ID   TM59L_BOVIN             Reviewed;         349 AA.
AC   Q0VCT2;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Transmembrane protein 59-like;
DE   Flags: Precursor;
GN   Name=TMEM59L;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal cerebellum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Modulates the O-glycosylation and complex N-glycosylation
CC       steps occurring during the Golgi maturation of APP. Inhibits APP
CC       transport to the cell surface and further shedding (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-
CC       pass type I membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TMEM59 family. {ECO:0000305}.
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DR   EMBL; BC120018; AAI20019.1; -; mRNA.
DR   RefSeq; NP_001068769.1; NM_001075301.1.
DR   AlphaFoldDB; Q0VCT2; -.
DR   STRING; 9913.ENSBTAP00000010124; -.
DR   PaxDb; Q0VCT2; -.
DR   PRIDE; Q0VCT2; -.
DR   Ensembl; ENSBTAT00000010124; ENSBTAP00000010124; ENSBTAG00000007698.
DR   GeneID; 507157; -.
DR   KEGG; bta:507157; -.
DR   CTD; 25789; -.
DR   VEuPathDB; HostDB:ENSBTAG00000007698; -.
DR   VGNC; VGNC:36100; TMEM59L.
DR   eggNOG; ENOG502S08T; Eukaryota.
DR   GeneTree; ENSGT00390000008279; -.
DR   HOGENOM; CLU_059747_0_0_1; -.
DR   InParanoid; Q0VCT2; -.
DR   OMA; NAEEQFG; -.
DR   OrthoDB; 1102891at2759; -.
DR   TreeFam; TF331226; -.
DR   Proteomes; UP000009136; Chromosome 7.
DR   Bgee; ENSBTAG00000007698; Expressed in Ammon's horn and 91 other tissues.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; IEA:Ensembl.
DR   InterPro; IPR022065; Uncharacterised_TMEM59.
DR   PANTHER; PTHR28652; PTHR28652; 1.
DR   Pfam; PF12280; BSMAP; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Golgi apparatus; Membrane; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..349
FT                   /note="Transmembrane protein 59-like"
FT                   /id="PRO_0000282920"
FT   TRANSMEM        276..296
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOTIF           347..349
FT                   /note="Microbody targeting signal"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        100
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   349 AA;  38990 MW;  54E31C30E2689A37 CRC64;
     MDSVALMPLL LLLLLQPPPA TPAPPVRDPF ALQLGDTQNC QLRCRDRYPK PQLAQEELGE
     DPIQSRRAKA YDRAVLTSAC ERGCRLFSIC RFVARSSKPN ATQAECEAAC VEAYVKETEQ
     QACSEGCWSQ NPEPEPEPEL EQKRKVLEAP SGALSLLDLF STLCNDLVNS AQGFVSSTWT
     YYLQTDNGKV VVFQTQPVVE SLGHEGARLQ RVEVTWRGSH PEALEVHVDP VGPLDKVRKA
     KIRVKTSSKA KVESDELQDN DFLSCMSRRS GLPRWILACC LFLSVLVMLW LSCSTLVTAP
     GQHLKFQPLT LEQHKGYMVE PEWSLYPPPS HAYADSPPPY KLKLDLTKL