ID   TM40L_RAT               Reviewed;         308 AA.
AC   A4F267;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   17-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Mitochondrial import receptor subunit TOM40B;
DE   AltName: Full=Protein TOMM40-like;
GN   Name=Tomm40l {ECO:0000250|UniProtKB:Q969M1};
GN   Synonyms=Tomm40b {ECO:0000312|EMBL:BAF49085.1};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:BAF49085.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, IDENTIFICATION IN THE TOM COMPLEX
RP   WITH TOMM40; TOMM22 AND TOMM70, SUBCELLULAR LOCATION, TISSUE SPECIFICITY,
RP   AND INTERACTION WITH MITOCHONDRIAL TARGETING SEQUENCES.
RX   PubMed=17437969; DOI=10.1093/jb/mvm097;
RA   Kinoshita J.Y., Mihara K., Oka T.;
RT   "Identification and characterization of a new Tom40 isoform, a central
RT   component of mitochondrial outer membrane translocase.";
RL   J. Biochem. 141:897-906(2007).
CC   -!- FUNCTION: Potential channel-forming protein implicated in import of
CC       protein precursors into mitochondria. {ECO:0000269|PubMed:17437969}.
CC   -!- SUBUNIT: Forms part of the preprotein translocase of the outer
CC       mitochondrial membrane (TOM complex) containing TOMM22, TOMM40, TOMM40L
CC       and TOMM70. Interacts with mitochondrial targeting sequences.
CC       {ECO:0000269|PubMed:17437969}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC       {ECO:0000269|PubMed:17437969}; Multi-pass membrane protein
CC       {ECO:0000269|PubMed:17437969}.
CC   -!- TISSUE SPECIFICITY: Widely expressed. Higher levels in heart, brain and
CC       liver, very low level in testis. {ECO:0000269|PubMed:17437969}.
CC   -!- SIMILARITY: Belongs to the Tom40 family. {ECO:0000255}.
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DR   EMBL; AB274732; BAF49085.1; -; mRNA.
DR   RefSeq; NP_001076807.1; NM_001083338.1.
DR   RefSeq; XP_006250309.1; XM_006250247.3.
DR   AlphaFoldDB; A4F267; -.
DR   SMR; A4F267; -.
DR   BioGRID; 258038; 1.
DR   STRING; 10116.ENSRNOP00000004641; -.
DR   PaxDb; A4F267; -.
DR   PeptideAtlas; A4F267; -.
DR   Ensembl; ENSRNOT00000004641; ENSRNOP00000004641; ENSRNOG00000003398.
DR   GeneID; 304971; -.
DR   KEGG; rno:304971; -.
DR   UCSC; RGD:1562006; rat.
DR   CTD; 84134; -.
DR   RGD; 1562006; Tomm40l.
DR   eggNOG; KOG3296; Eukaryota.
DR   GeneTree; ENSGT00390000003308; -.
DR   HOGENOM; CLU_054399_0_0_1; -.
DR   InParanoid; A4F267; -.
DR   OMA; MNLPCPV; -.
DR   OrthoDB; 1346842at2759; -.
DR   PhylomeDB; A4F267; -.
DR   TreeFam; TF106204; -.
DR   PRO; PR:A4F267; -.
DR   Proteomes; UP000002494; Chromosome 13.
DR   Bgee; ENSRNOG00000003398; Expressed in heart and 19 other tissues.
DR   Genevisible; A4F267; RN.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005742; C:mitochondrial outer membrane translocase complex; IDA:RGD.
DR   GO; GO:0030943; F:mitochondrion targeting sequence binding; IDA:RGD.
DR   GO; GO:0070678; F:preprotein binding; IDA:RGD.
DR   GO; GO:0008320; F:protein transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0030150; P:protein import into mitochondrial matrix; IBA:GO_Central.
DR   CDD; cd07305; Porin3_Tom40; 1.
DR   Gene3D; 2.40.160.10; -; 1.
DR   InterPro; IPR023614; Porin_dom_sf.
DR   InterPro; IPR027246; Porin_Euk/Tom40.
DR   InterPro; IPR037930; Tom40.
DR   PANTHER; PTHR10802; PTHR10802; 1.
DR   Pfam; PF01459; Porin_3; 1.
PE   1: Evidence at protein level;
KW   Membrane; Mitochondrion; Mitochondrion outer membrane; Protein transport;
KW   Reference proteome; Transmembrane; Transmembrane beta strand; Transport.
FT   CHAIN           1..308
FT                   /note="Mitochondrial import receptor subunit TOM40B"
FT                   /id="PRO_0000312687"
FT   REGION          281..308
FT                   /note="Required for mitochondrial targeting"
FT                   /evidence="ECO:0000269|PubMed:17437969"
SQ   SEQUENCE   308 AA;  34049 MW;  ABD54E0E91673E18 CRC64;
     MGNTLGLAPM GTLPRWSHRR EEPLPNPGSF DELHRLCKDV FPAQMEGVKL VVNKVLSSHF
     QVAHTVHMSA LGLPGYHLHT AYAGDWQLSP TEVFPTVVGD MDSSGSLNAQ VLLLLAERLR
     AKAVFQTQQA KFLTWQFDGE YRGDDYTATL TLGNPDLIGE SVIMVAHFLQ SITHRLVLGG
     ELVYHRRPGE EGAILTLAGK YSALHWVATL NVGSGGAHAS YYHKANEQVQ VGVEFEANTR
     LQDTTFSFGY HLTLPQADMV FRGLVDSNWC VGAVLEKKMR PLPVTLALGA FLNHWRNRFH
     CGFSITVG