TM45A_HUMAN
ID TM45A_HUMAN Reviewed; 275 AA.
AC Q9NWC5; Q53YW5;
DT 12-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Transmembrane protein 45A;
DE AltName: Full=DNA polymerase-transactivated protein 4;
DE AltName: Full=Dermal papilla-derived protein 7;
GN Name=TMEM45A; Synonyms=DERP7, DNAPTP4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Hair follicle dermal papilla;
RA Ikeda A., Ukai Y., Yamashita M., Yoshimoto M.;
RT "Molecular cloning of a dermal papilla derived gene.";
RL Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Wang C., Cheng J., Lang Z., Ji D., Yang Y., Zhang L., Wu Y.;
RT "Screening and cloning of the target genes transactivated by hepatitis B
RT virus DNA polymerase using suppression subtractive hybridization (SSH)
RT technique.";
RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q9NWC5; P02652: APOA2; NbExp=3; IntAct=EBI-10823938, EBI-1171525;
CC Q9NWC5; Q8WVX3-2: C4orf3; NbExp=3; IntAct=EBI-10823938, EBI-12003442;
CC Q9NWC5; Q7Z2K6: ERMP1; NbExp=3; IntAct=EBI-10823938, EBI-10976398;
CC Q9NWC5; P48165: GJA8; NbExp=3; IntAct=EBI-10823938, EBI-17458373;
CC Q9NWC5; P24593: IGFBP5; NbExp=3; IntAct=EBI-10823938, EBI-720480;
CC Q9NWC5; P26678: PLN; NbExp=3; IntAct=EBI-10823938, EBI-692836;
CC Q9NWC5; Q8WWF3: SSMEM1; NbExp=3; IntAct=EBI-10823938, EBI-17280858;
CC Q9NWC5; Q96HH6: TMEM19; NbExp=3; IntAct=EBI-10823938, EBI-741829;
CC Q9NWC5; A5PKU2: TUSC5; NbExp=3; IntAct=EBI-10823938, EBI-11988865;
CC Q9NWC5; P0DTD8: 7b; Xeno; NbExp=3; IntAct=EBI-10823938, EBI-25475914;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TMEM45 family. {ECO:0000305}.
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DR EMBL; AB013911; BAB87801.1; -; mRNA.
DR EMBL; AY450392; AAR21085.1; -; mRNA.
DR EMBL; AK000996; BAA91458.1; -; mRNA.
DR EMBL; BC040355; AAH40355.1; -; mRNA.
DR CCDS; CCDS2937.1; -.
DR RefSeq; NP_060474.1; NM_018004.2.
DR PDB; 7OQZ; EM; 3.27 A; A/B/C/D=3-275.
DR PDBsum; 7OQZ; -.
DR AlphaFoldDB; Q9NWC5; -.
DR SMR; Q9NWC5; -.
DR BioGRID; 120393; 18.
DR IntAct; Q9NWC5; 12.
DR MINT; Q9NWC5; -.
DR STRING; 9606.ENSP00000319009; -.
DR iPTMnet; Q9NWC5; -.
DR PhosphoSitePlus; Q9NWC5; -.
DR BioMuta; TMEM45A; -.
DR DMDM; 28380044; -.
DR jPOST; Q9NWC5; -.
DR MassIVE; Q9NWC5; -.
DR MaxQB; Q9NWC5; -.
DR PaxDb; Q9NWC5; -.
DR PeptideAtlas; Q9NWC5; -.
DR PRIDE; Q9NWC5; -.
DR ProteomicsDB; 82926; -.
DR Antibodypedia; 15847; 44 antibodies from 13 providers.
DR DNASU; 55076; -.
DR Ensembl; ENST00000323523.8; ENSP00000319009.4; ENSG00000181458.10.
DR GeneID; 55076; -.
DR KEGG; hsa:55076; -.
DR MANE-Select; ENST00000323523.8; ENSP00000319009.4; NM_018004.3; NP_060474.1.
DR UCSC; uc003dtz.2; human.
DR CTD; 55076; -.
DR DisGeNET; 55076; -.
DR GeneCards; TMEM45A; -.
DR HGNC; HGNC:25480; TMEM45A.
DR HPA; ENSG00000181458; Tissue enriched (skin).
DR neXtProt; NX_Q9NWC5; -.
DR OpenTargets; ENSG00000181458; -.
DR PharmGKB; PA134868262; -.
DR VEuPathDB; HostDB:ENSG00000181458; -.
DR eggNOG; ENOG502QU0J; Eukaryota.
DR GeneTree; ENSGT00940000155530; -.
DR HOGENOM; CLU_059568_0_1_1; -.
DR InParanoid; Q9NWC5; -.
DR PhylomeDB; Q9NWC5; -.
DR TreeFam; TF328673; -.
DR PathwayCommons; Q9NWC5; -.
DR SignaLink; Q9NWC5; -.
DR BioGRID-ORCS; 55076; 10 hits in 1048 CRISPR screens.
DR ChiTaRS; TMEM45A; human.
DR GenomeRNAi; 55076; -.
DR Pharos; Q9NWC5; Tbio.
DR PRO; PR:Q9NWC5; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q9NWC5; protein.
DR Bgee; ENSG00000181458; Expressed in penis and 168 other tissues.
DR ExpressionAtlas; Q9NWC5; baseline and differential.
DR Genevisible; Q9NWC5; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR006904; DUF716.
DR InterPro; IPR042127; TMEM45.
DR PANTHER; PTHR16007; PTHR16007; 1.
DR Pfam; PF04819; DUF716; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..275
FT /note="Transmembrane protein 45A"
FT /id="PRO_0000072569"
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 51..71
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..170
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 218..238
FT /note="Helical"
FT /evidence="ECO:0000255"
FT HELIX 4..33
FT /evidence="ECO:0007829|PDB:7OQZ"
FT STRAND 34..40
FT /evidence="ECO:0007829|PDB:7OQZ"
FT HELIX 43..68
FT /evidence="ECO:0007829|PDB:7OQZ"
FT HELIX 91..114
FT /evidence="ECO:0007829|PDB:7OQZ"
FT HELIX 121..140
FT /evidence="ECO:0007829|PDB:7OQZ"
FT HELIX 147..172
FT /evidence="ECO:0007829|PDB:7OQZ"
FT HELIX 177..201
FT /evidence="ECO:0007829|PDB:7OQZ"
FT HELIX 215..250
FT /evidence="ECO:0007829|PDB:7OQZ"
SQ SEQUENCE 275 AA; 31680 MW; E005FF448116EC9E CRC64;
MGNFRGHALP GTFFFIIGLW WCTKSILKYI CKKQKRTCYL GSKTLFYRLE ILEGITIVGM
ALTGMAGEQF IPGGPHLMLY DYKQGHWNQL LGWHHFTMYF FFGLLGVADI LCFTISSLPV
SLTKLMLSNA LFVEAFIFYN HTHGREMLDI FVHQLLVLVV FLTGLVAFLE FLVRNNVLLE
LLRSSLILLQ GSWFFQIGFV LYPPSGGPAW DLMDHENILF LTICFCWHYA VTIVIVGMNY
AFITWLVKSR LKRLCSSEVG LLKNAEREQE SEEEM
