TM41_DROME
ID TM41_DROME Reviewed; 320 AA.
AC Q9VX39; B7Z102; Q95RT5;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 2.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Transmembrane protein 41 homolog;
DE AltName: Full=Protein stasimon;
GN Name=stas; ORFNames=CG8408;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=23063131; DOI=10.1016/j.cell.2012.09.012;
RA Lotti F., Imlach W.L., Saieva L., Beck E.S., Hao le T., Li D.K., Jiao W.,
RA Mentis G.Z., Beattie C.E., McCabe B.D., Pellizzoni L.;
RT "An SMN-dependent U12 splicing event essential for motor circuit
RT function.";
RL Cell 151:440-454(2012).
CC -!- FUNCTION: Required in cholinergic neurons, but not in motor neurons,
CC for normal neurotransmitter release by motor neurons. Involved in
CC muscle growth. {ECO:0000269|PubMed:23063131}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=A;
CC IsoId=Q9VX39-1; Sequence=Displayed;
CC Name=B;
CC IsoId=Q9VX39-2; Sequence=VSP_053425, VSP_053426;
CC -!- TISSUE SPECIFICITY: In embryos, strongly expressed in the nervous
CC system. {ECO:0000269|PubMed:23063131}.
CC -!- SIMILARITY: Belongs to the TMEM41 family. {ECO:0000305}.
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DR EMBL; AE014298; AAF48742.2; -; Genomic_DNA.
DR EMBL; AE014298; ACL82947.1; -; Genomic_DNA.
DR EMBL; AY061150; AAL28698.1; -; mRNA.
DR RefSeq; NP_001138217.1; NM_001144745.2. [Q9VX39-2]
DR RefSeq; NP_573225.1; NM_132997.3. [Q9VX39-1]
DR AlphaFoldDB; Q9VX39; -.
DR BioGRID; 59063; 1.
DR IntAct; Q9VX39; 13.
DR STRING; 7227.FBpp0074261; -.
DR TCDB; 9.B.27.1.10; the death effector domain a (deda) family.
DR PaxDb; Q9VX39; -.
DR PRIDE; Q9VX39; -.
DR DNASU; 32737; -.
DR EnsemblMetazoa; FBtr0074487; FBpp0074261; FBgn0030850. [Q9VX39-1]
DR EnsemblMetazoa; FBtr0290036; FBpp0288475; FBgn0030850. [Q9VX39-2]
DR GeneID; 32737; -.
DR KEGG; dme:Dmel_CG8408; -.
DR UCSC; CG8408-RA; d. melanogaster. [Q9VX39-1]
DR CTD; 32737; -.
DR FlyBase; FBgn0030850; stas.
DR VEuPathDB; VectorBase:FBgn0030850; -.
DR eggNOG; KOG3140; Eukaryota.
DR GeneTree; ENSGT00940000156956; -.
DR HOGENOM; CLU_038944_0_1_1; -.
DR InParanoid; Q9VX39; -.
DR OMA; CIKIPRD; -.
DR PhylomeDB; Q9VX39; -.
DR BioGRID-ORCS; 32737; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 32737; -.
DR PRO; PR:Q9VX39; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0030850; Expressed in cleaving embryo and 27 other tissues.
DR Genevisible; Q9VX39; DM.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0032224; P:positive regulation of synaptic transmission, cholinergic; IMP:FlyBase.
DR InterPro; IPR032816; SNARE_assoc.
DR InterPro; IPR045014; TM41A/B.
DR PANTHER; PTHR43220; PTHR43220; 1.
DR Pfam; PF09335; SNARE_assoc; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Neurogenesis; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..320
FT /note="Transmembrane protein 41 homolog"
FT /id="PRO_0000291946"
FT TRANSMEM 83..103
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 173..195
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 225..242
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 245..265
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 289..309
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 20..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 39..71
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 151..174
FT /note="FLQTFAIPGSLFLSILLGFLYKFP -> LYPFTKSKSTNPKYEKWHEKSVAD
FT (in isoform B)"
FT /evidence="ECO:0000305"
FT /id="VSP_053425"
FT VAR_SEQ 175..320
FT /note="Missing (in isoform B)"
FT /evidence="ECO:0000305"
FT /id="VSP_053426"
SQ SEQUENCE 320 AA; 35833 MW; FE27C59D6DCE536C CRC64;
MSYCSGVAIS ADEGITMRNG RAKALQEHSP DQVATPLLPQ VPPQEQQDLN PQQQQQQQQQ
QQATPQKQAM SADEKKATKK SLVIVAGIFV ASLVTMCYVY AIFPELNASE KQHLKIPRDI
QDAKMLAKVL DRYKDMYYFE VMFGVVVAYV FLQTFAIPGS LFLSILLGFL YKFPIALFLI
CFCSALGATL CYTLSNLVGR RLIRHFWPKK TSEWSKHVEE YRDSLFNYML FLRMTPILPN
WFINLASPVI GVPLHIFALG TFCGVAPPSV IAIQAGKTLQ KMTSSSEAFS WTSMGILMAC
ACASLLPGLL KNKFKHKKEA
