TM50A_MOUSE
ID TM50A_MOUSE Reviewed; 157 AA.
AC Q9CXL1;
DT 01-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Transmembrane protein 50A;
DE AltName: Full=Small membrane protein 1;
GN Name=Tmem50a; Synonyms=Smp1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=12459264; DOI=10.1016/s0378-1119(02)01054-5;
RA Kumada M., Iwamoto S., Kamesaki T., Okuda H., Kajii E.;
RT "Entire sequence of a mouse chromosomal segment containing the gene Rhced
RT and a comparative analysis of the homologous human sequence.";
RL Gene 299:165-172(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryonic head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Heart, and Lung;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the UPF0220 family. {ECO:0000305}.
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DR EMBL; AB076248; BAC21152.1; -; Genomic_DNA.
DR EMBL; AK014282; BAB29242.1; -; mRNA.
DR CCDS; CCDS18779.1; -.
DR RefSeq; NP_082211.1; NM_027935.2.
DR RefSeq; XP_006539244.1; XM_006539181.2.
DR AlphaFoldDB; Q9CXL1; -.
DR STRING; 10090.ENSMUSP00000030626; -.
DR PhosphoSitePlus; Q9CXL1; -.
DR SwissPalm; Q9CXL1; -.
DR MaxQB; Q9CXL1; -.
DR PaxDb; Q9CXL1; -.
DR PRIDE; Q9CXL1; -.
DR ProteomicsDB; 262831; -.
DR Antibodypedia; 77930; 5 antibodies from 5 providers.
DR DNASU; 71817; -.
DR Ensembl; ENSMUST00000030626; ENSMUSP00000030626; ENSMUSG00000028822.
DR Ensembl; ENSMUST00000105863; ENSMUSP00000101489; ENSMUSG00000028822.
DR GeneID; 71817; -.
DR KEGG; mmu:71817; -.
DR UCSC; uc008vfv.1; mouse.
DR CTD; 23585; -.
DR MGI; MGI:1919067; Tmem50a.
DR VEuPathDB; HostDB:ENSMUSG00000028822; -.
DR eggNOG; KOG3393; Eukaryota.
DR GeneTree; ENSGT00940000157715; -.
DR HOGENOM; CLU_096876_1_0_1; -.
DR InParanoid; Q9CXL1; -.
DR OMA; WILFADF; -.
DR OrthoDB; 1422977at2759; -.
DR PhylomeDB; Q9CXL1; -.
DR TreeFam; TF300282; -.
DR BioGRID-ORCS; 71817; 3 hits in 72 CRISPR screens.
DR ChiTaRS; Tmem50a; mouse.
DR PRO; PR:Q9CXL1; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q9CXL1; protein.
DR Bgee; ENSMUSG00000028822; Expressed in adrenal gland and 222 other tissues.
DR ExpressionAtlas; Q9CXL1; baseline and differential.
DR Genevisible; Q9CXL1; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI.
DR GO; GO:0097386; C:glial cell projection; IDA:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043025; C:neuronal cell body; IDA:MGI.
DR GO; GO:0032511; P:late endosome to vacuole transport via multivesicular body sorting pathway; IBA:GO_Central.
DR InterPro; IPR007919; UPF0220.
DR PANTHER; PTHR13180; PTHR13180; 1.
DR Pfam; PF05255; UPF0220; 1.
PE 1: Evidence at protein level;
KW Acetylation; Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:O95807"
FT CHAIN 2..157
FT /note="Transmembrane protein 50A"
FT /id="PRO_0000174182"
FT TRANSMEM 26..46
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..78
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 95..115
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 126..146
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0000250|UniProtKB:O95807"
FT MOD_RES 2
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O95807"
SQ SEQUENCE 157 AA; 17495 MW; CA497CD26D27E82F CRC64;
MSGFLEGSRC SECMDWGEKR NTIASIAAGV LFFTGWWIII DAAVMYPRMD QFNHSYHTCG
VIATIAFLMI NAVSNGQVRG DSYSEGCLGQ TGARIWLFIG FMLAFGSLIA SMWILFGGYV
AKEKDVVYPG IAVFFQNAFI FFGGLVFKFG RTEDLWQ
