ID   TM6_VITVI               Reviewed;         225 AA.
AC   Q003J2; F6GWR1;
DT   05-JUN-2019, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Agamous-like MADS-box protein TM6 {ECO:0000305};
DE   AltName: Full=VvAP3.2 {ECO:0000303|PubMed:18997115};
DE   AltName: Full=VviAP3b {ECO:0000303|PubMed:26818751};
GN   Name=TM6 {ECO:0000303|PubMed:17920788};
GN   OrderedLocusNames=VIT_04s0023g02820 {ECO:0000312|EMBL:CCB44396.1};
GN   ORFNames=VITISV_019954 {ECO:0000312|EMBL:CAN66176.1};
OS   Vitis vinifera (Grape).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; Vitales; Vitaceae; Viteae; Vitis.
OX   NCBI_TaxID=29760;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=17920788; DOI=10.1016/j.gene.2007.08.005;
RA   Poupin M.J., Federici F., Medina C., Matus J.T., Timmermann T.,
RA   Arce-Johnson P.;
RT   "Isolation of the three grape sub-lineages of B-class MADS-box TM6,
RT   PISTILLATA and APETALA3 genes which are differentially expressed during
RT   flower and fruit development.";
RL   Gene 404:10-24(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Pinot noir / PN40024;
RX   PubMed=17721507; DOI=10.1038/nature06148;
RA   Jaillon O., Aury J.-M., Noel B., Policriti A., Clepet C., Casagrande A.,
RA   Choisne N., Aubourg S., Vitulo N., Jubin C., Vezzi A., Legeai F.,
RA   Hugueney P., Dasilva C., Horner D., Mica E., Jublot D., Poulain J.,
RA   Bruyere C., Billault A., Segurens B., Gouyvenoux M., Ugarte E.,
RA   Cattonaro F., Anthouard V., Vico V., Del Fabbro C., Alaux M.,
RA   Di Gaspero G., Dumas V., Felice N., Paillard S., Juman I., Moroldo M.,
RA   Scalabrin S., Canaguier A., Le Clainche I., Malacrida G., Durand E.,
RA   Pesole G., Laucou V., Chatelet P., Merdinoglu D., Delledonne M.,
RA   Pezzotti M., Lecharny A., Scarpelli C., Artiguenave F., Pe M.E., Valle G.,
RA   Morgante M., Caboche M., Adam-Blondon A.-F., Weissenbach J., Quetier F.,
RA   Wincker P.;
RT   "The grapevine genome sequence suggests ancestral hexaploidization in major
RT   angiosperm phyla.";
RL   Nature 449:463-467(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Pinot noir;
RX   PubMed=18094749; DOI=10.1371/journal.pone.0001326;
RA   Velasco R., Zharkikh A., Troggio M., Cartwright D.A., Cestaro A., Pruss D.,
RA   Pindo M., FitzGerald L.M., Vezzulli S., Reid J., Malacarne G., Iliev D.,
RA   Coppola G., Wardell B., Micheletti D., Macalma T., Facci M., Mitchell J.T.,
RA   Perazzolli M., Eldredge G., Gatto P., Oyzerski R., Moretto M., Gutin N.,
RA   Stefanini M., Chen Y., Segala C., Davenport C., Dematte L., Mraz A.,
RA   Battilana J., Stormo K., Costa F., Tao Q., Si-Ammour A., Harkins T.,
RA   Lackey A., Perbost C., Taillon B., Stella A., Solovyev V., Fawcett J.A.,
RA   Sterck L., Vandepoele K., Grando S.M., Toppo S., Moser C., Lanchbury J.,
RA   Bogden R., Skolnick M., Sgaramella V., Bhatnagar S.K., Fontana P.,
RA   Gutin A., Van de Peer Y., Salamini F., Viola R.;
RT   "A high quality draft consensus sequence of the genome of a heterozygous
RT   grapevine variety.";
RL   PLoS ONE 2:E1326-E1326(2007).
RN   [4]
RP   GENE FAMILY.
RX   PubMed=18997115; DOI=10.1104/pp.108.131052;
RA   Diaz-Riquelme J., Lijavetzky D., Martinez-Zapater J.M., Carmona M.J.;
RT   "Genome-wide analysis of MIKCC-type MADS box genes in grapevine.";
RL   Plant Physiol. 149:354-369(2009).
RN   [5]
RP   GENE FAMILY.
RX   PubMed=26818751; DOI=10.1186/s12864-016-2398-7;
RA   Grimplet J., Martinez-Zapater J.M., Carmona M.J.;
RT   "Structural and functional annotation of the MADS-box transcription factor
RT   family in grapevine.";
RL   BMC Genomics 17:80-80(2016).
CC   -!- FUNCTION: Probable transcription factor involved in flower development.
CC       {ECO:0000250|UniProtKB:Q0HA25}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00251}.
CC   -!- TISSUE SPECIFICITY: Expressed during flower development in stamens,
CC       petals and carpels (PubMed:17920788). Expressed in fruits and seeds
CC       (PubMed:17920788). {ECO:0000269|PubMed:17920788}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CCB44396.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; DQ979341; ABI98021.1; -; mRNA.
DR   EMBL; FN594959; CCB44396.1; ALT_INIT; Genomic_DNA.
DR   EMBL; FN597020; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AM476720; CAN66176.1; -; Genomic_DNA.
DR   RefSeq; NP_001267937.1; NM_001281008.1.
DR   AlphaFoldDB; Q003J2; -.
DR   SMR; Q003J2; -.
DR   STRING; 29760.VIT_04s0023g02820.t01; -.
DR   EnsemblPlants; Vitvi04g01404_t001; Vitvi04g01404_P001; Vitvi04g01404.
DR   GeneID; 100233014; -.
DR   Gramene; Vitvi04g01404_t001; Vitvi04g01404_P001; Vitvi04g01404.
DR   KEGG; vvi:100233014; -.
DR   eggNOG; KOG0014; Eukaryota.
DR   HOGENOM; CLU_053053_0_0_1; -.
DR   OrthoDB; 1142137at2759; -.
DR   Proteomes; UP000009183; Chromosome 4.
DR   ExpressionAtlas; Q003J2; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009908; P:flower development; IEA:UniProtKB-KW.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00265; MADS_MEF2_like; 1.
DR   Gene3D; 3.40.1810.10; -; 1.
DR   InterPro; IPR033896; MADS_MEF2-like.
DR   InterPro; IPR002487; TF_Kbox.
DR   InterPro; IPR002100; TF_MADSbox.
DR   InterPro; IPR036879; TF_MADSbox_sf.
DR   Pfam; PF01486; K-box; 1.
DR   Pfam; PF00319; SRF-TF; 1.
DR   PRINTS; PR00404; MADSDOMAIN.
DR   SMART; SM00432; MADS; 1.
DR   SUPFAM; SSF55455; SSF55455; 1.
DR   PROSITE; PS51297; K_BOX; 1.
DR   PROSITE; PS00350; MADS_BOX_1; 1.
DR   PROSITE; PS50066; MADS_BOX_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Flowering; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..225
FT                   /note="Agamous-like MADS-box protein TM6"
FT                   /id="PRO_0000447287"
FT   DOMAIN          1..61
FT                   /note="MADS-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00251"
FT   DOMAIN          84..174
FT                   /note="K-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00629"
SQ   SEQUENCE   225 AA;  26169 MW;  C1FDD769688AABA6 CRC64;
     MGRGKIEIKR IENPTNRQVT YSKRRNGIFK KAQELTVLCD AKVSLIMFSN TGKFHEYTSP
     TITTKKVYDQ YQKTLGIDLW SSHYERMQEN LRKLKEINNK LRREIRQRMG EDLGDLSIED
     LRGLEQKMDA SLGLVRERKY HVIKTQTETY RKKVRNLEEQ HGNLLLNFEA KCDDPHYGLV
     ENDGDYESAV AFANGASNLY AFRLHQAHPN LHHDGGYGSH DLRLA