ID   TM40L_BOVIN             Reviewed;         308 AA.
AC   A6QR22; Q58D64;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Mitochondrial import receptor subunit TOM40B;
DE   AltName: Full=Protein TOMM40-like;
GN   Name=TOMM40L {ECO:0000250|UniProtKB:Q969M1};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1] {ECO:0000312|EMBL:AAX46580.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2] {ECO:0000312|EMBL:AAI50082.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford {ECO:0000312|EMBL:AAI50082.1};
RC   TISSUE=Thalamus {ECO:0000312|EMBL:AAI50082.1};
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Potential channel-forming protein implicated in import of
CC       protein precursors into mitochondria. {ECO:0000250|UniProtKB:A4F267}.
CC   -!- SUBUNIT: Forms part of the preprotein translocase of the outer
CC       mitochondrial membrane (TOM complex) containing TOMM22, TOMM40, TOMM40L
CC       and TOMM70. Interacts with mitochondrial targeting sequences (By
CC       similarity). {ECO:0000250|UniProtKB:A4F267}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC       {ECO:0000250|UniProtKB:A4F267}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:A4F267}.
CC   -!- SIMILARITY: Belongs to the Tom40 family. {ECO:0000255}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAX46580.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; BT021733; AAX46580.1; ALT_FRAME; mRNA.
DR   EMBL; BC150081; AAI50082.1; -; mRNA.
DR   RefSeq; NP_001014853.1; NM_001014853.1.
DR   RefSeq; XP_005203529.1; XM_005203472.3.
DR   AlphaFoldDB; A6QR22; -.
DR   SMR; A6QR22; -.
DR   STRING; 9913.ENSBTAP00000012142; -.
DR   PaxDb; A6QR22; -.
DR   PRIDE; A6QR22; -.
DR   Ensembl; ENSBTAT00000054884; ENSBTAP00000052024; ENSBTAG00000009213.
DR   GeneID; 505393; -.
DR   KEGG; bta:505393; -.
DR   CTD; 84134; -.
DR   VEuPathDB; HostDB:ENSBTAG00000009213; -.
DR   VGNC; VGNC:49581; TOMM40L.
DR   eggNOG; KOG3296; Eukaryota.
DR   GeneTree; ENSGT00390000003308; -.
DR   HOGENOM; CLU_054399_0_0_1; -.
DR   InParanoid; A6QR22; -.
DR   OMA; MNLPCPV; -.
DR   OrthoDB; 1346842at2759; -.
DR   Proteomes; UP000009136; Chromosome 3.
DR   Bgee; ENSBTAG00000009213; Expressed in retina and 105 other tissues.
DR   ExpressionAtlas; A6QR22; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005742; C:mitochondrial outer membrane translocase complex; IBA:GO_Central.
DR   GO; GO:0008320; F:protein transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0030150; P:protein import into mitochondrial matrix; IBA:GO_Central.
DR   CDD; cd07305; Porin3_Tom40; 1.
DR   Gene3D; 2.40.160.10; -; 1.
DR   InterPro; IPR023614; Porin_dom_sf.
DR   InterPro; IPR027246; Porin_Euk/Tom40.
DR   InterPro; IPR037930; Tom40.
DR   PANTHER; PTHR10802; PTHR10802; 1.
DR   Pfam; PF01459; Porin_3; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion outer membrane; Protein transport;
KW   Reference proteome; Transmembrane; Transmembrane beta strand; Transport.
FT   CHAIN           1..308
FT                   /note="Mitochondrial import receptor subunit TOM40B"
FT                   /id="PRO_0000312686"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          281..308
FT                   /note="Required for mitochondrial targeting"
FT                   /evidence="ECO:0000250|UniProtKB:A4F267"
FT   COMPBIAS        15..29
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   308 AA;  33811 MW;  BF449D83CF3CBE30 CRC64;
     MGNTLGLAPM GALPRRSPRR EEPLPNPGSF DELHRLCKDV FPAQMEGVKL VVNKVLSSHF
     QVAHTVHMSA LGLPGYHLHA AYAGDWQLSP TEVFPTVVGD MDSGGSLNAQ VLLLLAERLR
     AKAVFQTQQA KFLTWQFDGE YRGDDYTATL TLGNPDLIGE SVIVVAHFLQ SLTHRLVLGG
     ELVYHRRPGE EGAILTLAGK YSAVHWVATL NVGSGGAHAS YYHRANEQVQ VGVEFEANTR
     LQDTTFSFGY HLTLPQANMV FRGLVDSNWC VGAVLEKKMP PLPVTLALGA FLNHWRNRFH
     CGFSITVG