ID   TM39B_MOUSE             Reviewed;         492 AA.
AC   Q810L4;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Transmembrane protein 39B;
GN   Name=Tmem39b;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   PROTEIN SEQUENCE OF 227-236, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC   STRAIN=OF1; TISSUE=Hippocampus;
RA   Lubec G., Sunyer B., Chen W.-Q.;
RL   Submitted (JAN-2009) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TMEM39 family. {ECO:0000305}.
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DR   EMBL; AL671759; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC049790; AAH49790.1; -; mRNA.
DR   CCDS; CCDS18702.1; -.
DR   RefSeq; NP_955009.1; NM_199305.1.
DR   AlphaFoldDB; Q810L4; -.
DR   STRING; 10090.ENSMUSP00000099648; -.
DR   GlyGen; Q810L4; 1 site.
DR   iPTMnet; Q810L4; -.
DR   PhosphoSitePlus; Q810L4; -.
DR   EPD; Q810L4; -.
DR   MaxQB; Q810L4; -.
DR   PaxDb; Q810L4; -.
DR   PRIDE; Q810L4; -.
DR   ProteomicsDB; 259230; -.
DR   Antibodypedia; 52402; 28 antibodies from 11 providers.
DR   DNASU; 230770; -.
DR   Ensembl; ENSMUST00000102588; ENSMUSP00000099648; ENSMUSG00000053730.
DR   GeneID; 230770; -.
DR   KEGG; mmu:230770; -.
DR   UCSC; uc008uya.1; mouse.
DR   CTD; 55116; -.
DR   MGI; MGI:2682939; Tmem39b.
DR   VEuPathDB; HostDB:ENSMUSG00000053730; -.
DR   eggNOG; KOG3828; Eukaryota.
DR   GeneTree; ENSGT00390000018895; -.
DR   HOGENOM; CLU_028992_2_0_1; -.
DR   InParanoid; Q810L4; -.
DR   OMA; IEWHFVL; -.
DR   OrthoDB; 1460710at2759; -.
DR   PhylomeDB; Q810L4; -.
DR   TreeFam; TF321110; -.
DR   BioGRID-ORCS; 230770; 4 hits in 72 CRISPR screens.
DR   ChiTaRS; Tmem39b; mouse.
DR   PRO; PR:Q810L4; -.
DR   Proteomes; UP000000589; Chromosome 4.
DR   RNAct; Q810L4; protein.
DR   Bgee; ENSMUSG00000053730; Expressed in embryonic brain and 212 other tissues.
DR   ExpressionAtlas; Q810L4; baseline and differential.
DR   Genevisible; Q810L4; MM.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   InterPro; IPR019397; Uncharacterised_TMEM39.
DR   PANTHER; PTHR12995; PTHR12995; 1.
DR   Pfam; PF10271; Tmp39; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Glycoprotein; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..492
FT                   /note="Transmembrane protein 39B"
FT                   /id="PRO_0000279233"
FT   TRANSMEM        77..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        115..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        153..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        185..205
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        288..308
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        322..342
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        421..441
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        447..467
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..53
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        25..53
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        8
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   492 AA;  56377 MW;  2F894490074BC8B5 CRC64;
     MGGRRGPNRT SYYRNPLCEP GSSGASGGGH SSSASVSSVR SRSRTTSGTG LSSPPLAAQT
     VVPLQHCKIP ELPVQASILF ELQLFFCQLI ALFVHYINIY KTVWWYPPSH PPSHTSLNFH
     LIDFNLLMVT AIVLGRRFIG SIVKEASQRG KVSLFRSILL FLTRFTVLTA TGWSLCRSLI
     HLFRTYSFLN LLFLCYPFGM YIPFLQLNYD LRKTNLFTHM ASMGPREAVS GLARSRDYFL
     TLRETWKQHT RQLYGPEAMP THACCLSPSL IRNEVEFLKM DFNWRMKEVL VSSMLSAYYV
     AFVPVWFVKN THYYDKRWSC ELFLLVSIST SVILMQHLLP ASYCDLLHKA AAHLGCWQKV
     DPALCSNVLQ HPWTEECMWP QGVLVKHSKN VYKAVGHYNV AIPSDVSHFR FHFFFSNPLR
     ILNILLLLEG AVIVYQLYSL MSSEKWHQTI SLALILFSNY YAFFKLLRDR LVLGKAYSYS
     ASPQRDLDHR FS