ID   TM6S1_XENTR             Reviewed;         370 AA.
AC   Q0V982; B1H1C1;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Transmembrane 6 superfamily member 1;
GN   Name=tm6sf1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=N6; TISSUE=Heart, and Oviduct;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May function as sterol isomerase.
CC       {ECO:0000250|UniProtKB:Q9BZW5}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:P58749};
CC       Multi-pass membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TM6SF family. {ECO:0000305}.
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DR   EMBL; BC121709; AAI21710.1; -; mRNA.
DR   EMBL; BC160549; AAI60549.1; -; mRNA.
DR   RefSeq; NP_001072826.1; NM_001079358.1.
DR   AlphaFoldDB; Q0V982; -.
DR   STRING; 8364.ENSXETP00000053849; -.
DR   PaxDb; Q0V982; -.
DR   DNASU; 780287; -.
DR   GeneID; 780287; -.
DR   KEGG; xtr:780287; -.
DR   CTD; 53346; -.
DR   Xenbase; XB-GENE-958245; tm6sf1.
DR   eggNOG; ENOG502QRB2; Eukaryota.
DR   HOGENOM; CLU_046717_0_0_1; -.
DR   InParanoid; Q0V982; -.
DR   OrthoDB; 784438at2759; -.
DR   PhylomeDB; Q0V982; -.
DR   TreeFam; TF333088; -.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; ISS:UniProtKB.
DR   InterPro; IPR033118; EXPERA.
DR   PROSITE; PS51751; EXPERA; 2.
PE   2: Evidence at transcript level;
KW   Lysosome; Membrane; Reference proteome; Repeat; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..370
FT                   /note="Transmembrane 6 superfamily member 1"
FT                   /id="PRO_0000366935"
FT   TRANSMEM        9..29
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        35..55
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        62..82
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        110..130
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..159
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        168..188
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        218..238
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        268..288
FT                   /note="Helical; Name=8"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        331..351
FT                   /note="Helical; Name=9"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          60..185
FT                   /note="EXPERA 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01087"
FT   DOMAIN          216..350
FT                   /note="EXPERA 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01087"
FT   CONFLICT        198
FT                   /note="Y -> H (in Ref. 1; AAI60549)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   370 AA;  41530 MW;  507431CB21649176 CRC64;
     MSAPAATGVF ILSLTAIPAT YTFNFFFAFN SSWPVAAGGA GILLVIAILA RLLVIQKPPK
     DPLFYVYAVF AFTSVIGLII GLEQDGIIDG FMTHYLKESE PYLNTAYGHM ICYWDGTAHY
     LMYLLMVVAI AWDQNYRTIG LYWVGSILMS TIVFIPGNIV GKYGTRVCSA LLLNLPYLCL
     PLWAGFKIYK QPSVTPNYSS KEIQNIQHKS IYRRPSDLLL ALYLILATLF CIFRGMIALD
     CPADPCRFYI QLQEPYIKDP SAYPRLQMLV LMFYCVPYNL ILLYGLLVPE CTWMPDLSLI
     SAGGIAQAQF SHIGASLHAR TPYIYRVPDE ARIFFFTANI LYGLGSQLLA HRCVNKPEFF
     LKAKSGAKDK