ID   TM6S1_XENLA             Reviewed;         370 AA.
AC   Q6DCP8;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 52.
DE   RecName: Full=Transmembrane 6 superfamily member 1;
GN   Name=tm6sf1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May function as sterol isomerase.
CC       {ECO:0000250|UniProtKB:Q9BZW5}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:P58749};
CC       Multi-pass membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TM6SF family. {ECO:0000305}.
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DR   EMBL; BC077954; AAH77954.1; -; mRNA.
DR   RefSeq; NP_001087056.1; NM_001093587.1.
DR   AlphaFoldDB; Q6DCP8; -.
DR   DNASU; 446891; -.
DR   GeneID; 446891; -.
DR   KEGG; xla:446891; -.
DR   CTD; 446891; -.
DR   Xenbase; XB-GENE-958250; tm6sf1.L.
DR   OMA; VAIAWDQ; -.
DR   OrthoDB; 784438at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 446891; Expressed in heart and 10 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; ISS:UniProtKB.
DR   InterPro; IPR033118; EXPERA.
DR   PROSITE; PS51751; EXPERA; 2.
PE   2: Evidence at transcript level;
KW   Lysosome; Membrane; Reference proteome; Repeat; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..370
FT                   /note="Transmembrane 6 superfamily member 1"
FT                   /id="PRO_0000366934"
FT   TRANSMEM        9..29
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        35..55
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        62..82
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        110..130
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..159
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        167..187
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        218..238
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        268..288
FT                   /note="Helical; Name=8"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        297..317
FT                   /note="Helical; Name=9"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        331..351
FT                   /note="Helical; Name=10"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          60..185
FT                   /note="EXPERA 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01087"
FT   DOMAIN          216..350
FT                   /note="EXPERA 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01087"
SQ   SEQUENCE   370 AA;  41365 MW;  F08A3A28523900F7 CRC64;
     MSAPAATGVF ILSLTAIPTT YIFNFYFAVN SSWPVAAGGA GILLLTAILA RLLVIQKPPK
     DSLFYVYAVF AFTSVIGLII GLEQDGIIDG FMTHYLKESE PYLNTAYGHM ICYWDGTAHY
     LMYLLMVVAI AWDQTYRTIG LYWVGSILMS TIVFIPGNIV GKYGTRICSA LLLNLPYLCL
     PLWAGYKIYK QPSDIPILSS KAIQNIQHKS IFRRPSDLFL ALYLILAIIF CIFRGMIALD
     CPADPCRFYI QLQEPYIKDP SAYPKLQMLV LMFYCVPNNL ILLYGLLVPG CTWMPDLSLI
     SAGGIAQAQF SHIGASLHAR TPYIYRVPDE ARIFFFTANI LFGLGSQLLA HRCVNKPEFF
     QKAKSGMKAE