BT2A1_HUMAN
ID BT2A1_HUMAN Reviewed; 527 AA.
AC Q7KYR7; B4DLP9; E9PGR4; O00475; P78408; Q59EN4; Q7KYQ7; Q7Z386; Q96AV7;
AC Q9NU62;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 3.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Butyrophilin subfamily 2 member A1;
DE Flags: Precursor;
GN Name=BTN2A1; Synonyms=BT2.1, BTF1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 2).
RX PubMed=9382921; DOI=10.1007/s002510050326;
RA Tazi-Ahnini R., Henry J., Offer C., Bouissou-Bouchouata C., Mather I.H.,
RA Pontarotti P.;
RT "Cloning, localization, and structure of new members of the butyrophilin
RT gene family in the juxta-telomeric region of the major histocompatibility
RT complex.";
RL Immunogenetics 47:55-63(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RX PubMed=9149941; DOI=10.1101/gr.7.5.441;
RA Ruddy D.A., Kronmal G.S., Lee V.K., Mintier G.A., Quintana L.,
RA Domingo R. Jr., Meyer N.C., Irrinki A., McClelland E.E., Fullan A.,
RA Mapa F.A., Moore T., Thomas W., Loeb D.B., Harmon C., Tsuchihashi Z.,
RA Wolff R.K., Schatzman R.C., Feder J.N.;
RT "A 1.1-Mb transcript map of the hereditary hemochromatosis locus.";
RL Genome Res. 7:441-456(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Colon endothelium;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6).
RC TISSUE=Brain;
RA Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.,
RA Ohara O., Nagase T., Kikuno R.F.;
RT "Homo sapiens protein coding cDNA.";
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
RC TISSUE=Lymph;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-114 AND ASN-120.
RC TISSUE=Leukemic T-cell;
RX PubMed=19349973; DOI=10.1038/nbt.1532;
RA Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,
RA Schiess R., Aebersold R., Watts J.D.;
RT "Mass-spectrometric identification and relative quantification of N-linked
RT cell surface glycoproteins.";
RL Nat. Biotechnol. 27:378-386(2009).
CC -!- INTERACTION:
CC Q7KYR7-4; Q8N6F1-2: CLDN19; NbExp=3; IntAct=EBI-17841208, EBI-12256978;
CC Q7KYR7-4; Q4LDR2: CTXN3; NbExp=3; IntAct=EBI-17841208, EBI-12019274;
CC Q7KYR7-4; P21145: MAL; NbExp=3; IntAct=EBI-17841208, EBI-3932027;
CC Q7KYR7-4; P42857: NSG1; NbExp=3; IntAct=EBI-17841208, EBI-6380741;
CC Q7KYR7-4; Q8IY26: PLPP6; NbExp=3; IntAct=EBI-17841208, EBI-11721828;
CC Q7KYR7-4; P0DN84: STRIT1; NbExp=3; IntAct=EBI-17841208, EBI-12200293;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=6;
CC Name=1;
CC IsoId=Q7KYR7-2; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7KYR7-1; Sequence=VSP_035843, VSP_035844;
CC Name=3;
CC IsoId=Q7KYR7-3; Sequence=VSP_012708;
CC Name=4;
CC IsoId=Q7KYR7-4; Sequence=VSP_043165, VSP_043166;
CC Name=5;
CC IsoId=Q7KYR7-5; Sequence=VSP_044249;
CC Name=6;
CC IsoId=Q7KYR7-6; Sequence=VSP_045005, VSP_045006;
CC -!- TISSUE SPECIFICITY: Highly expressed in brain, bone marrow, small
CC intestine, muscle, spleen and pancreas. Moderate expression was seen in
CC lung, liver and kidney. {ECO:0000269|PubMed:9149941}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. BTN/MOG family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAD93014.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U90142; AAC02650.1; -; mRNA.
DR EMBL; U97496; AAC02653.1; -; Genomic_DNA.
DR EMBL; U97495; AAC02653.1; JOINED; Genomic_DNA.
DR EMBL; U97497; AAC02654.1; -; Genomic_DNA.
DR EMBL; U90543; AAB53421.1; -; mRNA.
DR EMBL; BX538050; CAD97989.1; -; mRNA.
DR EMBL; AK297098; BAG59611.1; -; mRNA.
DR EMBL; AB209777; BAD93014.1; ALT_INIT; mRNA.
DR EMBL; AL050330; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL121936; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC016661; AAH16661.1; -; mRNA.
DR CCDS; CCDS4613.1; -. [Q7KYR7-2]
DR CCDS; CCDS47390.1; -. [Q7KYR7-4]
DR CCDS; CCDS56404.1; -. [Q7KYR7-6]
DR CCDS; CCDS56405.1; -. [Q7KYR7-5]
DR RefSeq; NP_001184162.1; NM_001197233.2. [Q7KYR7-5]
DR RefSeq; NP_001184163.1; NM_001197234.2. [Q7KYR7-6]
DR RefSeq; NP_008980.1; NM_007049.4. [Q7KYR7-2]
DR RefSeq; NP_510961.1; NM_078476.3. [Q7KYR7-4]
DR AlphaFoldDB; Q7KYR7; -.
DR SMR; Q7KYR7; -.
DR BioGRID; 116295; 63.
DR IntAct; Q7KYR7; 31.
DR STRING; 9606.ENSP00000312158; -.
DR GlyGen; Q7KYR7; 3 sites.
DR iPTMnet; Q7KYR7; -.
DR PhosphoSitePlus; Q7KYR7; -.
DR BioMuta; BTN2A1; -.
DR DMDM; 215274180; -.
DR EPD; Q7KYR7; -.
DR jPOST; Q7KYR7; -.
DR MassIVE; Q7KYR7; -.
DR MaxQB; Q7KYR7; -.
DR PaxDb; Q7KYR7; -.
DR PeptideAtlas; Q7KYR7; -.
DR PRIDE; Q7KYR7; -.
DR ProteomicsDB; 20375; -.
DR ProteomicsDB; 4549; -.
DR ProteomicsDB; 68699; -. [Q7KYR7-2]
DR ProteomicsDB; 68700; -. [Q7KYR7-1]
DR ProteomicsDB; 68701; -. [Q7KYR7-3]
DR ProteomicsDB; 68702; -. [Q7KYR7-4]
DR Antibodypedia; 11060; 254 antibodies from 27 providers.
DR DNASU; 11120; -.
DR Ensembl; ENST00000312541.10; ENSP00000312158.5; ENSG00000112763.17. [Q7KYR7-2]
DR Ensembl; ENST00000429381.5; ENSP00000416945.1; ENSG00000112763.17. [Q7KYR7-4]
DR Ensembl; ENST00000469185.5; ENSP00000419043.1; ENSG00000112763.17. [Q7KYR7-6]
DR Ensembl; ENST00000541522.5; ENSP00000443909.1; ENSG00000112763.17. [Q7KYR7-5]
DR GeneID; 11120; -.
DR KEGG; hsa:11120; -.
DR MANE-Select; ENST00000312541.10; ENSP00000312158.5; NM_007049.5; NP_008980.1.
DR UCSC; uc003nib.4; human. [Q7KYR7-2]
DR CTD; 11120; -.
DR DisGeNET; 11120; -.
DR GeneCards; BTN2A1; -.
DR HGNC; HGNC:1136; BTN2A1.
DR HPA; ENSG00000112763; Low tissue specificity.
DR MIM; 613590; gene.
DR neXtProt; NX_Q7KYR7; -.
DR OpenTargets; ENSG00000112763; -.
DR PharmGKB; PA25456; -.
DR VEuPathDB; HostDB:ENSG00000112763; -.
DR eggNOG; ENOG502QSRZ; Eukaryota.
DR GeneTree; ENSGT00940000163835; -.
DR HOGENOM; CLU_013137_22_2_1; -.
DR InParanoid; Q7KYR7; -.
DR OMA; AETHHNH; -.
DR OrthoDB; 522383at2759; -.
DR PhylomeDB; Q7KYR7; -.
DR TreeFam; TF331083; -.
DR PathwayCommons; Q7KYR7; -.
DR Reactome; R-HSA-8851680; Butyrophilin (BTN) family interactions.
DR SignaLink; Q7KYR7; -.
DR BioGRID-ORCS; 11120; 8 hits in 1076 CRISPR screens.
DR ChiTaRS; BTN2A1; human.
DR GenomeRNAi; 11120; -.
DR Pharos; Q7KYR7; Tbio.
DR PRO; PR:Q7KYR7; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q7KYR7; protein.
DR Bgee; ENSG00000112763; Expressed in granulocyte and 201 other tissues.
DR ExpressionAtlas; Q7KYR7; baseline and differential.
DR Genevisible; Q7KYR7; HS.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR GO; GO:0006629; P:lipid metabolic process; TAS:ProtInc.
DR GO; GO:0001817; P:regulation of cytokine production; IBA:GO_Central.
DR GO; GO:0050852; P:T cell receptor signaling pathway; IBA:GO_Central.
DR CDD; cd15819; SPRY_PRY_BTN1_2; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR037958; SPRY/PRY_BTN1/2.
DR InterPro; IPR003877; SPRY_dom.
DR Pfam; PF13765; PRY; 1.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF07686; V-set; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00409; IG; 1.
DR SMART; SM00406; IGv; 1.
DR SMART; SM00589; PRY; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF48726; SSF48726; 2.
DR SUPFAM; SSF49899; SSF49899; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Disulfide bond; Glycoprotein;
KW Immunoglobulin domain; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..28
FT /evidence="ECO:0000255"
FT CHAIN 29..527
FT /note="Butyrophilin subfamily 2 member A1"
FT /id="PRO_0000014529"
FT TOPO_DOM 29..248
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 249..269
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 270..527
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 29..141
FT /note="Ig-like V-type"
FT DOMAIN 310..506
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
FT CARBOHYD 46
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 114
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:19349973"
FT CARBOHYD 120
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:19349973"
FT DISULFID 51..125
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VAR_SEQ 1..152
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_012708"
FT VAR_SEQ 1..61
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_044249"
FT VAR_SEQ 247..262
FT /note="CAVALPIIVVILMIPI -> L (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:9382921"
FT /id="VSP_035843"
FT VAR_SEQ 328..334
FT /note="VDVVLDP -> ELQFFSN (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_043165"
FT VAR_SEQ 328..330
FT /note="VDV -> GPV (in isoform 6)"
FT /evidence="ECO:0000303|Ref.5"
FT /id="VSP_045005"
FT VAR_SEQ 331..527
FT /note="Missing (in isoform 6)"
FT /evidence="ECO:0000303|Ref.5"
FT /id="VSP_045006"
FT VAR_SEQ 335..527
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_043166"
FT VAR_SEQ 482..527
FT /note="VPVRPFFRLGCEDSPIFICPALTGANGVTVPEEGLTLHRVGTHQSL -> GP
FT DTSQSGDPPEPIESIPWSHSHVDKPWSFQQPPHNTHLPAASFTPTTDLSPSFLLLTRLC
FT F (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:9382921"
FT /id="VSP_035844"
FT VARIANT 124
FT /note="R -> C (in dbSNP:rs3734539)"
FT /id="VAR_049825"
FT VARIANT 178
FT /note="W -> C (in dbSNP:rs13195402)"
FT /id="VAR_061303"
FT VARIANT 178
FT /note="W -> L (in dbSNP:rs13195401)"
FT /id="VAR_061304"
FT VARIANT 207
FT /note="V -> M (in dbSNP:rs13195509)"
FT /id="VAR_049826"
FT VARIANT 378
FT /note="R -> Q (in dbSNP:rs3734542)"
FT /id="VAR_049827"
FT VARIANT 451
FT /note="G -> A (in dbSNP:rs3734543)"
FT /id="VAR_049828"
FT CONFLICT 29
FT /note="Q -> H (in Ref. 1; AAC02650/AAC02653)"
FT /evidence="ECO:0000305"
FT CONFLICT 119
FT /note="E -> G (in Ref. 1; AAC02650/AAC02653)"
FT /evidence="ECO:0000305"
FT CONFLICT 144
FT /note="G -> ER (in Ref. 1; AAC02650/AAC02653)"
FT /evidence="ECO:0000305"
FT CONFLICT 208
FT /note="I -> V (in Ref. 3; CAD97989)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 527 AA; 59633 MW; 0EB0731062E02F6C CRC64;
MESAAALHFS RPASLLLLLL SLCALVSAQF IVVGPTDPIL ATVGENTTLR CHLSPEKNAE
DMEVRWFRSQ FSPAVFVYKG GRERTEEQME EYRGRTTFVS KDISRGSVAL VIHNITAQEN
GTYRCYFQEG RSYDEAILHL VVAGLGSKPL ISMRGHEDGG IRLECISRGW YPKPLTVWRD
PYGGVAPALK EVSMPDADGL FMVTTAVIIR DKSVRNMSCS INNTLLGQKK ESVIFIPESF
MPSVSPCAVA LPIIVVILMI PIAVCIYWIN KLQKEKKILS GEKEFERETR EIALKELEKE
RVQKEEELQV KEKLQEELRW RRTFLHAVDV VLDPDTAHPD LFLSEDRRSV RRCPFRHLGE
SVPDNPERFD SQPCVLGRES FASGKHYWEV EVENVIEWTV GVCRDSVERK GEVLLIPQNG
FWTLEMHKGQ YRAVSSPDRI LPLKESLCRV GVFLDYEAGD VSFYNMRDRS HIYTCPRSAF
SVPVRPFFRL GCEDSPIFIC PALTGANGVT VPEEGLTLHR VGTHQSL
