ID   TM6S2_RAT               Reviewed;         378 AA.
AC   B0BNG2;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Transmembrane 6 superfamily member 2;
GN   Name=Tm6sf2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Regulator of liver fat metabolism influencing triglyceride
CC       secretion and hepatic lipid droplet content. May function as sterol
CC       isomerase. {ECO:0000250|UniProtKB:Q9BZW4}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q9BZW4}; Multi-pass membrane protein
CC       {ECO:0000255}. Endoplasmic reticulum-Golgi intermediate compartment
CC       membrane {ECO:0000250|UniProtKB:Q9BZW4}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the TM6SF family. {ECO:0000305}.
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DR   EMBL; CH474031; EDL90645.1; -; Genomic_DNA.
DR   EMBL; BC158807; AAI58808.1; -; mRNA.
DR   RefSeq; NP_001121126.1; NM_001127654.1.
DR   AlphaFoldDB; B0BNG2; -.
DR   STRING; 10116.ENSRNOP00000027800; -.
DR   PaxDb; B0BNG2; -.
DR   PeptideAtlas; B0BNG2; -.
DR   Ensembl; ENSRNOT00000027800; ENSRNOP00000027800; ENSRNOG00000042237.
DR   GeneID; 689029; -.
DR   KEGG; rno:689029; -.
DR   UCSC; RGD:1597457; rat.
DR   CTD; 53345; -.
DR   RGD; 1597457; Tm6sf2.
DR   eggNOG; ENOG502QRB2; Eukaryota.
DR   GeneTree; ENSGT00390000012913; -.
DR   HOGENOM; CLU_046717_0_0_1; -.
DR   InParanoid; B0BNG2; -.
DR   OMA; TDSCFVY; -.
DR   OrthoDB; 784438at2759; -.
DR   PhylomeDB; B0BNG2; -.
DR   TreeFam; TF333088; -.
DR   PRO; PR:B0BNG2; -.
DR   Proteomes; UP000002494; Chromosome 16.
DR   Proteomes; UP000234681; Chromosome 16.
DR   Bgee; ENSRNOG00000042237; Expressed in jejunum and 18 other tissues.
DR   Genevisible; B0BNG2; RN.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR   GO; GO:0055088; P:lipid homeostasis; IBA:GO_Central.
DR   GO; GO:0019216; P:regulation of lipid metabolic process; ISS:UniProtKB.
DR   InterPro; IPR033118; EXPERA.
DR   PROSITE; PS51751; EXPERA; 2.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Repeat; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..378
FT                   /note="Transmembrane 6 superfamily member 2"
FT                   /id="PRO_0000402385"
FT   TRANSMEM        34..54
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        63..83
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        110..130
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..160
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        170..190
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        219..239
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        269..289
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        291..311
FT                   /note="Helical; Name=8"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        332..352
FT                   /note="Helical; Name=9"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          61..186
FT                   /note="EXPERA 1"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BZW4"
FT   DOMAIN          217..351
FT                   /note="EXPERA 2"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BZW4"
SQ   SEQUENCE   378 AA;  42574 MW;  36629222DF22304C CRC64;
     MDIPPLAGRT VAMSLGALPV SYVLNQVSAF SQPLCVVLTS ALVLGLLFMA VYSLSHGEIT
     YDPLYAVFVV FSFTSVVDLV IALQEDGYLM GLMDFYAKEG EPYLRTAHGI FICYWDGTVH
     YLLYLTMAGA IRKRKRYRNL GLYWLGSFAM SLLVFLPGNI LGKYSSEIRP TFFLAILYML
     VPCWAGMRIF NQSPAPSSCT CDVVQEEQKK SLLQRPADLT LIVYLILAAF FTVFRGLVVL
     DCPADACFIY IYQYEPYLRD PVAYPKLQML MYLFYALPFY CLAAYALTFP GCSWLPDWAL
     VFAGAIGQAQ FSHMGASMHL RTPFTYRVPE DTWATFLLSN LLFALGPHLL ALRCLWRPAF
     FLRAAPPSSP QDQGKKQQ