ID   TM59L_MOUSE             Reviewed;         337 AA.
AC   Q7TNI2;
DT   07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Transmembrane protein 59-like;
DE   AltName: Full=Brain-specific membrane-anchored protein;
DE   Flags: Precursor;
GN   Name=Tmem59l; Synonyms=Bsmap;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Modulates the O-glycosylation and complex N-glycosylation
CC       steps occurring during the Golgi maturation of APP. Inhibits APP
CC       transport to the cell surface and further shedding (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-
CC       pass type I membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TMEM59 family. {ECO:0000305}.
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DR   EMBL; BC056172; AAH56172.1; -; mRNA.
DR   CCDS; CCDS22368.1; -.
DR   RefSeq; NP_892036.1; NM_182991.2.
DR   AlphaFoldDB; Q7TNI2; -.
DR   SMR; Q7TNI2; -.
DR   STRING; 10090.ENSMUSP00000043659; -.
DR   GlyGen; Q7TNI2; 1 site.
DR   iPTMnet; Q7TNI2; -.
DR   PhosphoSitePlus; Q7TNI2; -.
DR   MaxQB; Q7TNI2; -.
DR   PaxDb; Q7TNI2; -.
DR   PRIDE; Q7TNI2; -.
DR   ProteomicsDB; 259116; -.
DR   Antibodypedia; 2303; 114 antibodies from 23 providers.
DR   DNASU; 67937; -.
DR   Ensembl; ENSMUST00000045286; ENSMUSP00000043659; ENSMUSG00000035964.
DR   GeneID; 67937; -.
DR   KEGG; mmu:67937; -.
DR   UCSC; uc009mai.2; mouse.
DR   CTD; 25789; -.
DR   MGI; MGI:1915187; Tmem59l.
DR   VEuPathDB; HostDB:ENSMUSG00000035964; -.
DR   eggNOG; ENOG502S08T; Eukaryota.
DR   GeneTree; ENSGT00390000008279; -.
DR   HOGENOM; CLU_059747_0_0_1; -.
DR   InParanoid; Q7TNI2; -.
DR   OMA; NAEEQFG; -.
DR   OrthoDB; 1102891at2759; -.
DR   PhylomeDB; Q7TNI2; -.
DR   TreeFam; TF331226; -.
DR   BioGRID-ORCS; 67937; 2 hits in 74 CRISPR screens.
DR   PRO; PR:Q7TNI2; -.
DR   Proteomes; UP000000589; Chromosome 8.
DR   RNAct; Q7TNI2; protein.
DR   Bgee; ENSMUSG00000035964; Expressed in cerebellar cortex and 141 other tissues.
DR   Genevisible; Q7TNI2; MM.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; IMP:MGI.
DR   InterPro; IPR022065; Uncharacterised_TMEM59.
DR   PANTHER; PTHR28652; PTHR28652; 1.
DR   Pfam; PF12280; BSMAP; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Golgi apparatus; Membrane; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..337
FT                   /note="Transmembrane protein 59-like"
FT                   /id="PRO_0000003001"
FT   TRANSMEM        263..283
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          36..62
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           335..337
FT                   /note="Microbody targeting signal"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        90
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   337 AA;  37661 MW;  F58B93B072453E3A CRC64;
     MAAVALPLLL LLASLVTPTP ARDPFAPQLG DTQRCQQRCR QHHPGSPPAQ PEPEGPSESP
     NNKAILISAC ERGCRLFSIC RFVAKSSRPN ATETECEAAC TEAYVKAAEQ RACSEGCWGQ
     IPEPETQLEQ KDLALDPPRG RLSLRYLFSM LCSDLMSSAQ GFLSSSWTYS LQTDNRKVVV
     FQTQPVAENF AFQGSHLQRV EVTWRRSHPK ALELHMDPVG PLDKVRKAKP RVKTSKAKVE
     SEDQQESDFL SCMSRRSGLP RWVLFCCLFL SILIMLWLSC CTLVTTPGQH LKFQPLTAEQ
     HKGLLVESDW PLYPPLPPPA YEDSTPPYKL KLDLTTL