TM45B_MOUSE
ID TM45B_MOUSE Reviewed; 278 AA.
AC Q8VCZ2; Q3UNB2;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Transmembrane protein 45B;
GN Name=Tmem45b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Gall bladder;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Colon, and Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-275, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, and Kidney;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TMEM45 family. {ECO:0000305}.
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DR EMBL; AK144325; BAE25835.1; -; mRNA.
DR EMBL; BC018222; AAH18222.1; -; mRNA.
DR EMBL; BC026654; AAH26654.1; -; mRNA.
DR CCDS; CCDS22950.1; -.
DR RefSeq; NP_659185.1; NM_144936.1.
DR RefSeq; XP_011240784.1; XM_011242482.2.
DR AlphaFoldDB; Q8VCZ2; -.
DR SMR; Q8VCZ2; -.
DR STRING; 10090.ENSMUSP00000042313; -.
DR iPTMnet; Q8VCZ2; -.
DR PhosphoSitePlus; Q8VCZ2; -.
DR jPOST; Q8VCZ2; -.
DR PaxDb; Q8VCZ2; -.
DR PeptideAtlas; Q8VCZ2; -.
DR PRIDE; Q8VCZ2; -.
DR ProteomicsDB; 262830; -.
DR Antibodypedia; 19209; 8 antibodies from 7 providers.
DR DNASU; 235135; -.
DR Ensembl; ENSMUST00000048050; ENSMUSP00000042313; ENSMUSG00000041737.
DR GeneID; 235135; -.
DR KEGG; mmu:235135; -.
DR UCSC; uc009ort.1; mouse.
DR CTD; 120224; -.
DR MGI; MGI:2384574; Tmem45b.
DR VEuPathDB; HostDB:ENSMUSG00000041737; -.
DR eggNOG; ENOG502QU0J; Eukaryota.
DR GeneTree; ENSGT00940000157181; -.
DR HOGENOM; CLU_059568_0_0_1; -.
DR InParanoid; Q8VCZ2; -.
DR OMA; MQILDFP; -.
DR OrthoDB; 1297629at2759; -.
DR PhylomeDB; Q8VCZ2; -.
DR TreeFam; TF328673; -.
DR BioGRID-ORCS; 235135; 4 hits in 71 CRISPR screens.
DR ChiTaRS; Tmem45b; mouse.
DR PRO; PR:Q8VCZ2; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q8VCZ2; protein.
DR Bgee; ENSMUSG00000041737; Expressed in left colon and 137 other tissues.
DR ExpressionAtlas; Q8VCZ2; baseline and differential.
DR Genevisible; Q8VCZ2; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR006904; DUF716.
DR InterPro; IPR042127; TMEM45.
DR PANTHER; PTHR16007; PTHR16007; 1.
DR Pfam; PF04819; DUF716; 1.
PE 1: Evidence at protein level;
KW Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..278
FT /note="Transmembrane protein 45B"
FT /id="PRO_0000271200"
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 49..69
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 95..115
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 149..169
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 183..203
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 215..235
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 273
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q497B2"
FT MOD_RES 275
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CONFLICT 157
FT /note="L -> P (in Ref. 1; BAE25835)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 278 AA; 32388 MW; 8A4D44E53D82A8F1 CRC64;
MANFKGHALP GSFFLIVGLW WSVKYPLKYF HHKGLKNNRL SRQQERIEII EGAVKTLFAI
IGILAEQFVP DGPHLHLYHE NQWVKLMNWQ HSTMYLFFGV SGLMDMITYL YFHIVPLGLD
RVVLAMAVFI EGFLFYFHVH NRPPLDQHIH SLLLFGLFGA AVSISLEVIL RDNIVLELFR
TSLLILQGTW FWQIGFVLFP PFGRPEWDQK DMDNIMFITM CFCWHYLVAL CIVAINYSLV
YCFLTRVKRR AEGEIIGIQK LKSDHTYQSA LLSGSDEE
