ID   TM50B_BOVIN             Reviewed;         158 AA.
AC   Q3SZL9;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Transmembrane protein 50B;
GN   Name=TMEM50B;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: May form homotrimers or homodimers.
CC       {ECO:0000250|UniProtKB:Q9D1X9}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q9D1X9}; Multi-pass membrane protein
CC       {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9D1X9};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the UPF0220 family. {ECO:0000305}.
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DR   EMBL; BC102794; AAI02795.1; -; mRNA.
DR   RefSeq; NP_001029958.1; NM_001034786.2.
DR   AlphaFoldDB; Q3SZL9; -.
DR   STRING; 9913.ENSBTAP00000001660; -.
DR   PaxDb; Q3SZL9; -.
DR   Ensembl; ENSBTAT00000001660; ENSBTAP00000001660; ENSBTAG00000001258.
DR   GeneID; 615627; -.
DR   KEGG; bta:615627; -.
DR   CTD; 757; -.
DR   VEuPathDB; HostDB:ENSBTAG00000001258; -.
DR   VGNC; VGNC:36093; TMEM50B.
DR   eggNOG; KOG3393; Eukaryota.
DR   GeneTree; ENSGT00940000155131; -.
DR   HOGENOM; CLU_096876_1_0_1; -.
DR   InParanoid; Q3SZL9; -.
DR   OMA; LWIMFAD; -.
DR   OrthoDB; 1422977at2759; -.
DR   TreeFam; TF300282; -.
DR   Proteomes; UP000009136; Chromosome 1.
DR   Bgee; ENSBTAG00000001258; Expressed in spermatocyte and 103 other tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0032511; P:late endosome to vacuole transport via multivesicular body sorting pathway; IBA:GO_Central.
DR   InterPro; IPR007919; UPF0220.
DR   PANTHER; PTHR13180; PTHR13180; 1.
DR   Pfam; PF05255; UPF0220; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Endoplasmic reticulum; Golgi apparatus; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:P56557"
FT   CHAIN           2..158
FT                   /note="Transmembrane protein 50B"
FT                   /id="PRO_0000328499"
FT   TRANSMEM        28..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        56..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        128..148
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:P56557"
SQ   SEQUENCE   158 AA;  17936 MW;  515ABB6AAA817DEB CRC64;
     MAGFLDNFRW PECECIDWSE RRNAVASVVA GILFFTGWWI MIDAAVVYPK PEQLNHAFHT
     CGVFSTLAFF MINAVSNAQV RGDSYESGCL GRTGARVWLF IGFMLMFGSL IASMWILFGA
     YVTQNTDVYP GLAVFFQNAL IFFSTLIYKF GRTEELWT