TM41A_MOUSE
ID TM41A_MOUSE Reviewed; 264 AA.
AC Q9D8U2;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Transmembrane protein 41A;
DE Flags: Precursor;
GN Name=Tmem41a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Pancreas;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- DOMAIN: The VTT domain was previously called the SNARE-assoc domain. As
CC there is no evidence that this domain associates with SNARE proteins,
CC it was renamed as VMP1, TMEM41, and TVP38 (VTT) domain.
CC {ECO:0000250|UniProtKB:Q96HV5}.
CC -!- SIMILARITY: Belongs to the TMEM41 family. {ECO:0000305}.
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DR EMBL; AK007685; BAB25189.1; -; mRNA.
DR EMBL; BC019770; AAH19770.1; -; mRNA.
DR CCDS; CCDS28064.1; -.
DR RefSeq; NP_079969.1; NM_025693.4.
DR AlphaFoldDB; Q9D8U2; -.
DR STRING; 10090.ENSMUSP00000023562; -.
DR PhosphoSitePlus; Q9D8U2; -.
DR EPD; Q9D8U2; -.
DR MaxQB; Q9D8U2; -.
DR PaxDb; Q9D8U2; -.
DR PeptideAtlas; Q9D8U2; -.
DR PRIDE; Q9D8U2; -.
DR ProteomicsDB; 262829; -.
DR DNASU; 66664; -.
DR Ensembl; ENSMUST00000023562; ENSMUSP00000023562; ENSMUSG00000022856.
DR GeneID; 66664; -.
DR KEGG; mmu:66664; -.
DR UCSC; uc007yrs.2; mouse.
DR CTD; 90407; -.
DR MGI; MGI:1913914; Tmem41a.
DR VEuPathDB; HostDB:ENSMUSG00000022856; -.
DR eggNOG; KOG3140; Eukaryota.
DR GeneTree; ENSGT00940000163412; -.
DR HOGENOM; CLU_038944_0_2_1; -.
DR InParanoid; Q9D8U2; -.
DR OMA; ERQHRGA; -.
DR OrthoDB; 1222755at2759; -.
DR PhylomeDB; Q9D8U2; -.
DR TreeFam; TF314301; -.
DR BioGRID-ORCS; 66664; 1 hit in 72 CRISPR screens.
DR PRO; PR:Q9D8U2; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q9D8U2; protein.
DR Bgee; ENSMUSG00000022856; Expressed in small intestine Peyer's patch and 252 other tissues.
DR ExpressionAtlas; Q9D8U2; baseline and differential.
DR Genevisible; Q9D8U2; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR032816; SNARE_assoc.
DR InterPro; IPR045014; TM41A/B.
DR PANTHER; PTHR43220; PTHR43220; 1.
DR Pfam; PF09335; SNARE_assoc; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..264
FT /note="Transmembrane protein 41A"
FT /id="PRO_0000271776"
FT TRANSMEM 67..87
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..122
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 153..173
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 175..195
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 219..239
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 96..207
FT /note="VTT domain"
FT /evidence="ECO:0000250|UniProtKB:Q96HV5"
SQ SEQUENCE 264 AA; 29370 MW; 2E8AC991F2944F2C CRC64;
MRALLGLLLV FGGCTFALYL LSTRLPLGPR LAAAGEPEGR SLWFPSDLAE LRELSEVLRE
YRKEHQAYVF LLFCSAYLYK QGFAIPGSSF LNVLAGALFG PWLGLLLCCV LTSVGATGCY
LLSSLFGKQL VISYFPDKVA LLQKKVEENR NSLFFFLLFL RLFPMTPNWF LNLSAPILNI
PIVQFFFSVL IGLIPYNFIC VQTGSILSTL TSLDALFSWE TVLKLLAIAL VALVPGTLIK
KFSQKRLALS ETSDIGHPDR RKDA
