TM45B_HUMAN
ID TM45B_HUMAN Reviewed; 275 AA.
AC Q96B21; A8K2L8;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Transmembrane protein 45B;
GN Name=TMEM45B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon, and Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007;
RA Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,
RA Greff Z., Keri G., Stemmann O., Mann M.;
RT "Kinase-selective enrichment enables quantitative phosphoproteomics of the
RT kinome across the cell cycle.";
RL Mol. Cell 31:438-448(2008).
CC -!- INTERACTION:
CC Q96B21; Q86W74-2: ANKRD46; NbExp=3; IntAct=EBI-3923061, EBI-12109402;
CC Q96B21; P05090: APOD; NbExp=3; IntAct=EBI-3923061, EBI-715495;
CC Q96B21; Q9BQE5: APOL2; NbExp=3; IntAct=EBI-3923061, EBI-4290634;
CC Q96B21; P29972: AQP1; NbExp=3; IntAct=EBI-3923061, EBI-745213;
CC Q96B21; O95393: BMP10; NbExp=3; IntAct=EBI-3923061, EBI-3922513;
CC Q96B21; Q8WVX3-2: C4orf3; NbExp=3; IntAct=EBI-3923061, EBI-12003442;
CC Q96B21; Q06432: CACNG1; NbExp=3; IntAct=EBI-3923061, EBI-9686780;
CC Q96B21; O95674: CDS2; NbExp=3; IntAct=EBI-3923061, EBI-3913685;
CC Q96B21; O14569: CYB561D2; NbExp=3; IntAct=EBI-3923061, EBI-717654;
CC Q96B21; Q9UPQ8: DOLK; NbExp=3; IntAct=EBI-3923061, EBI-8645574;
CC Q96B21; Q92520: FAM3C; NbExp=3; IntAct=EBI-3923061, EBI-2876774;
CC Q96B21; Q14318: FKBP8; NbExp=3; IntAct=EBI-3923061, EBI-724839;
CC Q96B21; Q8WWP7: GIMAP1; NbExp=3; IntAct=EBI-3923061, EBI-11991950;
CC Q96B21; Q9Y5U4: INSIG2; NbExp=3; IntAct=EBI-3923061, EBI-8503746;
CC Q96B21; O43561-2: LAT; NbExp=3; IntAct=EBI-3923061, EBI-8070286;
CC Q96B21; P42857: NSG1; NbExp=3; IntAct=EBI-3923061, EBI-6380741;
CC Q96B21; P26678: PLN; NbExp=3; IntAct=EBI-3923061, EBI-692836;
CC Q96B21; P60201-2: PLP1; NbExp=3; IntAct=EBI-3923061, EBI-12188331;
CC Q96B21; Q5VZY2: PLPP4; NbExp=3; IntAct=EBI-3923061, EBI-10485931;
CC Q96B21; Q96IW7: SEC22A; NbExp=3; IntAct=EBI-3923061, EBI-8652744;
CC Q96B21; Q15436: SEC23A; NbExp=3; IntAct=EBI-3923061, EBI-81088;
CC Q96B21; Q0VAQ4: SMAGP; NbExp=3; IntAct=EBI-3923061, EBI-10226799;
CC Q96B21; B2RUZ4: SMIM1; NbExp=3; IntAct=EBI-3923061, EBI-12188413;
CC Q96B21; Q6UX34: SNORC; NbExp=3; IntAct=EBI-3923061, EBI-11957067;
CC Q96B21; O43759-2: SYNGR1; NbExp=3; IntAct=EBI-3923061, EBI-12187159;
CC Q96B21; Q5BJH2-2: TMEM128; NbExp=3; IntAct=EBI-3923061, EBI-10694905;
CC Q96B21; A2RU14: TMEM218; NbExp=3; IntAct=EBI-3923061, EBI-10173151;
CC Q96B21; Q8NBD8: TMEM229B; NbExp=3; IntAct=EBI-3923061, EBI-12195227;
CC Q96B21; Q9BU79: TMEM243; NbExp=3; IntAct=EBI-3923061, EBI-12887458;
CC Q96B21; Q8TBM7: TMEM254; NbExp=3; IntAct=EBI-3923061, EBI-11956809;
CC Q96B21; Q9H2L4: TMEM60; NbExp=3; IntAct=EBI-3923061, EBI-2852148;
CC Q96B21; Q5BJF2: TMEM97; NbExp=3; IntAct=EBI-3923061, EBI-12111910;
CC Q96B21; O14798: TNFRSF10C; NbExp=3; IntAct=EBI-3923061, EBI-717441;
CC Q96B21; Q9NSU2-1: TREX1; NbExp=3; IntAct=EBI-3923061, EBI-16746122;
CC Q96B21; Q86UF1: TSPAN33; NbExp=3; IntAct=EBI-3923061, EBI-12045841;
CC Q96B21; Q5BVD1: TTMP; NbExp=3; IntAct=EBI-3923061, EBI-10243654;
CC Q96B21; O75841: UPK1B; NbExp=3; IntAct=EBI-3923061, EBI-12237619;
CC Q96B21; O95183: VAMP5; NbExp=3; IntAct=EBI-3923061, EBI-10191195;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TMEM45 family. {ECO:0000305}.
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DR EMBL; AK098106; BAC05235.1; -; mRNA.
DR EMBL; AK290283; BAF82972.1; -; mRNA.
DR EMBL; AK292058; BAF84747.1; -; mRNA.
DR EMBL; BC016153; AAH16153.1; -; mRNA.
DR CCDS; CCDS8482.1; -.
DR RefSeq; NP_001318139.1; NM_001331210.1.
DR RefSeq; NP_001318140.1; NM_001331211.1.
DR RefSeq; NP_001318141.1; NM_001331212.1.
DR RefSeq; NP_620143.1; NM_138788.4.
DR RefSeq; XP_016872677.1; XM_017017188.1.
DR RefSeq; XP_016872678.1; XM_017017189.1.
DR AlphaFoldDB; Q96B21; -.
DR SMR; Q96B21; -.
DR BioGRID; 125675; 46.
DR IntAct; Q96B21; 40.
DR STRING; 9606.ENSP00000281441; -.
DR iPTMnet; Q96B21; -.
DR PhosphoSitePlus; Q96B21; -.
DR BioMuta; TMEM45B; -.
DR DMDM; 74731190; -.
DR jPOST; Q96B21; -.
DR MassIVE; Q96B21; -.
DR MaxQB; Q96B21; -.
DR PaxDb; Q96B21; -.
DR PeptideAtlas; Q96B21; -.
DR PRIDE; Q96B21; -.
DR ProteomicsDB; 76035; -.
DR Antibodypedia; 19209; 8 antibodies from 7 providers.
DR DNASU; 120224; -.
DR Ensembl; ENST00000281441.8; ENSP00000281441.3; ENSG00000151715.8.
DR Ensembl; ENST00000524567.1; ENSP00000436293.1; ENSG00000151715.8.
DR GeneID; 120224; -.
DR KEGG; hsa:120224; -.
DR MANE-Select; ENST00000281441.8; ENSP00000281441.3; NM_138788.5; NP_620143.1.
DR UCSC; uc001qfe.2; human.
DR CTD; 120224; -.
DR DisGeNET; 120224; -.
DR GeneCards; TMEM45B; -.
DR HGNC; HGNC:25194; TMEM45B.
DR HPA; ENSG00000151715; Tissue enhanced (esophagus, intestine).
DR neXtProt; NX_Q96B21; -.
DR OpenTargets; ENSG00000151715; -.
DR PharmGKB; PA134909603; -.
DR VEuPathDB; HostDB:ENSG00000151715; -.
DR eggNOG; ENOG502QU0J; Eukaryota.
DR GeneTree; ENSGT00940000157181; -.
DR HOGENOM; CLU_059568_0_0_1; -.
DR InParanoid; Q96B21; -.
DR OMA; FGAPEWD; -.
DR OrthoDB; 1297629at2759; -.
DR PhylomeDB; Q96B21; -.
DR TreeFam; TF328673; -.
DR PathwayCommons; Q96B21; -.
DR SignaLink; Q96B21; -.
DR BioGRID-ORCS; 120224; 12 hits in 1067 CRISPR screens.
DR ChiTaRS; TMEM45B; human.
DR GenomeRNAi; 120224; -.
DR Pharos; Q96B21; Tbio.
DR PRO; PR:Q96B21; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q96B21; protein.
DR Bgee; ENSG00000151715; Expressed in ileal mucosa and 144 other tissues.
DR Genevisible; Q96B21; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR006904; DUF716.
DR InterPro; IPR042127; TMEM45.
DR PANTHER; PTHR16007; PTHR16007; 1.
DR Pfam; PF04819; DUF716; 1.
PE 1: Evidence at protein level;
KW Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..275
FT /note="Transmembrane protein 45B"
FT /id="PRO_0000271199"
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 47..67
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 116..136
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..200
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 212..232
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 270
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q497B2"
FT MOD_RES 272
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8VCZ2"
FT VARIANT 59
FT /note="T -> I (in dbSNP:rs558813)"
FT /id="VAR_029866"
SQ SEQUENCE 275 AA; 31826 MW; DB8514C1E5005216 CRC64;
MANFKGHALP GSFFLIIGLC WSVKYPLKYF SHTRKNSPLH YYQRLEIVEA AIRTLFSVTG
ILAEQFVPDG PHLHLYHENH WIKLMNWQHS TMYLFFAVSG IVDMLTYLVS HVPLGVDRLV
MAVAVFMEGF LFYYHVHNRP PLDQHIHSLL LYALFGGCVS ISLEVIFRDH IVLELFRTSL
IILQGTWFWQ IGFVLFPPFG TPEWDQKDDA NLMFITMCFC WHYLAALSIV AVNYSLVYCL
LTRMKRHGRG EIIGIQKLNS DDTYQTALLS GSDEE
