TM41A_HUMAN
ID TM41A_HUMAN Reviewed; 264 AA.
AC Q96HV5; A8K4B3; D3DNU2; Q6ZMJ0;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Transmembrane protein 41A;
DE Flags: Precursor;
GN Name=TMEM41A; ORFNames=UNQ168/PRO194;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Adipose tissue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP REGION VTT DOMAIN.
RX PubMed=30093494; DOI=10.1083/jcb.201804132;
RA Morita K., Hama Y., Izume T., Tamura N., Ueno T., Yamashita Y.,
RA Sakamaki Y., Mimura K., Morishita H., Shihoya W., Nureki O., Mano H.,
RA Mizushima N.;
RT "Genome-wide CRISPR screen identifies TMEM41B as a gene required for
RT autophagosome formation.";
RL J. Cell Biol. 217:3817-3828(2018).
CC -!- INTERACTION:
CC Q96HV5; O43169: CYB5B; NbExp=3; IntAct=EBI-10288884, EBI-1058710;
CC Q96HV5; Q7L5A8: FA2H; NbExp=3; IntAct=EBI-10288884, EBI-11337888;
CC Q96HV5; Q8N6L0: KASH5; NbExp=3; IntAct=EBI-10288884, EBI-749265;
CC Q96HV5; Q9UBY5: LPAR3; NbExp=3; IntAct=EBI-10288884, EBI-12033434;
CC Q96HV5; Q7Z3S9: NOTCH2NLA; NbExp=3; IntAct=EBI-10288884, EBI-945833;
CC Q96HV5; P18031: PTPN1; NbExp=3; IntAct=EBI-10288884, EBI-968788;
CC Q96HV5; Q16623: STX1A; NbExp=3; IntAct=EBI-10288884, EBI-712466;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- DOMAIN: The VTT domain was previously called the SNARE-assoc domain. As
CC there is no evidence that this domain associates with SNARE proteins,
CC it was renamed as VMP1, TMEM41, and TVP38 (VTT) domain.
CC {ECO:0000305|PubMed:30093494}.
CC -!- SIMILARITY: Belongs to the TMEM41 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAD18735.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO:0000305};
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DR EMBL; AY358547; AAQ88911.1; -; mRNA.
DR EMBL; AK172748; BAD18735.1; ALT_SEQ; mRNA.
DR EMBL; AK290878; BAF83567.1; -; mRNA.
DR EMBL; CH471052; EAW78219.1; -; Genomic_DNA.
DR EMBL; CH471052; EAW78223.1; -; Genomic_DNA.
DR EMBL; BC008043; AAH08043.1; -; mRNA.
DR EMBL; BC019884; AAH19884.1; -; mRNA.
DR CCDS; CCDS3271.1; -.
DR RefSeq; NP_542383.1; NM_080652.3.
DR AlphaFoldDB; Q96HV5; -.
DR BioGRID; 124709; 24.
DR IntAct; Q96HV5; 12.
DR STRING; 9606.ENSP00000406885; -.
DR TCDB; 9.B.27.1.9; the death effector domain a (deda) family.
DR GlyGen; Q96HV5; 1 site.
DR iPTMnet; Q96HV5; -.
DR PhosphoSitePlus; Q96HV5; -.
DR SwissPalm; Q96HV5; -.
DR BioMuta; TMEM41A; -.
DR DMDM; 74731986; -.
DR EPD; Q96HV5; -.
DR jPOST; Q96HV5; -.
DR MassIVE; Q96HV5; -.
DR MaxQB; Q96HV5; -.
DR PaxDb; Q96HV5; -.
DR PeptideAtlas; Q96HV5; -.
DR PRIDE; Q96HV5; -.
DR ProteomicsDB; 76788; -.
DR Antibodypedia; 46836; 70 antibodies from 15 providers.
DR DNASU; 90407; -.
DR Ensembl; ENST00000421852.6; ENSP00000406885.1; ENSG00000163900.11.
DR GeneID; 90407; -.
DR KEGG; hsa:90407; -.
DR MANE-Select; ENST00000421852.6; ENSP00000406885.1; NM_080652.4; NP_542383.1.
DR UCSC; uc003fpj.2; human.
DR CTD; 90407; -.
DR DisGeNET; 90407; -.
DR GeneCards; TMEM41A; -.
DR HGNC; HGNC:30544; TMEM41A.
DR HPA; ENSG00000163900; Low tissue specificity.
DR neXtProt; NX_Q96HV5; -.
DR OpenTargets; ENSG00000163900; -.
DR PharmGKB; PA134873545; -.
DR VEuPathDB; HostDB:ENSG00000163900; -.
DR eggNOG; KOG3140; Eukaryota.
DR GeneTree; ENSGT00940000162528; -.
DR HOGENOM; CLU_038944_0_2_1; -.
DR InParanoid; Q96HV5; -.
DR OMA; DNRDCLF; -.
DR OrthoDB; 1222755at2759; -.
DR PhylomeDB; Q96HV5; -.
DR TreeFam; TF314301; -.
DR PathwayCommons; Q96HV5; -.
DR SignaLink; Q96HV5; -.
DR BioGRID-ORCS; 90407; 41 hits in 1082 CRISPR screens.
DR ChiTaRS; TMEM41A; human.
DR GenomeRNAi; 90407; -.
DR Pharos; Q96HV5; Tdark.
DR PRO; PR:Q96HV5; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q96HV5; protein.
DR Bgee; ENSG00000163900; Expressed in oocyte and 179 other tissues.
DR ExpressionAtlas; Q96HV5; baseline and differential.
DR Genevisible; Q96HV5; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR032816; SNARE_assoc.
DR InterPro; IPR045014; TM41A/B.
DR PANTHER; PTHR43220; PTHR43220; 1.
DR Pfam; PF09335; SNARE_assoc; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..264
FT /note="Transmembrane protein 41A"
FT /id="PRO_0000271775"
FT TRANSMEM 67..87
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..122
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 153..173
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 175..195
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 219..239
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 96..207
FT /note="VTT domain"
FT /evidence="ECO:0000305|PubMed:30093494"
FT CARBOHYD 250
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 264 AA; 29665 MW; 43525C886615C424 CRC64;
MRPLLGLLLV FAGCTFALYL LSTRLPRGRR LGSTEEAGGR SLWFPSDLAE LRELSEVLRE
YRKEHQAYVF LLFCGAYLYK QGFAIPGSSF LNVLAGALFG PWLGLLLCCV LTSVGATCCY
LLSSIFGKQL VVSYFPDKVA LLQRKVEENR NSLFFFLLFL RLFPMTPNWF LNLSAPILNI
PIVQFFFSVL IGLIPYNFIC VQTGSILSTL TSLDALFSWD TVFKLLAIAM VALIPGTLIK
KFSQKHLQLN ETSTANHIHS RKDT
