TM59L_HUMAN
ID TM59L_HUMAN Reviewed; 342 AA.
AC Q9UK28;
DT 26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Transmembrane protein 59-like;
DE AltName: Full=Brain-specific membrane-anchored protein;
DE Flags: Precursor;
GN Name=TMEM59L; Synonyms=BSMAP, C19orf4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10527841; DOI=10.1006/bbrc.1999.1481;
RA Elson G.C.A., Benoit de Coignac A., Aubry J.-P., Delneste Y.,
RA Magistrelli G., Holzwarth J., Bonnefoy J.-Y., Gauchat J.-F.;
RT "BSMAP, a novel protein expressed specifically in the brain whose gene is
RT localized on chromosome 19p12.";
RL Biochem. Biophys. Res. Commun. 264:55-62(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=20427278; DOI=10.1074/jbc.m109.055608;
RA Ullrich S., Munch A., Neumann S., Kremmer E., Tatzelt J.,
RA Lichtenthaler S.F.;
RT "The novel membrane protein TMEM59 modulates complex glycosylation, cell
RT surface expression, and secretion of the amyloid precursor protein.";
RL J. Biol. Chem. 285:20664-20674(2010).
CC -!- FUNCTION: Modulates the O-glycosylation and complex N-glycosylation
CC steps occurring during the Golgi maturation of APP. Inhibits APP
CC transport to the cell surface and further shedding.
CC {ECO:0000269|PubMed:20427278}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000305|PubMed:20427278}; Single-pass type I membrane protein
CC {ECO:0000305|PubMed:20427278}.
CC -!- TISSUE SPECIFICITY: Expressed preferentially at high level in the
CC brain.
CC -!- SIMILARITY: Belongs to the TMEM59 family. {ECO:0000305}.
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DR EMBL; AF186264; AAF00529.1; -; mRNA.
DR EMBL; BC010446; AAH10446.1; -; mRNA.
DR CCDS; CCDS12383.1; -.
DR PIR; JC7110; JC7110.
DR RefSeq; NP_036241.1; NM_012109.2.
DR AlphaFoldDB; Q9UK28; -.
DR BioGRID; 117322; 51.
DR IntAct; Q9UK28; 13.
DR STRING; 9606.ENSP00000470879; -.
DR TCDB; 8.A.84.1.1; the insulin secretion regulator tmem59 (tmem59) family.
DR GlyGen; Q9UK28; 1 site.
DR iPTMnet; Q9UK28; -.
DR PhosphoSitePlus; Q9UK28; -.
DR BioMuta; TMEM59L; -.
DR DMDM; 18203502; -.
DR EPD; Q9UK28; -.
DR MassIVE; Q9UK28; -.
DR PaxDb; Q9UK28; -.
DR PeptideAtlas; Q9UK28; -.
DR PRIDE; Q9UK28; -.
DR ProteomicsDB; 84711; -.
DR Antibodypedia; 2303; 114 antibodies from 23 providers.
DR DNASU; 25789; -.
DR Ensembl; ENST00000262817.8; ENSP00000262817.3; ENSG00000105696.9.
DR Ensembl; ENST00000600490.5; ENSP00000470879.1; ENSG00000105696.9.
DR GeneID; 25789; -.
DR KEGG; hsa:25789; -.
DR MANE-Select; ENST00000262817.8; ENSP00000262817.3; NM_012109.3; NP_036241.1.
DR UCSC; uc002njy.5; human.
DR CTD; 25789; -.
DR DisGeNET; 25789; -.
DR GeneCards; TMEM59L; -.
DR HGNC; HGNC:13237; TMEM59L.
DR HPA; ENSG00000105696; Group enriched (brain, pituitary gland).
DR neXtProt; NX_Q9UK28; -.
DR OpenTargets; ENSG00000105696; -.
DR PharmGKB; PA162406615; -.
DR VEuPathDB; HostDB:ENSG00000105696; -.
DR eggNOG; ENOG502S08T; Eukaryota.
DR GeneTree; ENSGT00390000008279; -.
DR HOGENOM; CLU_059747_0_0_1; -.
DR InParanoid; Q9UK28; -.
DR OMA; NAEEQFG; -.
DR OrthoDB; 1102891at2759; -.
DR PhylomeDB; Q9UK28; -.
DR TreeFam; TF331226; -.
DR PathwayCommons; Q9UK28; -.
DR SignaLink; Q9UK28; -.
DR BioGRID-ORCS; 25789; 9 hits in 1066 CRISPR screens.
DR ChiTaRS; TMEM59L; human.
DR GenomeRNAi; 25789; -.
DR Pharos; Q9UK28; Tbio.
DR PRO; PR:Q9UK28; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q9UK28; protein.
DR Bgee; ENSG00000105696; Expressed in right hemisphere of cerebellum and 125 other tissues.
DR ExpressionAtlas; Q9UK28; baseline and differential.
DR Genevisible; Q9UK28; HS.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; TAS:ProtInc.
DR GO; GO:0016020; C:membrane; TAS:ProtInc.
DR GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; IEA:Ensembl.
DR InterPro; IPR022065; Uncharacterised_TMEM59.
DR PANTHER; PTHR28652; PTHR28652; 1.
DR Pfam; PF12280; BSMAP; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Golgi apparatus; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..342
FT /note="Transmembrane protein 59-like"
FT /id="PRO_0000003000"
FT TRANSMEM 268..290
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOTIF 340..342
FT /note="Microbody targeting signal"
FT /evidence="ECO:0000255"
FT CARBOHYD 97
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 342 AA; 37619 MW; FB56B6B37AF62569 CRC64;
MAAVALMPPP LLLLLLLASP PAASAPSARD PFAPQLGDTQ NCQLRCRDRD LGPQPSQAGL
EGASESPYDR AVLISACERG CRLFSICRFV ARSSKPNATQ TECEAACVEA YVKEAEQQAC
SHGCWSQPAE PEPEQKRKVL EAPSGALSLL DLFSTLCNDL VNSAQGFVSS TWTYYLQTDN
GKVVVFQTQP IVESLGFQGG RLQRVEVTWR GSHPEALEVH VDPVGPLDKV RKAKIRVKTS
SKAKVESEEP QDNDFLSCMS RRSGLPRWIL ACCLFLSVLV MLWLSCSTLV TAPGQHLKFQ
PLTLEQHKGF MMEPDWPLYP PPSHACEDSL PPYKLKLDLT KL
