TM52B_HUMAN
ID TM52B_HUMAN Reviewed; 183 AA.
AC Q4KMG9; Q96NA7;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 02-AUG-2005, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Transmembrane protein 52B;
DE Flags: Precursor;
GN Name=TMEM52B; Synonyms=C12orf59; ORFNames=UNQ5927/PRO19821;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Kidney;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
CC -!- INTERACTION:
CC Q4KMG9; Q92685: ALG3; NbExp=3; IntAct=EBI-18178701, EBI-2848814;
CC Q4KMG9; P05090: APOD; NbExp=3; IntAct=EBI-18178701, EBI-715495;
CC Q4KMG9; Q9BQE5: APOL2; NbExp=3; IntAct=EBI-18178701, EBI-4290634;
CC Q4KMG9; O95236-2: APOL3; NbExp=3; IntAct=EBI-18178701, EBI-11976321;
CC Q4KMG9; O15155: BET1; NbExp=3; IntAct=EBI-18178701, EBI-749204;
CC Q4KMG9; Q8WVV5: BTN2A2; NbExp=3; IntAct=EBI-18178701, EBI-8648738;
CC Q4KMG9; Q8N6F1-2: CLDN19; NbExp=3; IntAct=EBI-18178701, EBI-12256978;
CC Q4KMG9; O14493: CLDN4; NbExp=3; IntAct=EBI-18178701, EBI-9316372;
CC Q4KMG9; O95406: CNIH1; NbExp=3; IntAct=EBI-18178701, EBI-12172273;
CC Q4KMG9; Q8TBE1: CNIH3; NbExp=3; IntAct=EBI-18178701, EBI-12208021;
CC Q4KMG9; Q8N6G5: CSGALNACT2; NbExp=3; IntAct=EBI-18178701, EBI-10267100;
CC Q4KMG9; Q96LL9: DNAJC30; NbExp=3; IntAct=EBI-18178701, EBI-8639143;
CC Q4KMG9; P50402: EMD; NbExp=3; IntAct=EBI-18178701, EBI-489887;
CC Q4KMG9; Q14802-3: FXYD3; NbExp=3; IntAct=EBI-18178701, EBI-12175685;
CC Q4KMG9; P01350: GAST; NbExp=3; IntAct=EBI-18178701, EBI-3436637;
CC Q4KMG9; O00155: GPR25; NbExp=3; IntAct=EBI-18178701, EBI-10178951;
CC Q4KMG9; O60883: GPR37L1; NbExp=3; IntAct=EBI-18178701, EBI-2927498;
CC Q4KMG9; P24593: IGFBP5; NbExp=3; IntAct=EBI-18178701, EBI-720480;
CC Q4KMG9; Q9Y5U4: INSIG2; NbExp=3; IntAct=EBI-18178701, EBI-8503746;
CC Q4KMG9; P11215: ITGAM; NbExp=3; IntAct=EBI-18178701, EBI-2568251;
CC Q4KMG9; Q8N5M9: JAGN1; NbExp=3; IntAct=EBI-18178701, EBI-10266796;
CC Q4KMG9; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-18178701, EBI-2820517;
CC Q4KMG9; Q9UBY5: LPAR3; NbExp=3; IntAct=EBI-18178701, EBI-12033434;
CC Q4KMG9; Q16873: LTC4S; NbExp=3; IntAct=EBI-18178701, EBI-12241118;
CC Q4KMG9; P21145: MAL; NbExp=3; IntAct=EBI-18178701, EBI-3932027;
CC Q4KMG9; Q9P0N8: MARCHF2; NbExp=3; IntAct=EBI-18178701, EBI-10317612;
CC Q4KMG9; P30301: MIP; NbExp=3; IntAct=EBI-18178701, EBI-8449636;
CC Q4KMG9; Q5J8X5: MS4A13; NbExp=3; IntAct=EBI-18178701, EBI-12070086;
CC Q4KMG9; Q9NZG7: NINJ2; NbExp=3; IntAct=EBI-18178701, EBI-10317425;
CC Q4KMG9; Q8IXM6: NRM; NbExp=3; IntAct=EBI-18178701, EBI-10262547;
CC Q4KMG9; P42857: NSG1; NbExp=3; IntAct=EBI-18178701, EBI-6380741;
CC Q4KMG9; Q9P0S3: ORMDL1; NbExp=3; IntAct=EBI-18178701, EBI-1054848;
CC Q4KMG9; I3L0A0: PEDS1-UBE2V1; NbExp=3; IntAct=EBI-18178701, EBI-12213001;
CC Q4KMG9; Q9UHJ9-5: PGAP2; NbExp=3; IntAct=EBI-18178701, EBI-12092917;
CC Q4KMG9; P26678: PLN; NbExp=3; IntAct=EBI-18178701, EBI-692836;
CC Q4KMG9; P60201-2: PLP1; NbExp=3; IntAct=EBI-18178701, EBI-12188331;
CC Q4KMG9; Q5QGT7: RTP2; NbExp=3; IntAct=EBI-18178701, EBI-10244780;
CC Q4KMG9; Q96IW7: SEC22A; NbExp=3; IntAct=EBI-18178701, EBI-8652744;
CC Q4KMG9; Q9Y6X1: SERP1; NbExp=3; IntAct=EBI-18178701, EBI-10329948;
CC Q4KMG9; Q9BRI3: SLC30A2; NbExp=3; IntAct=EBI-18178701, EBI-8644112;
CC Q4KMG9; Q8IWU4: SLC30A8; NbExp=3; IntAct=EBI-18178701, EBI-10262251;
CC Q4KMG9; Q96G79: SLC35A4; NbExp=3; IntAct=EBI-18178701, EBI-12363689;
CC Q4KMG9; Q969S0: SLC35B4; NbExp=3; IntAct=EBI-18178701, EBI-10281213;
CC Q4KMG9; Q9NVC3: SLC38A7; NbExp=3; IntAct=EBI-18178701, EBI-10314552;
CC Q4KMG9; B2RUZ4: SMIM1; NbExp=3; IntAct=EBI-18178701, EBI-12188413;
CC Q4KMG9; P02787: TF; NbExp=3; IntAct=EBI-18178701, EBI-714319;
CC Q4KMG9; Q9NV29: TMEM100; NbExp=3; IntAct=EBI-18178701, EBI-8644968;
CC Q4KMG9; Q6UX40: TMEM107; NbExp=3; IntAct=EBI-18178701, EBI-12845616;
CC Q4KMG9; Q9BVC6: TMEM109; NbExp=3; IntAct=EBI-18178701, EBI-1057733;
CC Q4KMG9; Q5BJH2-2: TMEM128; NbExp=3; IntAct=EBI-18178701, EBI-10694905;
CC Q4KMG9; Q9BVK8: TMEM147; NbExp=3; IntAct=EBI-18178701, EBI-348587;
CC Q4KMG9; Q9P0S9: TMEM14C; NbExp=3; IntAct=EBI-18178701, EBI-2339195;
CC Q4KMG9; Q969S6: TMEM203; NbExp=3; IntAct=EBI-18178701, EBI-12274070;
CC Q4KMG9; A2RU14: TMEM218; NbExp=3; IntAct=EBI-18178701, EBI-10173151;
CC Q4KMG9; Q0VDI3: TMEM267; NbExp=3; IntAct=EBI-18178701, EBI-17555467;
CC Q4KMG9; P56557: TMEM50B; NbExp=3; IntAct=EBI-18178701, EBI-12366453;
CC Q4KMG9; Q969K7: TMEM54; NbExp=3; IntAct=EBI-18178701, EBI-3922833;
CC Q4KMG9; Q9H2L4: TMEM60; NbExp=3; IntAct=EBI-18178701, EBI-2852148;
CC Q4KMG9; Q8N661: TMEM86B; NbExp=3; IntAct=EBI-18178701, EBI-2548832;
CC Q4KMG9; Q5BJF2: TMEM97; NbExp=3; IntAct=EBI-18178701, EBI-12111910;
CC Q4KMG9; Q71RG4: TMUB2; NbExp=3; IntAct=EBI-18178701, EBI-2820477;
CC Q4KMG9; Q8N609: TRAM1L1; NbExp=3; IntAct=EBI-18178701, EBI-11996766;
CC Q4KMG9; Q5BVD1: TTMP; NbExp=3; IntAct=EBI-18178701, EBI-10243654;
CC Q4KMG9; A5PKU2: TUSC5; NbExp=3; IntAct=EBI-18178701, EBI-11988865;
CC Q4KMG9; Q15836: VAMP3; NbExp=3; IntAct=EBI-18178701, EBI-722343;
CC Q4KMG9; O95183: VAMP5; NbExp=3; IntAct=EBI-18178701, EBI-10191195;
CC Q4KMG9; Q96MV8: ZDHHC15; NbExp=3; IntAct=EBI-18178701, EBI-12837904;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q4KMG9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q4KMG9-2; Sequence=VSP_026640;
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DR EMBL; AY358845; AAQ89204.1; -; mRNA.
DR EMBL; AK055728; BAB70998.1; -; mRNA.
DR EMBL; AC115676; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC098571; AAH98571.1; -; mRNA.
DR EMBL; BC131523; AAI31524.1; -; mRNA.
DR CCDS; CCDS66314.1; -. [Q4KMG9-1]
DR CCDS; CCDS8619.1; -. [Q4KMG9-2]
DR RefSeq; NP_001073283.1; NM_001079815.1. [Q4KMG9-1]
DR RefSeq; NP_694567.1; NM_153022.3. [Q4KMG9-2]
DR RefSeq; XP_006719092.1; XM_006719029.2.
DR AlphaFoldDB; Q4KMG9; -.
DR BioGRID; 125702; 115.
DR IntAct; Q4KMG9; 93.
DR STRING; 9606.ENSP00000371348; -.
DR iPTMnet; Q4KMG9; -.
DR PhosphoSitePlus; Q4KMG9; -.
DR BioMuta; TMEM52B; -.
DR DMDM; 121944266; -.
DR MassIVE; Q4KMG9; -.
DR PaxDb; Q4KMG9; -.
DR PeptideAtlas; Q4KMG9; -.
DR PRIDE; Q4KMG9; -.
DR Antibodypedia; 23262; 50 antibodies from 13 providers.
DR DNASU; 120939; -.
DR Ensembl; ENST00000298530.7; ENSP00000298530.3; ENSG00000165685.9. [Q4KMG9-2]
DR Ensembl; ENST00000381923.6; ENSP00000371348.2; ENSG00000165685.9. [Q4KMG9-1]
DR Ensembl; ENST00000543484.2; ENSP00000445582.2; ENSG00000165685.9. [Q4KMG9-1]
DR GeneID; 120939; -.
DR KEGG; hsa:120939; -.
DR MANE-Select; ENST00000543484.2; ENSP00000445582.2; NM_001384896.1; NP_001371825.1.
DR UCSC; uc001qxq.4; human. [Q4KMG9-1]
DR CTD; 120939; -.
DR DisGeNET; 120939; -.
DR GeneCards; TMEM52B; -.
DR HGNC; HGNC:26438; TMEM52B.
DR HPA; ENSG00000165685; Tissue enriched (kidney).
DR neXtProt; NX_Q4KMG9; -.
DR OpenTargets; ENSG00000165685; -.
DR PharmGKB; PA143485388; -.
DR VEuPathDB; HostDB:ENSG00000165685; -.
DR eggNOG; ENOG502S0XU; Eukaryota.
DR GeneTree; ENSGT00730000111328; -.
DR HOGENOM; CLU_100623_2_0_1; -.
DR InParanoid; Q4KMG9; -.
DR OMA; RLWYIWL; -.
DR OrthoDB; 1323580at2759; -.
DR PhylomeDB; Q4KMG9; -.
DR TreeFam; TF336037; -.
DR PathwayCommons; Q4KMG9; -.
DR SignaLink; Q4KMG9; -.
DR BioGRID-ORCS; 120939; 11 hits in 1066 CRISPR screens.
DR GenomeRNAi; 120939; -.
DR Pharos; Q4KMG9; Tdark.
DR PRO; PR:Q4KMG9; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q4KMG9; protein.
DR Bgee; ENSG00000165685; Expressed in kidney epithelium and 114 other tissues.
DR ExpressionAtlas; Q4KMG9; baseline and differential.
DR Genevisible; Q4KMG9; HS.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR038942; TMEM52.
DR PANTHER; PTHR33955; PTHR33955; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..183
FT /note="Transmembrane protein 52B"
FT /id="PRO_0000294448"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 158..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..33
FT /note="MGVRVHVVAASALLYFILLSGTRCEENCGNPEH -> MSWRPQPCCISSC
FT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12975309,
FT ECO:0000303|PubMed:14702039"
FT /id="VSP_026640"
SQ SEQUENCE 183 AA; 20002 MW; CF79A3C7EEDC2360 CRC64;
MGVRVHVVAA SALLYFILLS GTRCEENCGN PEHCLTTDWV HLWYIWLLVV IGALLLLCGL
TSLCFRCCCL SRQQNGEDGG PPPCEVTVIA FDHDSTLQST ITSLQSVFGP AARRILAVAH
SHSSLGQLPS SLDTLPGYEE ALHMSRFTVA MCGQKAPDLP PVPEEKQLPP TEKESTRIVD
SWN
