ID   TM59L_RAT               Reviewed;         331 AA.
AC   Q5HZE8;
DT   07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2005, sequence version 2.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Transmembrane protein 59-like;
DE   AltName: Full=Brain-specific membrane-anchored protein;
DE   Flags: Precursor;
GN   Name=Tmem59l; Synonyms=Bsmap;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-331.
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Modulates the O-glycosylation and complex N-glycosylation
CC       steps occurring during the Golgi maturation of APP. Inhibits APP
CC       transport to the cell surface and further shedding (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-
CC       pass type I membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TMEM59 family. {ECO:0000305}.
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DR   EMBL; BC089056; AAH89056.1; -; mRNA.
DR   AlphaFoldDB; Q5HZE8; -.
DR   SMR; Q5HZE8; -.
DR   STRING; 10116.ENSRNOP00000029378; -.
DR   GlyGen; Q5HZE8; 1 site.
DR   PaxDb; Q5HZE8; -.
DR   PRIDE; Q5HZE8; -.
DR   UCSC; RGD:1305557; rat.
DR   RGD; 1305557; Tmem59l.
DR   eggNOG; ENOG502S08T; Eukaryota.
DR   InParanoid; Q5HZE8; -.
DR   PhylomeDB; Q5HZE8; -.
DR   TreeFam; TF331226; -.
DR   PRO; PR:Q5HZE8; -.
DR   Proteomes; UP000002494; Unplaced.
DR   Genevisible; Q5HZE8; RN.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; ISO:RGD.
DR   InterPro; IPR022065; Uncharacterised_TMEM59.
DR   PANTHER; PTHR28652; PTHR28652; 1.
DR   Pfam; PF12280; BSMAP; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Golgi apparatus; Membrane; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..331
FT                   /note="Transmembrane protein 59-like"
FT                   /id="PRO_0000003002"
FT   TRANSMEM        258..278
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          15..62
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           329..331
FT                   /note="Microbody targeting signal"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        90
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   331 AA;  36976 MW;  7F7D413CBE0A5005 CRC64;
     MAAVALPLLL LLASPATPTP ARDPFSPQLG DTQRCQQRCR QRHPGLPPAQ PEPEGPSESP
     NNKAVLINAC ERGCRLFSIC RFVARSSRPN ATETECEAAC TEAYVKAKEQ QACSEGCWGQ
     IPEPETQLEQ KELALDPPSG SLSLRHLFTM LCSDLMSSAQ DLISSTWTYS LQTDNRKTQP
     VVENFAFQGS RLQRVEVTWR GSHPKALEVH MDPMSPLEKV RRAKPHLKTS KAKVESEDQQ
     ESDFLSCMSR RSGLPRWVLF CCLFLSVLII LWLSCCTLVT TPGQHLKFQP LTAEQHKGLL
     VESNWPLYPP LPPAYEDSPP PYKLKLDLTT L