TM39B_HUMAN
ID TM39B_HUMAN Reviewed; 492 AA.
AC Q9GZU3; B4DKN8; B4DQE6; B4DTN8; D3DPP4; Q6IA44;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Transmembrane protein 39B;
GN Name=TMEM39B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4).
RC TISSUE=Colon, Ovary, and Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and analysis of
RT 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- INTERACTION:
CC Q9GZU3-4; Q13113: PDZK1IP1; NbExp=3; IntAct=EBI-17572471, EBI-716063;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q9GZU3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9GZU3-2; Sequence=VSP_056125, VSP_056126;
CC Name=3;
CC IsoId=Q9GZU3-3; Sequence=VSP_056124, VSP_056127, VSP_056128;
CC Name=4;
CC IsoId=Q9GZU3-4; Sequence=VSP_056123;
CC -!- SIMILARITY: Belongs to the TMEM39 family. {ECO:0000305}.
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DR EMBL; AK023331; BAB14530.1; -; mRNA.
DR EMBL; AK296653; BAG59250.1; -; mRNA.
DR EMBL; AK298766; BAG60908.1; -; mRNA.
DR EMBL; AK300293; BAG62050.1; -; mRNA.
DR EMBL; AL136695; CAB66630.1; -; mRNA.
DR EMBL; CR457311; CAG33592.1; -; mRNA.
DR EMBL; CR533536; CAG38567.1; -; mRNA.
DR EMBL; AL445248; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471059; EAX07570.1; -; Genomic_DNA.
DR EMBL; CH471059; EAX07571.1; -; Genomic_DNA.
DR EMBL; CH471059; EAX07573.1; -; Genomic_DNA.
DR CCDS; CCDS351.2; -. [Q9GZU3-1]
DR RefSeq; NP_001306606.1; NM_001319677.1.
DR RefSeq; NP_001306607.1; NM_001319678.1. [Q9GZU3-4]
DR RefSeq; NP_001306608.1; NM_001319679.1. [Q9GZU3-4]
DR RefSeq; NP_060526.2; NM_018056.3. [Q9GZU3-1]
DR RefSeq; XP_011539986.1; XM_011541684.2. [Q9GZU3-4]
DR AlphaFoldDB; Q9GZU3; -.
DR BioGRID; 120425; 38.
DR IntAct; Q9GZU3; 13.
DR STRING; 9606.ENSP00000338165; -.
DR GlyGen; Q9GZU3; 1 site.
DR iPTMnet; Q9GZU3; -.
DR PhosphoSitePlus; Q9GZU3; -.
DR BioMuta; TMEM39B; -.
DR DMDM; 74752540; -.
DR EPD; Q9GZU3; -.
DR jPOST; Q9GZU3; -.
DR MassIVE; Q9GZU3; -.
DR MaxQB; Q9GZU3; -.
DR PaxDb; Q9GZU3; -.
DR PeptideAtlas; Q9GZU3; -.
DR PRIDE; Q9GZU3; -.
DR ProteomicsDB; 4475; -.
DR ProteomicsDB; 4863; -.
DR ProteomicsDB; 5118; -.
DR ProteomicsDB; 80148; -. [Q9GZU3-1]
DR Antibodypedia; 52402; 28 antibodies from 11 providers.
DR DNASU; 55116; -.
DR Ensembl; ENST00000336294.10; ENSP00000338165.5; ENSG00000121775.18. [Q9GZU3-1]
DR GeneID; 55116; -.
DR KEGG; hsa:55116; -.
DR MANE-Select; ENST00000336294.10; ENSP00000338165.5; NM_018056.4; NP_060526.2.
DR UCSC; uc010ogv.3; human. [Q9GZU3-1]
DR CTD; 55116; -.
DR GeneCards; TMEM39B; -.
DR HGNC; HGNC:25510; TMEM39B.
DR HPA; ENSG00000121775; Low tissue specificity.
DR neXtProt; NX_Q9GZU3; -.
DR OpenTargets; ENSG00000121775; -.
DR PharmGKB; PA134933688; -.
DR VEuPathDB; HostDB:ENSG00000121775; -.
DR eggNOG; KOG3828; Eukaryota.
DR GeneTree; ENSGT00390000018895; -.
DR HOGENOM; CLU_028992_2_0_1; -.
DR InParanoid; Q9GZU3; -.
DR OMA; IEWHFVL; -.
DR OrthoDB; 1154501at2759; -.
DR PhylomeDB; Q9GZU3; -.
DR TreeFam; TF321110; -.
DR PathwayCommons; Q9GZU3; -.
DR SignaLink; Q9GZU3; -.
DR BioGRID-ORCS; 55116; 21 hits in 1089 CRISPR screens.
DR ChiTaRS; TMEM39B; human.
DR GenomeRNAi; 55116; -.
DR Pharos; Q9GZU3; Tdark.
DR PRO; PR:Q9GZU3; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q9GZU3; protein.
DR Bgee; ENSG00000121775; Expressed in monocyte and 136 other tissues.
DR ExpressionAtlas; Q9GZU3; baseline and differential.
DR Genevisible; Q9GZU3; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR InterPro; IPR019397; Uncharacterised_TMEM39.
DR PANTHER; PTHR12995; PTHR12995; 1.
DR Pfam; PF10271; Tmp39; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Glycoprotein; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..492
FT /note="Transmembrane protein 39B"
FT /id="PRO_0000279232"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 115..135
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 153..175
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 185..205
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..308
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 322..342
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 421..441
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 447..467
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..54
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 8
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..199
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_056123"
FT VAR_SEQ 1..117
FT /note="MGGRRGPNRTSYCRNPLCEPGSSGGSSGSHTSSASVTSVRSRTRSSSGTGLS
FT SPPLATQTVVPLQHCKIPELPVQASILFELQLFFCQLIALFVHYINIYKTVWWYPPSHP
FT PSHTSL -> MK (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_056124"
FT VAR_SEQ 146..221
FT /note="ASQRGKVSLFRSILLFLTRFTVLTATGWSLCRSLIHLFRTYSFLNLLFLCYP
FT FGMYIPFLQLNCDLRKTSLFNHMA -> VWDVHSVPAAELRPPQDKPLQPHGLHGAPGG
FT GQWPGKEPGLPPDTAGDVEAAHKTAVWPGRHAHPCLLPVTQPHPQ (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_056125"
FT VAR_SEQ 222..492
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_056126"
FT VAR_SEQ 413..457
FT /note="FFFSKPLRILNILLLLEGAVIVYQLYSLMSSEKWHQTISLALILF -> VSL
FT LPGEGGLGPERVGGSAGQECDVIARESYFQYFPNPKEDSAHM (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_056127"
FT VAR_SEQ 458..492
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_056128"
FT CONFLICT 72
FT /note="L -> P (in Ref. 3; CAG33592)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 492 AA; 56274 MW; 7DB7A225AA8BC9A8 CRC64;
MGGRRGPNRT SYCRNPLCEP GSSGGSSGSH TSSASVTSVR SRTRSSSGTG LSSPPLATQT
VVPLQHCKIP ELPVQASILF ELQLFFCQLI ALFVHYINIY KTVWWYPPSH PPSHTSLNFH
LIDFNLLMVT TIVLGRRFIG SIVKEASQRG KVSLFRSILL FLTRFTVLTA TGWSLCRSLI
HLFRTYSFLN LLFLCYPFGM YIPFLQLNCD LRKTSLFNHM ASMGPREAVS GLAKSRDYLL
TLRETWKQHT RQLYGPDAMP THACCLSPSL IRSEVEFLKM DFNWRMKEVL VSSMLSAYYV
AFVPVWFVKN THYYDKRWSC ELFLLVSIST SVILMQHLLP ASYCDLLHKA AAHLGCWQKV
DPALCSNVLQ HPWTEECMWP QGVLVKHSKN VYKAVGHYNV AIPSDVSHFR FHFFFSKPLR
ILNILLLLEG AVIVYQLYSL MSSEKWHQTI SLALILFSNY YAFFKLLRDR LVLGKAYSYS
ASPQRDLDHR FS
