINA FVMLMSHLLP PHYCDLLHRC AAHLGRWQRL EPGSCSNTPQ
     HTWSDSTIWP QGVLVRHSRC LYKAVGPYNV ALPSDVSHAR FYFLFHKPLR LLNVLIGIEC
     SVVVYQLYSL LRSERWNHTL SLGLILVCNY YVLFKLLRDR LVLGKAYSHP LGSAGLGMKR
     D