BT2A2_HUMAN
ID BT2A2_HUMAN Reviewed; 523 AA.
AC Q8WVV5; A6NM84; B4DE97; B4DQ01; E9PH07; O00480;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 2.
DT 03-AUG-2022, entry version 164.
DE RecName: Full=Butyrophilin subfamily 2 member A2;
DE Flags: Precursor;
GN Name=BTN2A2; Synonyms=BT2.2, BTF2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RX PubMed=9149941; DOI=10.1101/gr.7.5.441;
RA Ruddy D.A., Kronmal G.S., Lee V.K., Mintier G.A., Quintana L.,
RA Domingo R. Jr., Meyer N.C., Irrinki A., McClelland E.E., Fullan A.,
RA Mapa F.A., Moore T., Thomas W., Loeb D.B., Harmon C., Tsuchihashi Z.,
RA Wolff R.K., Schatzman R.C., Feder J.N.;
RT "A 1.1-Mb transcript map of the hereditary hemochromatosis locus.";
RL Genome Res. 7:441-456(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 4 AND 5).
RC TISSUE=Caudate nucleus, and Cerebellum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain, and Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Inhibits the proliferation of CD4 and CD8 T-cells activated
CC by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion.
CC {ECO:0000250}.
CC -!- INTERACTION:
CC Q8WVV5; Q13520: AQP6; NbExp=3; IntAct=EBI-8648738, EBI-13059134;
CC Q8WVV5; Q13323: BIK; NbExp=3; IntAct=EBI-8648738, EBI-700794;
CC Q8WVV5; P19397: CD53; NbExp=3; IntAct=EBI-8648738, EBI-6657396;
CC Q8WVV5; P11912: CD79A; NbExp=3; IntAct=EBI-8648738, EBI-7797864;
CC Q8WVV5; Q8N5K1: CISD2; NbExp=3; IntAct=EBI-8648738, EBI-1045797;
CC Q8WVV5; Q15125: EBP; NbExp=3; IntAct=EBI-8648738, EBI-3915253;
CC Q8WVV5; Q9GZR5: ELOVL4; NbExp=3; IntAct=EBI-8648738, EBI-18535450;
CC Q8WVV5; P54849: EMP1; NbExp=3; IntAct=EBI-8648738, EBI-4319440;
CC Q8WVV5; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-8648738, EBI-781551;
CC Q8WVV5; P34910-2: EVI2B; NbExp=3; IntAct=EBI-8648738, EBI-17640610;
CC Q8WVV5; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-8648738, EBI-18304435;
CC Q8WVV5; Q969F0: FATE1; NbExp=3; IntAct=EBI-8648738, EBI-743099;
CC Q8WVV5; O15552: FFAR2; NbExp=3; IntAct=EBI-8648738, EBI-2833872;
CC Q8WVV5; O75712: GJB3; NbExp=3; IntAct=EBI-8648738, EBI-3908586;
CC Q8WVV5; O15529: GPR42; NbExp=3; IntAct=EBI-8648738, EBI-18076404;
CC Q8WVV5; Q9NZD1: GPRC5D; NbExp=3; IntAct=EBI-8648738, EBI-13067820;
CC Q8WVV5; Q8TED1: GPX8; NbExp=3; IntAct=EBI-8648738, EBI-11721746;
CC Q8WVV5; Q9H2F3: HSD3B7; NbExp=3; IntAct=EBI-8648738, EBI-3918847;
CC Q8WVV5; P43628: KIR2DL3; NbExp=3; IntAct=EBI-8648738, EBI-8632435;
CC Q8WVV5; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-8648738, EBI-2820517;
CC Q8WVV5; Q9HC36: MRM3; NbExp=3; IntAct=EBI-8648738, EBI-1045440;
CC Q8WVV5; P15941-11: MUC1; NbExp=3; IntAct=EBI-8648738, EBI-17263240;
CC Q8WVV5; O00623: PEX12; NbExp=3; IntAct=EBI-8648738, EBI-594836;
CC Q8WVV5; P25788: PSMA3; NbExp=3; IntAct=EBI-8648738, EBI-348380;
CC Q8WVV5; Q9BY50: SEC11C; NbExp=3; IntAct=EBI-8648738, EBI-2855401;
CC Q8WVV5; Q3KNW5: SLC10A6; NbExp=3; IntAct=EBI-8648738, EBI-18159983;
CC Q8WVV5; Q13336-2: SLC14A1; NbExp=3; IntAct=EBI-8648738, EBI-19141793;
CC Q8WVV5; P43003: SLC1A3; NbExp=3; IntAct=EBI-8648738, EBI-359038;
CC Q8WVV5; O14863: SLC30A4; NbExp=3; IntAct=EBI-8648738, EBI-13918058;
CC Q8WVV5; Q9NP94: SLC39A2; NbExp=3; IntAct=EBI-8648738, EBI-12898013;
CC Q8WVV5; Q6ZMD2-2: SPNS3; NbExp=3; IntAct=EBI-8648738, EBI-17848320;
CC Q8WVV5; Q16623: STX1A; NbExp=3; IntAct=EBI-8648738, EBI-712466;
CC Q8WVV5; P21579: SYT1; NbExp=3; IntAct=EBI-8648738, EBI-524909;
CC Q8WVV5; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-8648738, EBI-8638294;
CC Q8WVV5; Q7Z7N9: TMEM179B; NbExp=3; IntAct=EBI-8648738, EBI-11724423;
CC Q8WVV5; Q96Q45-2: TMEM237; NbExp=5; IntAct=EBI-8648738, EBI-10982110;
CC Q8WVV5; Q4KMG9: TMEM52B; NbExp=3; IntAct=EBI-8648738, EBI-18178701;
CC Q8WVV5; Q9Y320: TMX2; NbExp=3; IntAct=EBI-8648738, EBI-6447886;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1;
CC IsoId=Q8WVV5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8WVV5-2; Sequence=VSP_012712, VSP_012713;
CC Name=3;
CC IsoId=Q8WVV5-3; Sequence=VSP_043562, VSP_043563, VSP_043564;
CC Name=4;
CC IsoId=Q8WVV5-4; Sequence=VSP_043561;
CC Name=5;
CC IsoId=Q8WVV5-5; Sequence=VSP_044861;
CC -!- TISSUE SPECIFICITY: Highly expressed in brain, bone marrow, small
CC intestine, muscle, spleen and pancreas. Moderate expression was seen in
CC lung, liver and kidney. {ECO:0000269|PubMed:9149941}.
CC -!- PTM: N-glycosylated. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. BTN/MOG family.
CC {ECO:0000305}.
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DR EMBL; U90550; AAB53428.1; -; mRNA.
DR EMBL; AK289883; BAF82572.1; -; mRNA.
DR EMBL; AK293526; BAG57008.1; -; mRNA.
DR EMBL; AK298570; BAG60763.1; -; mRNA.
DR EMBL; AL021917; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471087; EAW55565.1; -; Genomic_DNA.
DR EMBL; BC014021; AAH14021.1; -; mRNA.
DR EMBL; BC017497; AAH17497.1; -; mRNA.
DR CCDS; CCDS4606.1; -. [Q8WVV5-1]
DR CCDS; CCDS4607.1; -. [Q8WVV5-4]
DR CCDS; CCDS56401.1; -. [Q8WVV5-2]
DR CCDS; CCDS56402.1; -. [Q8WVV5-3]
DR CCDS; CCDS56403.1; -. [Q8WVV5-5]
DR RefSeq; NP_001184166.1; NM_001197237.1. [Q8WVV5-1]
DR RefSeq; NP_001184167.1; NM_001197238.1. [Q8WVV5-2]
DR RefSeq; NP_001184168.1; NM_001197239.1. [Q8WVV5-5]
DR RefSeq; NP_001184169.1; NM_001197240.1. [Q8WVV5-3]
DR RefSeq; NP_008926.2; NM_006995.4. [Q8WVV5-1]
DR RefSeq; NP_853509.1; NM_181531.2. [Q8WVV5-4]
DR RefSeq; XP_005248854.1; XM_005248797.3. [Q8WVV5-1]
DR RefSeq; XP_005248855.1; XM_005248798.4. [Q8WVV5-4]
DR RefSeq; XP_006715016.1; XM_006714953.3. [Q8WVV5-1]
DR RefSeq; XP_011512530.1; XM_011514228.2. [Q8WVV5-1]
DR RefSeq; XP_011512533.1; XM_011514231.2. [Q8WVV5-5]
DR RefSeq; XP_016865656.1; XM_017010167.1. [Q8WVV5-4]
DR AlphaFoldDB; Q8WVV5; -.
DR SMR; Q8WVV5; -.
DR BioGRID; 115658; 87.
DR IntAct; Q8WVV5; 61.
DR MINT; Q8WVV5; -.
DR STRING; 9606.ENSP00000349143; -.
DR GlyGen; Q8WVV5; 4 sites.
DR iPTMnet; Q8WVV5; -.
DR PhosphoSitePlus; Q8WVV5; -.
DR BioMuta; BTN2A2; -.
DR DMDM; 83288459; -.
DR EPD; Q8WVV5; -.
DR jPOST; Q8WVV5; -.
DR MassIVE; Q8WVV5; -.
DR MaxQB; Q8WVV5; -.
DR PaxDb; Q8WVV5; -.
DR PeptideAtlas; Q8WVV5; -.
DR PRIDE; Q8WVV5; -.
DR ProteomicsDB; 20433; -.
DR ProteomicsDB; 74823; -. [Q8WVV5-1]
DR ProteomicsDB; 74824; -. [Q8WVV5-2]
DR ProteomicsDB; 74825; -. [Q8WVV5-3]
DR ProteomicsDB; 74826; -. [Q8WVV5-4]
DR ABCD; Q8WVV5; 7 sequenced antibodies.
DR Antibodypedia; 44597; 135 antibodies from 19 providers.
DR DNASU; 10385; -.
DR Ensembl; ENST00000352867.6; ENSP00000337117.3; ENSG00000124508.17. [Q8WVV5-4]
DR Ensembl; ENST00000356709.9; ENSP00000349143.4; ENSG00000124508.17. [Q8WVV5-1]
DR Ensembl; ENST00000416795.6; ENSP00000399308.2; ENSG00000124508.17. [Q8WVV5-1]
DR Ensembl; ENST00000432533.6; ENSP00000394241.2; ENSG00000124508.17. [Q8WVV5-3]
DR Ensembl; ENST00000469230.5; ENSP00000417472.1; ENSG00000124508.17. [Q8WVV5-2]
DR Ensembl; ENST00000482536.5; ENSP00000419451.1; ENSG00000124508.17. [Q8WVV5-5]
DR GeneID; 10385; -.
DR KEGG; hsa:10385; -.
DR MANE-Select; ENST00000356709.9; ENSP00000349143.4; NM_006995.5; NP_008926.2.
DR UCSC; uc003nhq.4; human. [Q8WVV5-1]
DR CTD; 10385; -.
DR DisGeNET; 10385; -.
DR GeneCards; BTN2A2; -.
DR HGNC; HGNC:1137; BTN2A2.
DR HPA; ENSG00000124508; Low tissue specificity.
DR MIM; 613591; gene.
DR neXtProt; NX_Q8WVV5; -.
DR OpenTargets; ENSG00000124508; -.
DR PharmGKB; PA25457; -.
DR VEuPathDB; HostDB:ENSG00000124508; -.
DR eggNOG; ENOG502QSRZ; Eukaryota.
DR GeneTree; ENSGT00940000158017; -.
DR HOGENOM; CLU_013137_22_2_1; -.
DR InParanoid; Q8WVV5; -.
DR OMA; WAIRASS; -.
DR PhylomeDB; Q8WVV5; -.
DR TreeFam; TF331083; -.
DR PathwayCommons; Q8WVV5; -.
DR Reactome; R-HSA-8851680; Butyrophilin (BTN) family interactions.
DR SignaLink; Q8WVV5; -.
DR BioGRID-ORCS; 10385; 10 hits in 1071 CRISPR screens.
DR ChiTaRS; BTN2A2; human.
DR GeneWiki; Butyrophilin,_subfamily_2,_member_A2; -.
DR GenomeRNAi; 10385; -.
DR Pharos; Q8WVV5; Tdark.
DR PRO; PR:Q8WVV5; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q8WVV5; protein.
DR Bgee; ENSG00000124508; Expressed in epithelium of nasopharynx and 180 other tissues.
DR ExpressionAtlas; Q8WVV5; baseline and differential.
DR Genevisible; Q8WVV5; HS.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR GO; GO:0070371; P:ERK1 and ERK2 cascade; IEA:Ensembl.
DR GO; GO:0000082; P:G1/S transition of mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0046007; P:negative regulation of activated T cell proliferation; ISS:UniProtKB.
DR GO; GO:0001818; P:negative regulation of cytokine production; ISS:UniProtKB.
DR GO; GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
DR GO; GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0014067; P:negative regulation of phosphatidylinositol 3-kinase signaling; IEA:Ensembl.
DR GO; GO:0051898; P:negative regulation of protein kinase B signaling; IEA:Ensembl.
DR GO; GO:0050860; P:negative regulation of T cell receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0014065; P:phosphatidylinositol 3-kinase signaling; IEA:Ensembl.
DR GO; GO:0045591; P:positive regulation of regulatory T cell differentiation; IEA:Ensembl.
DR GO; GO:0043491; P:protein kinase B signaling; IEA:Ensembl.
DR GO; GO:0001817; P:regulation of cytokine production; IBA:GO_Central.
DR GO; GO:0050852; P:T cell receptor signaling pathway; IBA:GO_Central.
DR CDD; cd15819; SPRY_PRY_BTN1_2; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR037958; SPRY/PRY_BTN1/2.
DR InterPro; IPR003877; SPRY_dom.
DR Pfam; PF13765; PRY; 1.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF07686; V-set; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00409; IG; 1.
DR SMART; SM00406; IGv; 1.
DR SMART; SM00589; PRY; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF48726; SSF48726; 2.
DR SUPFAM; SSF49899; SSF49899; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Disulfide bond; Glycoprotein;
KW Immunoglobulin domain; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..32
FT /evidence="ECO:0000255"
FT CHAIN 33..523
FT /note="Butyrophilin subfamily 2 member A2"
FT /id="PRO_0000014530"
FT TOPO_DOM 33..265
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 266..286
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 287..523
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 34..145
FT /note="Ig-like V-type"
FT DOMAIN 153..234
FT /note="Ig-like C2-type"
FT DOMAIN 309..502
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
FT COILED 286..321
FT /evidence="ECO:0000255"
FT CARBOHYD 50
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 118
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 220
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 226
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 55..129
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VAR_SEQ 32..241
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_044861"
FT VAR_SEQ 32..147
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_043561"
FT VAR_SEQ 148..241
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_043562"
FT VAR_SEQ 327..350
FT /note="ADVVLDPDTAHPELFLSEDRRSVR -> GYELPGIRGPSWKRPLHGEPPSAF
FT (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_043563"
FT VAR_SEQ 327..336
FT /note="ADVVLDPDTA -> DVNLTGLRNT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_012712"
FT VAR_SEQ 337..523
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_012713"
FT VAR_SEQ 351..523
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_043564"
FT VARIANT 479
FT /note="P -> S (in dbSNP:rs16891646)"
FT /id="VAR_049829"
FT CONFLICT 243
FT /note="S -> P (in Ref. 2; BAG57008)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 523 AA; 59070 MW; 122099CE635F279D CRC64;
MEPAAALHFS LPASLLLLLL LLLLSLCALV SAQFTVVGPA NPILAMVGEN TTLRCHLSPE
KNAEDMEVRW FRSQFSPAVF VYKGGRERTE EQMEEYRGRI TFVSKDINRG SVALVIHNVT
AQENGIYRCY FQEGRSYDEA ILRLVVAGLG SKPLIEIKAQ EDGSIWLECI SGGWYPEPLT
VWRDPYGEVV PALKEVSIAD ADGLFMVTTA VIIRDKYVRN VSCSVNNTLL GQEKETVIFI
PESFMPSASP WMVALAVILT ASPWMVSMTV ILAVFIIFMA VSICCIKKLQ REKKILSGEK
KVEQEEKEIA QQLQEELRWR RTFLHAADVV LDPDTAHPEL FLSEDRRSVR RGPYRQRVPD
NPERFDSQPC VLGWESFASG KHYWEVEVEN VMVWTVGVCR HSVERKGEVL LIPQNGFWTL
EMFGNQYRAL SSPERILPLK ESLCRVGVFL DYEAGDVSFY NMRDRSHIYT CPRSAFTVPV
RPFFRLGSDD SPIFICPALT GASGVMVPEE GLKLHRVGTH QSL
