ID   TM45B_XENTR             Reviewed;         280 AA.
AC   Q5XGD7;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Transmembrane protein 45B;
GN   Name=tmem45b; ORFNames=TNeu104l01.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Neurula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TMEM45 family. {ECO:0000305}.
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DR   EMBL; CR760159; CAJ83023.1; -; mRNA.
DR   EMBL; BC084505; AAH84505.1; -; mRNA.
DR   RefSeq; NP_001011108.1; NM_001011108.1.
DR   RefSeq; XP_017950852.1; XM_018095363.1.
DR   AlphaFoldDB; Q5XGD7; -.
DR   SMR; Q5XGD7; -.
DR   STRING; 8364.ENSXETP00000008822; -.
DR   PaxDb; Q5XGD7; -.
DR   DNASU; 496521; -.
DR   Ensembl; ENSXETT00000008822; ENSXETP00000008822; ENSXETG00000004079.
DR   GeneID; 496521; -.
DR   KEGG; xtr:496521; -.
DR   CTD; 120224; -.
DR   Xenbase; XB-GENE-5730663; tmem45b.
DR   eggNOG; ENOG502QU0J; Eukaryota.
DR   InParanoid; Q5XGD7; -.
DR   OrthoDB; 1297629at2759; -.
DR   Proteomes; UP000008143; Chromosome 7.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000004079; Expressed in ovary and 9 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR006904; DUF716.
DR   InterPro; IPR042127; TMEM45.
DR   PANTHER; PTHR16007; PTHR16007; 1.
DR   Pfam; PF04819; DUF716; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..280
FT                   /note="Transmembrane protein 45B"
FT                   /id="PRO_0000271204"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        96..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        120..140
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        184..204
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        216..236
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   280 AA;  31799 MW;  F92D36C78A469F87 CRC64;
     MANFKGHALP GSFFLVFGLW WSVKYPLKYL NSKVKGNCRS NKCYERLELI EGILKAAFAL
     IGILAEQFVP DGPHMHLVNG EDHSWVKLMN WQHTTMYLFY GISGVVDILT FLPLNLPRGL
     DRLSLGIAVI IEGLLFYYHV HNRPALDQHI HSLLLIAVFG GAISIMIEVF MRNDIVLELF
     RSSLTILQGT WFWQIGFVLY PLGGAPEWDQ TDHGNVMFIT MCFCWHYAVA LLIMAINYSL
     VYCCVKRHKK LSSVVDNSLK KINSNKTEVE ASLLAGSDEE