ID   TM6S1_PONAB             Reviewed;         370 AA.
AC   Q5RBJ7;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=Transmembrane 6 superfamily member 1;
GN   Name=TM6SF1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May function as sterol isomerase.
CC       {ECO:0000250|UniProtKB:Q9BZW5}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:P58749};
CC       Multi-pass membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TM6SF family. {ECO:0000305}.
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DR   EMBL; CR858648; CAH90863.1; -; mRNA.
DR   RefSeq; NP_001125493.1; NM_001132021.1.
DR   AlphaFoldDB; Q5RBJ7; -.
DR   STRING; 9601.ENSPPYP00000007646; -.
DR   GeneID; 100172402; -.
DR   KEGG; pon:100172402; -.
DR   CTD; 53346; -.
DR   eggNOG; ENOG502QRB2; Eukaryota.
DR   InParanoid; Q5RBJ7; -.
DR   OrthoDB; 784438at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; ISS:UniProtKB.
DR   InterPro; IPR033118; EXPERA.
DR   PROSITE; PS51751; EXPERA; 2.
PE   2: Evidence at transcript level;
KW   Lysosome; Membrane; Reference proteome; Repeat; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..370
FT                   /note="Transmembrane 6 superfamily member 1"
FT                   /id="PRO_0000366933"
FT   TRANSMEM        3..23
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        34..54
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        62..82
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        110..130
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..159
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        166..186
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        218..238
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        268..288
FT                   /note="Helical; Name=8"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        331..351
FT                   /note="Helical; Name=9"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          60..185
FT                   /note="EXPERA 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01087"
FT   DOMAIN          216..350
FT                   /note="EXPERA 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01087"
SQ   SEQUENCE   370 AA;  41664 MW;  DDC80D2AA50F6388 CRC64;
     MSASAATGVF VLSLSAIPVT YVFNHLAAQH DSWTIVGVAA LILFLVALLA RVLVKRKPPR
     DPLFYVYAVF GFTSVVNLII GLEQDGIIDG FMTHYLREGE PYLNTAYGHM ICYWDGSAHY
     LMYLVMVAAI AWEETYRTIG LYWVGSIIMS VVVFVPGNIV GKYGTRICPA FFLSIPYTCL
     PVWAGFRIYN QPSENYNYPS KVIQEAQAKD LLRRPFDLML VVCLLLATGF CLFRGLIALD
     CPSELCRLYT QFQEPYLKDP AAYPKIQMLV YMFYSVPYFV TALYGLVVPG CSWMPDITLI
     HAGGLAQAQF SHIGASLHAR TAYVYRVPEE AKILFLALNI AYGVLPQLLA YRCIYKPEFF
     IKTKAEEKVE