ID   TM50B_PONAB             Reviewed;         158 AA.
AC   Q5R4C3;
DT   27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 52.
DE   RecName: Full=Transmembrane protein 50B;
GN   Name=TMEM50B;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: May form homotrimers or homodimers.
CC       {ECO:0000250|UniProtKB:Q9D1X9}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q9D1X9}; Multi-pass membrane protein
CC       {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9D1X9};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the UPF0220 family. {ECO:0000305}.
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DR   EMBL; CR861329; CAH93393.1; -; mRNA.
DR   RefSeq; NP_001126991.1; NM_001133519.1.
DR   AlphaFoldDB; Q5R4C3; -.
DR   Ensembl; ENSPPYT00000013203; ENSPPYP00000012698; ENSPPYG00000011377.
DR   GeneID; 100174014; -.
DR   KEGG; pon:100174014; -.
DR   CTD; 757; -.
DR   GeneTree; ENSGT00940000155131; -.
DR   InParanoid; Q5R4C3; -.
DR   OrthoDB; 1422977at2759; -.
DR   Proteomes; UP000001595; Chromosome 21.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR007919; UPF0220.
DR   PANTHER; PTHR13180; PTHR13180; 1.
DR   Pfam; PF05255; UPF0220; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Endoplasmic reticulum; Golgi apparatus; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:P56557"
FT   CHAIN           2..158
FT                   /note="Transmembrane protein 50B"
FT                   /id="PRO_0000174185"
FT   TRANSMEM        28..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        56..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        128..148
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:P56557"
SQ   SEQUENCE   158 AA;  17936 MW;  515ABB6AAA817DEB CRC64;
     MAGFLDNFRW PECECIDWSE RRNAVASVVA GILFFTGWWI MIDAAVVYPK PEQLNHAFHT
     CGVFSTLAFF MINAVSNAQV RGDSYESGCL GRTGARVWLF IGFMLMFGSL IASMWILFGA
     YVTQNTDVYP GLAVFFQNAL IFFSTLIYKF GRTEELWT