TM45B_RAT
ID TM45B_RAT Reviewed; 278 AA.
AC Q497B2;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2005, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Transmembrane protein 45B;
GN Name=Tmem45b;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Prostate;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-273 AND SER-275, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TMEM45 family. {ECO:0000305}.
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DR EMBL; BC100635; AAI00636.1; -; mRNA.
DR RefSeq; NP_001028239.1; NM_001033067.1.
DR RefSeq; XP_017451104.1; XM_017595615.1.
DR AlphaFoldDB; Q497B2; -.
DR SMR; Q497B2; -.
DR STRING; 10116.ENSRNOP00000011329; -.
DR iPTMnet; Q497B2; -.
DR PhosphoSitePlus; Q497B2; -.
DR PaxDb; Q497B2; -.
DR Ensembl; ENSRNOT00000011329; ENSRNOP00000011329; ENSRNOG00000008515.
DR GeneID; 315524; -.
DR KEGG; rno:315524; -.
DR UCSC; RGD:1305586; rat.
DR CTD; 120224; -.
DR RGD; 1305586; Tmem45b.
DR eggNOG; ENOG502QU0J; Eukaryota.
DR GeneTree; ENSGT00940000157181; -.
DR HOGENOM; CLU_059568_0_0_1; -.
DR InParanoid; Q497B2; -.
DR OMA; MQILDFP; -.
DR OrthoDB; 1297629at2759; -.
DR PhylomeDB; Q497B2; -.
DR TreeFam; TF328673; -.
DR PRO; PR:Q497B2; -.
DR Proteomes; UP000002494; Chromosome 8.
DR Bgee; ENSRNOG00000008515; Expressed in jejunum and 14 other tissues.
DR Genevisible; Q497B2; RN.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR006904; DUF716.
DR InterPro; IPR042127; TMEM45.
DR PANTHER; PTHR16007; PTHR16007; 1.
DR Pfam; PF04819; DUF716; 1.
PE 1: Evidence at protein level;
KW Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..278
FT /note="Transmembrane protein 45B"
FT /id="PRO_0000271201"
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 49..69
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 95..115
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 149..169
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 183..203
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 215..235
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 273
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 275
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
SQ SEQUENCE 278 AA; 32338 MW; 8127E2670CE0ECF7 CRC64;
MANFKGHALP GSFFLIFGLW WSVKYPLKYF HQKGLKKNRL SLQQQRIEII EGAVKALFAV
IGILAEQFVP DGPHLHLYHE NQWTKLMNWQ HSTMYLFFGV SGIIDMLTYL YFNIVPLGLD
RVVLAMAVFV EGFLFYFHVH GRPPLDQHIH SLLLFSLFGA TISICLEVIL RDNIVLELFR
TTLLILQGTW FWQIGFVLFP PFGTPEWDQK DMDNVMFITM CFCWHYLVAL CITAINYSLV
YCFLTRVRRR AEGEIIGIQK LKSDHTYQST LLSGSDEE
