TM6S1_MOUSE
ID TM6S1_MOUSE Reviewed; 370 AA.
AC P58749; Q8BUN7;
DT 27-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Transmembrane 6 superfamily member 1;
GN Name=Tm6sf1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Hippocampus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RX PubMed=25422095; DOI=10.1007/s00709-014-0733-x;
RA Tam W.Y., Jiang L., Kwan K.M.;
RT "Transmembrane 6 superfamily 1 (Tm6sf1) is a novel lysosomal transmembrane
RT protein.";
RL Protoplasma 252:977-983(2015).
CC -!- FUNCTION: May function as sterol isomerase.
CC {ECO:0000250|UniProtKB:Q9BZW5}.
CC -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:25422095};
CC Multi-pass membrane protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Broad expression. {ECO:0000269|PubMed:25422095}.
CC -!- SIMILARITY: Belongs to the TM6SF family. {ECO:0000305}.
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DR EMBL; AK083132; BAC38776.1; -; mRNA.
DR EMBL; BC023123; AAH23123.1; -; mRNA.
DR CCDS; CCDS21408.1; -.
DR RefSeq; NP_001278211.1; NM_001291282.1.
DR RefSeq; NP_663350.2; NM_145375.4.
DR AlphaFoldDB; P58749; -.
DR STRING; 10090.ENSMUSP00000038017; -.
DR PhosphoSitePlus; P58749; -.
DR MaxQB; P58749; -.
DR PaxDb; P58749; -.
DR PRIDE; P58749; -.
DR ProteomicsDB; 259564; -.
DR Antibodypedia; 15402; 78 antibodies from 14 providers.
DR DNASU; 107769; -.
DR Ensembl; ENSMUST00000041890; ENSMUSP00000038017; ENSMUSG00000038623.
DR GeneID; 107769; -.
DR KEGG; mmu:107769; -.
DR UCSC; uc009ico.3; mouse.
DR CTD; 53346; -.
DR MGI; MGI:1933209; Tm6sf1.
DR VEuPathDB; HostDB:ENSMUSG00000038623; -.
DR eggNOG; ENOG502QRB2; Eukaryota.
DR GeneTree; ENSGT00390000012913; -.
DR InParanoid; P58749; -.
DR OMA; FFMKPKQ; -.
DR OrthoDB; 784438at2759; -.
DR PhylomeDB; P58749; -.
DR TreeFam; TF333088; -.
DR BioGRID-ORCS; 107769; 0 hits in 73 CRISPR screens.
DR ChiTaRS; Tm6sf1; mouse.
DR PRO; PR:P58749; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; P58749; protein.
DR Bgee; ENSMUSG00000038623; Expressed in granulocyte and 226 other tissues.
DR ExpressionAtlas; P58749; baseline and differential.
DR Genevisible; P58749; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005765; C:lysosomal membrane; IDA:UniProtKB.
DR InterPro; IPR033118; EXPERA.
DR PROSITE; PS51751; EXPERA; 2.
PE 2: Evidence at transcript level;
KW Lysosome; Membrane; Reference proteome; Repeat; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..370
FT /note="Transmembrane 6 superfamily member 1"
FT /id="PRO_0000181834"
FT TRANSMEM 3..23
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 34..54
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 166..186
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 218..238
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TRANSMEM 268..288
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TRANSMEM 331..351
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT DOMAIN 60..185
FT /note="EXPERA 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01087"
FT DOMAIN 216..350
FT /note="EXPERA 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01087"
FT CONFLICT 222
FT /note="L -> V (in Ref. 2; AAH23123)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 370 AA; 41662 MW; FE95FA802C386DA2 CRC64;
MSASAATGVF VLSLSAIPVT YIFNHLAAQH DSWTIVGVAA LILLLVALLA RVLVRRKPPR
DPLFYVYAVF GFTSVVNLII GLEQDGIIDG FMTHYLREGE PYLNTAYGHM ICYWDGSVHY
LMYLVMVAAI AWEESYRTIG LYWVGSIIMS IVVFVPGNIV GKYGTRICPA FFLSIPYTCL
PVWAGFRIYN QPSENYNYPS KVLQEAQAKA LLRRPFDLVL VLCLFLATGF CLFRGLIALD
CPAELCRLYT QFQEPYLKDP AAYPKIQMLA YMFYSVPYFV IALYGLVVPG CSWMPDITLV
HAGGLAQAQF SHIGASLHAR TAYVYRVPEE AKIFFLALNI AYGVLPQLLA YRCTYNPEFF
LRTKADEKLE
