ID   TM6S1_BOVIN             Reviewed;         370 AA.
AC   A6QL84;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Transmembrane 6 superfamily member 1;
GN   Name=TM6SF1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Heart ventricle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May function as sterol isomerase.
CC       {ECO:0000250|UniProtKB:Q9BZW5}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:P58749};
CC       Multi-pass membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TM6SF family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC147874; AAI47875.1; -; mRNA.
DR   RefSeq; NP_001095765.1; NM_001102295.2.
DR   AlphaFoldDB; A6QL84; -.
DR   STRING; 9913.ENSBTAP00000017175; -.
DR   PaxDb; A6QL84; -.
DR   GeneID; 616003; -.
DR   KEGG; bta:616003; -.
DR   CTD; 53346; -.
DR   eggNOG; ENOG502QRB2; Eukaryota.
DR   InParanoid; A6QL84; -.
DR   OrthoDB; 784438at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; ISS:UniProtKB.
DR   InterPro; IPR033118; EXPERA.
DR   PROSITE; PS51751; EXPERA; 2.
PE   2: Evidence at transcript level;
KW   Lysosome; Membrane; Reference proteome; Repeat; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..370
FT                   /note="Transmembrane 6 superfamily member 1"
FT                   /id="PRO_0000366932"
FT   TRANSMEM        3..23
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        34..54
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        62..82
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        110..130
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..159
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        166..186
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        218..238
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        268..288
FT                   /note="Helical; Name=8"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        331..351
FT                   /note="Helical; Name=9"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          60..185
FT                   /note="EXPERA 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01087"
FT   DOMAIN          216..350
FT                   /note="EXPERA 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01087"
SQ   SEQUENCE   370 AA;  41651 MW;  1D9FB987718F6E45 CRC64;
     MSASAATGVF VLSLSAIPVT YVFNHLAAQH DSWTIVGAAA VVLLLVALLA RVLVKRKPPR
     DPLFYVYAVF GFTSVVNRII GLEQDGIIDG FMTHYLREGE PYLNTAYGHM ICYWDGSAHY
     LMYLVMVAAI AWEESYRTIG LYWVGSIIMS IVVFVPGNIV GKYGTRICPA FFLSIPYTCL
     PVWAGFRIYN QPSENYNYPS KVIQEVQAKD LLRRPFDLIL VLCLLLATGF CVFRGLIALD
     CPAELCRLYT QFQEPYLKDP AAYPKIQMLA YLFYSVPYFV IALYGLVVPG CFWMPDITLI
     HAGGLAQAQF SHIGASLHAR TAYVYRVPEE AKIIFLALNI AYGVLPQLLA YRCIYRPEFF
     IKTKADEKVE