ID   TM39A_RAT               Reviewed;         497 AA.
AC   Q5U2V9;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Transmembrane protein 39A;
GN   Name=Tmem39a;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Regulates autophagy by controlling the spatial distribution
CC       and levels of the intracellular phosphatidylinositol 4-phosphate
CC       (PtdIns(4)P) pools (By similarity). Modulates (PtdIns(4)P) levels by
CC       regulating the ER-to-Golgi trafficking of the phosphatidylinositide
CC       phosphatase SACM1L (By similarity). {ECO:0000250|UniProtKB:Q9NV64}.
CC   -!- SUBUNIT: Interacts with SACM1L, SEC23A and SEC24A.
CC       {ECO:0000250|UniProtKB:Q9NV64}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q9NV64}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the TMEM39 family. {ECO:0000305}.
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DR   EMBL; BC085845; AAH85845.1; -; mRNA.
DR   RefSeq; NP_001013887.1; NM_001013865.1.
DR   AlphaFoldDB; Q5U2V9; -.
DR   STRING; 10116.ENSRNOP00000049087; -.
DR   GlyGen; Q5U2V9; 3 sites.
DR   PaxDb; Q5U2V9; -.
DR   PRIDE; Q5U2V9; -.
DR   Ensembl; ENSRNOT00000048738; ENSRNOP00000049087; ENSRNOG00000003075.
DR   GeneID; 288092; -.
DR   KEGG; rno:288092; -.
DR   UCSC; RGD:1306421; rat.
DR   CTD; 55254; -.
DR   RGD; 1306421; Tmem39a.
DR   eggNOG; KOG3828; Eukaryota.
DR   GeneTree; ENSGT00390000018895; -.
DR   HOGENOM; CLU_028992_0_0_1; -.
DR   InParanoid; Q5U2V9; -.
DR   OMA; PQHLWSE; -.
DR   OrthoDB; 1460710at2759; -.
DR   PhylomeDB; Q5U2V9; -.
DR   TreeFam; TF321110; -.
DR   PRO; PR:Q5U2V9; -.
DR   Proteomes; UP000002494; Chromosome 11.
DR   Bgee; ENSRNOG00000003075; Expressed in pancreas and 19 other tissues.
DR   Genevisible; Q5U2V9; RN.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:1902902; P:negative regulation of autophagosome assembly; ISS:UniProtKB.
DR   GO; GO:1901097; P:negative regulation of autophagosome maturation; ISS:UniProtKB.
DR   GO; GO:0045070; P:positive regulation of viral genome replication; ISO:RGD.
DR   InterPro; IPR019397; Uncharacterised_TMEM39.
DR   PANTHER; PTHR12995; PTHR12995; 1.
DR   Pfam; PF10271; Tmp39; 1.
PE   2: Evidence at transcript level;
KW   Autophagy; Endoplasmic reticulum; Glycoprotein; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..497
FT                   /note="Transmembrane protein 39A"
FT                   /id="PRO_0000279226"
FT   TRANSMEM        72..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        110..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        155..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        182..202
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        285..305
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        317..337
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        418..438
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        444..464
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        31
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        39
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        251
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   497 AA;  56790 MW;  C0B2891A8F367B25 CRC64;
     MPSRRRGPSR QQLSRSALPS IQTLVGGGCG NGTGLRNRNG SAIGLPVPPT TALITPGPVR
     HCQIPDLPVD GSLFFEFLFF IYLLIVLFIQ YINIYKTVWW YPYNHPASCT SLNFHLIDYY
     LAAFITVMLA RRLVWALISE ATKAGAASMV HYTALILARL VLLTLCGWVL CWTLVNLFRS
     HSVLNLLFLG YPFGVYVPLY CFHQDSRAHL LLTDYVVQHQ AVEDAASNVG SLTRSKDFLS
     LLLESLKEQF NNSTPIPTHS CPLSPDLIRN EVECLKADFN HRIKDVLFNS LFSAYYVAFL
     PLCFVKSTQY YDMRWSCEHL IMVWINAFVM LTTQLLPSKY CDLLHKSAAH LGKWQKLEHG
     FYSNAPQHIW SENTIWPQGV LVRHSRCLYR AMGPYNVAVP SDGSHARFYF LFHRPLRVLN
     LLILIEGSVI IYQLYSLLRS EKWNHTLSMA LVLFCNYYVL FKLLRDRIVL GRAYSYPSTA
     TDSRQTKLPL SSEGELR