BT2A3_HUMAN
ID BT2A3_HUMAN Reviewed; 586 AA.
AC Q96KV6; A6NEF4;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 10-JUL-2007, sequence version 2.
DT 25-MAY-2022, entry version 134.
DE RecName: Full=Putative butyrophilin subfamily 2 member A3;
DE Flags: Precursor;
GN Name=BTN2A3P; Synonyms=BTN2A3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. BTN/MOG family.
CC {ECO:0000305}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR EMBL; AL021917; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471087; EAW55569.1; -; Genomic_DNA.
DR AlphaFoldDB; Q96KV6; -.
DR SMR; Q96KV6; -.
DR IntAct; Q96KV6; 1.
DR MINT; Q96KV6; -.
DR GlyGen; Q96KV6; 4 sites.
DR iPTMnet; Q96KV6; -.
DR PhosphoSitePlus; Q96KV6; -.
DR BioMuta; HGNC:13229; -.
DR DMDM; 152031567; -.
DR jPOST; Q96KV6; -.
DR MassIVE; Q96KV6; -.
DR PeptideAtlas; Q96KV6; -.
DR PRIDE; Q96KV6; -.
DR ProteomicsDB; 77119; -.
DR GeneCards; BTN2A3P; -.
DR HGNC; HGNC:13229; BTN2A3P.
DR MIM; 613592; gene.
DR neXtProt; NX_Q96KV6; -.
DR InParanoid; Q96KV6; -.
DR PhylomeDB; Q96KV6; -.
DR PathwayCommons; Q96KV6; -.
DR Pharos; Q96KV6; Tdark.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q96KV6; protein.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR GO; GO:0001817; P:regulation of cytokine production; IBA:GO_Central.
DR GO; GO:0050852; P:T cell receptor signaling pathway; IBA:GO_Central.
DR CDD; cd15819; SPRY_PRY_BTN1_2; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR037958; SPRY/PRY_BTN1/2.
DR InterPro; IPR003877; SPRY_dom.
DR Pfam; PF13765; PRY; 1.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF07686; V-set; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00409; IG; 1.
DR SMART; SM00406; IGv; 1.
DR SMART; SM00589; PRY; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF48726; SSF48726; 2.
DR SUPFAM; SSF49899; SSF49899; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 5: Uncertain;
KW Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..586
FT /note="Putative butyrophilin subfamily 2 member A3"
FT /id="PRO_0000014531"
FT TOPO_DOM 28..246
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 247..267
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 268..586
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 28..139
FT /note="Ig-like V-type"
FT DOMAIN 281..474
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
FT CARBOHYD 45
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 112
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 214
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 220
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 50..123
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VARIANT 79
FT /note="G -> D (in dbSNP:rs7745238)"
FT /id="VAR_049830"
FT VARIANT 148
FT /note="V -> I (in dbSNP:rs10946829)"
FT /id="VAR_049831"
FT VARIANT 300
FT /note="N -> S (in dbSNP:rs2893848)"
FT /id="VAR_049832"
SQ SEQUENCE 586 AA; 65713 MW; E320F80CAD074448 CRC64;
MEPAAALHFS RPASLLLLLS LCALVSAQVT VVGPTDPILA MVGENTTLRC CLSPEENAED
MEVRWFQSQF SPAVFVYKGG RERTEEQKEE YRGRTTFVSK DSRGSVALII HNVTAEDNGI
YQCYFQEGRS CNEAILHLVV AGLDSEPVIE MRDHEDGGIQ LECISGGWYP KPLTVWRDPY
GEVVPALKEV STPDADSLFM VTTAVIIRDK SVRNVSCSIN DTLLGQKKES VIFIPESFMP
SRSPCVVILP VIMIILMIPI AICIYWINNL QKEKKDSHLM TFNLCLSLAG WRRTFLHAAN
VVLDQDTGHP YLFVSEDKRS VTLDPSRESI PGNPERFDSQ LCVLGQESFA SGKHYLEVDV
ENVIEWTVGI CRDNVERKWE VPLLPQNGFW TLEMHKRKYW ALTSLKWILS LEEPLCQVGI
FLDYEAGDVS FYNMRDRSHI YTFPHSAFSV PVRPFFSLGS YDSQILICSA FTGASGVTVP
EEGWTLHRAG THHSPQNQFP SLTAMETSPG HLSSHCTMPL VEDTPSSPLV TQENIFQLPL
SHPLQTSAPV HLLIRCGFSS SFGCNYGMES RHRELVVPQL PARKKV
