ID   TM41A_BOVIN             Reviewed;         264 AA.
AC   Q08D99;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Transmembrane protein 41A;
DE   Flags: Precursor;
GN   Name=TMEM41A;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Basal ganglia;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- DOMAIN: The VTT domain was previously called the SNARE-assoc domain. As
CC       there is no evidence that this domain associates with SNARE proteins,
CC       it was renamed as VMP1, TMEM41, and TVP38 (VTT) domain.
CC       {ECO:0000250|UniProtKB:Q96HV5}.
CC   -!- SIMILARITY: Belongs to the TMEM41 family. {ECO:0000305}.
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DR   EMBL; BC123868; AAI23869.1; -; mRNA.
DR   RefSeq; NP_001068668.1; NM_001075200.1.
DR   AlphaFoldDB; Q08D99; -.
DR   STRING; 9913.ENSBTAP00000022752; -.
DR   PaxDb; Q08D99; -.
DR   PRIDE; Q08D99; -.
DR   Ensembl; ENSBTAT00000022752; ENSBTAP00000022752; ENSBTAG00000017115.
DR   GeneID; 505368; -.
DR   KEGG; bta:505368; -.
DR   CTD; 90407; -.
DR   VEuPathDB; HostDB:ENSBTAG00000017115; -.
DR   VGNC; VGNC:36085; TMEM41A.
DR   eggNOG; KOG3140; Eukaryota.
DR   GeneTree; ENSGT00940000163412; -.
DR   HOGENOM; CLU_038944_0_2_1; -.
DR   InParanoid; Q08D99; -.
DR   OMA; DNRDCLF; -.
DR   OrthoDB; 1222755at2759; -.
DR   TreeFam; TF314301; -.
DR   Proteomes; UP000009136; Chromosome 1.
DR   Bgee; ENSBTAG00000017115; Expressed in prostate gland and 107 other tissues.
DR   ExpressionAtlas; Q08D99; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR032816; SNARE_assoc.
DR   InterPro; IPR045014; TM41A/B.
DR   PANTHER; PTHR43220; PTHR43220; 1.
DR   Pfam; PF09335; SNARE_assoc; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..264
FT                   /note="Transmembrane protein 41A"
FT                   /id="PRO_0000271774"
FT   TRANSMEM        67..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        90..110
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        153..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        175..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        219..239
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          96..207
FT                   /note="VTT domain"
FT                   /evidence="ECO:0000250|UniProtKB:Q96HV5"
SQ   SEQUENCE   264 AA;  29577 MW;  8162BF990B704F5A CRC64;
     MHSLLGLLLV FAGSTFALYL LSTRLPRAST LVSAEESGDR SLWFPSDLAE LRELSEVLRE
     YRKEHQVYVF LLFCSAYLYK QSFAIPGSSF LNVLAGALFG PWLGLLLCCV LTSVGATGCY
     LLSSVFGKQL VVFYFPDKVA LLQKKVEENR NGLFFFLLFL RLFPMTPNWF LNLSAPILNI
     PIVQFFFSVL IGLIPYNFIC VQTGSILSTL TSLDALFSWE TAFKLLAIAL VALVPGTLIK
     KFSQKDLRLK ETSNTHSLNS RKVT