TM40L_MOUSE
ID TM40L_MOUSE Reviewed; 308 AA.
AC Q9CZR3;
DT 07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Mitochondrial import receptor subunit TOM40B;
DE AltName: Full=Protein TOMM40-like;
GN Name=Tomm40l; Synonyms=Tomm40b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Placenta;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Heart;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Potential channel-forming protein implicated in import of
CC protein precursors into mitochondria. {ECO:0000250}.
CC -!- SUBUNIT: Forms part of the preprotein translocase of the outer
CC mitochondrial membrane (TOM complex) containing TOMM22, TOMM40, TOMM40L
CC and TOMM70. Interacts with mitochondrial targeting sequences (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the Tom40 family. {ECO:0000305}.
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DR EMBL; AK012264; BAB28127.1; -; mRNA.
DR EMBL; AK028388; BAC25924.1; -; mRNA.
DR EMBL; BC058978; AAH58978.1; -; mRNA.
DR CCDS; CCDS15481.1; -.
DR RefSeq; NP_001032247.1; NM_001037170.2.
DR RefSeq; XP_006497016.1; XM_006496953.3.
DR AlphaFoldDB; Q9CZR3; -.
DR SMR; Q9CZR3; -.
DR STRING; 10090.ENSMUSP00000005817; -.
DR iPTMnet; Q9CZR3; -.
DR PhosphoSitePlus; Q9CZR3; -.
DR SwissPalm; Q9CZR3; -.
DR EPD; Q9CZR3; -.
DR MaxQB; Q9CZR3; -.
DR PaxDb; Q9CZR3; -.
DR PRIDE; Q9CZR3; -.
DR ProteomicsDB; 260700; -.
DR Antibodypedia; 34305; 100 antibodies from 18 providers.
DR Ensembl; ENSMUST00000005817; ENSMUSP00000005817; ENSMUSG00000005674.
DR Ensembl; ENSMUST00000111327; ENSMUSP00000106959; ENSMUSG00000005674.
DR GeneID; 641376; -.
DR KEGG; mmu:641376; -.
DR UCSC; uc007dni.1; mouse.
DR CTD; 84134; -.
DR MGI; MGI:3589112; Tomm40l.
DR VEuPathDB; HostDB:ENSMUSG00000005674; -.
DR eggNOG; KOG3296; Eukaryota.
DR GeneTree; ENSGT00390000003308; -.
DR InParanoid; Q9CZR3; -.
DR OMA; MNLPCPV; -.
DR OrthoDB; 1346842at2759; -.
DR PhylomeDB; Q9CZR3; -.
DR TreeFam; TF106204; -.
DR BioGRID-ORCS; 641376; 5 hits in 72 CRISPR screens.
DR ChiTaRS; Tomm40l; mouse.
DR PRO; PR:Q9CZR3; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q9CZR3; protein.
DR Bgee; ENSMUSG00000005674; Expressed in interventricular septum and 246 other tissues.
DR ExpressionAtlas; Q9CZR3; baseline and differential.
DR Genevisible; Q9CZR3; MM.
DR GO; GO:0005742; C:mitochondrial outer membrane translocase complex; ISO:MGI.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR GO; GO:0032991; C:protein-containing complex; ISO:MGI.
DR GO; GO:0030943; F:mitochondrion targeting sequence binding; ISO:MGI.
DR GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR GO; GO:0070678; F:preprotein binding; ISO:MGI.
DR GO; GO:0008320; F:protein transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR GO; GO:0030150; P:protein import into mitochondrial matrix; IBA:GO_Central.
DR CDD; cd07305; Porin3_Tom40; 1.
DR Gene3D; 2.40.160.10; -; 1.
DR InterPro; IPR023614; Porin_dom_sf.
DR InterPro; IPR027246; Porin_Euk/Tom40.
DR InterPro; IPR037930; Tom40.
DR PANTHER; PTHR10802; PTHR10802; 1.
DR Pfam; PF01459; Porin_3; 1.
PE 1: Evidence at protein level;
KW Ion transport; Membrane; Mitochondrion; Mitochondrion outer membrane;
KW Porin; Protein transport; Reference proteome; Transmembrane;
KW Transmembrane beta strand; Transport.
FT CHAIN 1..308
FT /note="Mitochondrial import receptor subunit TOM40B"
FT /id="PRO_0000051537"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 281..308
FT /note="Required for mitochondrial targeting"
FT /evidence="ECO:0000250"
FT COMPBIAS 14..29
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 308 AA; 34005 MW; 413D66AED372D967 CRC64;
MGNTLGLAPM GTLPRRSHRR EEPLPNPGSF DELHRLCKDV FPAQMEGVKL VVNKVLSSHF
QVAHTVHMSA LGLPGYHLHT AYAGDWQLSP TEVFPTVVGD MDSSGSLNAQ VLLLLAERLR
AKAVFQTQQA KFLTWQFDGE YRGDDYTATL TLGNPDLIGE SVIMVAHFLQ SITHRLVLGG
ELVYHRRPGE EGAILTLAGK YSAVHWVATL NVGSGGAHAS YYHKANEQVQ VGVEFEANTR
LQDTTFSFGY HLTLPQADMV FRGLVDSNWC VGAVLEKKMR PLPVTLALGA FLNHWRNRFH
CGFSITVG
