ID   TM45A_MOUSE             Reviewed;         273 AA.
AC   Q60774;
DT   12-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Transmembrane protein 45A;
DE   AltName: Full=19.5;
DE   AltName: Full=Dermal papilla-derived protein 7 homolog;
GN   Name=Tmem45a; Synonyms=Derp7;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1980600;
RA   MacLeod C.L., Fong A.M., Seal B.S., Walls L., Wilkinson M.F.;
RT   "Isolation of novel complementary DNA clones from T lymphoma cells: one
RT   encodes a putative multiple membrane-spanning protein.";
RL   Cell Growth Differ. 1:271-279(1990).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TMEM45 family. {ECO:0000305}.
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DR   EMBL; M32486; AAA37113.1; -; mRNA.
DR   CCDS; CCDS28226.1; -.
DR   PIR; I49441; I49441.
DR   AlphaFoldDB; Q60774; -.
DR   SMR; Q60774; -.
DR   STRING; 10090.ENSMUSP00000023435; -.
DR   iPTMnet; Q60774; -.
DR   PhosphoSitePlus; Q60774; -.
DR   PaxDb; Q60774; -.
DR   PeptideAtlas; Q60774; -.
DR   PRIDE; Q60774; -.
DR   ProteomicsDB; 259115; -.
DR   MGI; MGI:1913122; Tmem45a.
DR   eggNOG; ENOG502QU0J; Eukaryota.
DR   InParanoid; Q60774; -.
DR   PhylomeDB; Q60774; -.
DR   ChiTaRS; Tmem45a; mouse.
DR   PRO; PR:Q60774; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; Q60774; protein.
DR   GO; GO:0005887; C:integral component of plasma membrane; ISS:MGI.
DR   InterPro; IPR006904; DUF716.
DR   InterPro; IPR042127; TMEM45.
DR   PANTHER; PTHR16007; PTHR16007; 1.
DR   Pfam; PF04819; DUF716; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..273
FT                   /note="Transmembrane protein 45A"
FT                   /id="PRO_0000072570"
FT   TRANSMEM        8..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        108..131
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        153..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        217..236
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   273 AA;  31343 MW;  EC4671AEEE4DD244 CRC64;
     MGSFKGHALP GSFFFAMGFW WTMKNILKSV YKRQTRTCYL NSKTLLRRTE IWEGVVVLLM
     SLTGIAGEQF ISGGPALILH KDGQWNQILG WHHTTMYLFF GLQGITQIIC FTTNVLPLSS
     SKLMLSIAIF VETFMFYNHT HGREMIDIFV HQLLVFVGTF SGLVAFLEFL VKNNALLELL
     RCSLLMFQGT WFWQMAFVLY PPCGSATWNL SDIQNKMFLS MCFCWHYASI LILIGVKYAL
     ANWLVKSRLR KGCTSEVGLL KHADREQESE EEV