ID   TM39A_XENTR             Reviewed;         488 AA.
AC   Q6GL42;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Transmembrane protein 39A;
GN   Name=tmem39a;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulates autophagy by controlling the spatial distribution
CC       and levels of the intracellular phosphatidylinositol 4-phosphate
CC       (PtdIns(4)P) pools (By similarity). Modulates (PtdIns(4)P) levels by
CC       regulating the ER-to-Golgi trafficking of the phosphatidylinositide
CC       phosphatase SACM1L (By similarity). {ECO:0000250|UniProtKB:Q9NV64}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q9NV64}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the TMEM39 family. {ECO:0000305}.
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DR   EMBL; BC074669; AAH74669.1; -; mRNA.
DR   RefSeq; NP_001004850.1; NM_001004850.1.
DR   AlphaFoldDB; Q6GL42; -.
DR   PaxDb; Q6GL42; -.
DR   DNASU; 448136; -.
DR   GeneID; 448136; -.
DR   KEGG; xtr:448136; -.
DR   CTD; 55254; -.
DR   Xenbase; XB-GENE-5851741; tmem39a.
DR   eggNOG; KOG3828; Eukaryota.
DR   HOGENOM; CLU_028992_0_0_1; -.
DR   InParanoid; Q6GL42; -.
DR   OMA; VWEDERP; -.
DR   OrthoDB; 1460710at2759; -.
DR   PhylomeDB; Q6GL42; -.
DR   TreeFam; TF321110; -.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000023015; Expressed in neurula embryo and 12 other tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:1902902; P:negative regulation of autophagosome assembly; ISS:UniProtKB.
DR   GO; GO:1901097; P:negative regulation of autophagosome maturation; ISS:UniProtKB.
DR   InterPro; IPR019397; Uncharacterised_TMEM39.
DR   PANTHER; PTHR12995; PTHR12995; 1.
DR   Pfam; PF10271; Tmp39; 1.
PE   2: Evidence at transcript level;
KW   Autophagy; Endoplasmic reticulum; Glycoprotein; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..488
FT                   /note="Transmembrane protein 39A"
FT                   /id="PRO_0000279230"
FT   TRANSMEM        72..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        110..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        155..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        182..202
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        287..307
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        319..339
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        420..440
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        446..466
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        31
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        39
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        180
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   488 AA;  55665 MW;  777DCB95F7A670C4 CRC64;
     MPGGRRGPSR QQLSRSALPS LQTLVGGTCG NGTGLRNRNG SAIGLSAPPI TALITPEPVR
     HCHIPELPLD GGLLFEFLFF IYLLVALFIQ YINIYKSVWW YPYNHPASCT SLNFHLIDYH
     LAAFITVMLA RRLVWALISE ASQVGTSSMV HYAALITARL VLLTLCGWVF CWTLVNLFRN
     HSVLNLLFLG YPFGVYVPLC CFHQDSRSQP LPTDCGYLVQ DPLVDDGANG MATLVRPRDF
     LSLLRESLRE QFNSTPSIPS HSCPLSPDLI RNEVECLKAD FNRRIKEVLF NSLFSAYYVA
     FLPLCFVKST QYYDMRWSCE HLIMVWINAF VMLSTQLLPP KYCDLLHRSA SHLGKWQKLE
     HGSYSNAPQH IWSENTVWPQ GVLVRHSRSL YKAVGPYNVA VPSEVSHARF YFLFHRPLRL
     LNLLLIIEGS LVLYQLYSLL RAEKWNHTLS IALILFCNYY VLFKLLRDRI VLGRAYSYPI
     SSYGLKPH