TM74B_HUMAN
ID TM74B_HUMAN Reviewed; 256 AA.
AC Q9NUR3; D3DVW5;
DT 10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Transmembrane protein 74B;
GN Name=TMEM74B; Synonyms=C20orf46;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TMEM74 family. {ECO:0000305}.
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DR EMBL; AK002052; BAA92058.1; -; mRNA.
DR EMBL; AL031665; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471133; EAX10647.1; -; Genomic_DNA.
DR EMBL; CH471133; EAX10648.1; -; Genomic_DNA.
DR CCDS; CCDS13011.1; -.
DR RefSeq; NP_001291677.1; NM_001304748.1.
DR RefSeq; NP_001291678.1; NM_001304749.1.
DR RefSeq; NP_060824.1; NM_018354.2.
DR RefSeq; XP_011527584.1; XM_011529282.2.
DR RefSeq; XP_011527585.1; XM_011529283.2.
DR RefSeq; XP_011527586.1; XM_011529284.2.
DR RefSeq; XP_016883413.1; XM_017027924.1.
DR AlphaFoldDB; Q9NUR3; -.
DR SMR; Q9NUR3; -.
DR BioGRID; 120602; 1.
DR IntAct; Q9NUR3; 1.
DR STRING; 9606.ENSP00000371318; -.
DR iPTMnet; Q9NUR3; -.
DR PhosphoSitePlus; Q9NUR3; -.
DR BioMuta; TMEM74B; -.
DR DMDM; 27734260; -.
DR MassIVE; Q9NUR3; -.
DR PaxDb; Q9NUR3; -.
DR PeptideAtlas; Q9NUR3; -.
DR PRIDE; Q9NUR3; -.
DR ProteomicsDB; 82715; -.
DR Antibodypedia; 48589; 14 antibodies from 10 providers.
DR DNASU; 55321; -.
DR Ensembl; ENST00000381894.3; ENSP00000371318.3; ENSG00000125895.6.
DR Ensembl; ENST00000429036.2; ENSP00000400552.2; ENSG00000125895.6.
DR GeneID; 55321; -.
DR KEGG; hsa:55321; -.
DR MANE-Select; ENST00000429036.2; ENSP00000400552.2; NM_001304748.2; NP_001291677.1.
DR UCSC; uc002weq.2; human.
DR CTD; 55321; -.
DR DisGeNET; 55321; -.
DR GeneCards; TMEM74B; -.
DR HGNC; HGNC:15893; TMEM74B.
DR HPA; ENSG00000125895; Tissue enhanced (lung).
DR neXtProt; NX_Q9NUR3; -.
DR OpenTargets; ENSG00000125895; -.
DR PharmGKB; PA25759; -.
DR VEuPathDB; HostDB:ENSG00000125895; -.
DR eggNOG; ENOG502RXT5; Eukaryota.
DR GeneTree; ENSGT00530000063880; -.
DR HOGENOM; CLU_1098206_0_0_1; -.
DR InParanoid; Q9NUR3; -.
DR OMA; NVCFSSE; -.
DR OrthoDB; 1183825at2759; -.
DR PhylomeDB; Q9NUR3; -.
DR TreeFam; TF335735; -.
DR PathwayCommons; Q9NUR3; -.
DR SignaLink; Q9NUR3; -.
DR BioGRID-ORCS; 55321; 11 hits in 1074 CRISPR screens.
DR GenomeRNAi; 55321; -.
DR Pharos; Q9NUR3; Tdark.
DR PRO; PR:Q9NUR3; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q9NUR3; protein.
DR Bgee; ENSG00000125895; Expressed in right uterine tube and 114 other tissues.
DR ExpressionAtlas; Q9NUR3; baseline and differential.
DR Genevisible; Q9NUR3; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR029695; TMEM74-like.
DR PANTHER; PTHR16125; PTHR16125; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..256
FT /note="Transmembrane protein 74B"
FT /id="PRO_0000079431"
FT TRANSMEM 123..143
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 68..99
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 33
FT /note="L -> M (in dbSNP:rs35393697)"
FT /id="VAR_033757"
SQ SEQUENCE 256 AA; 27551 MW; 0824103831C4668A CRC64;
MPPAQGYEFA AAKGPRDELG PSFPMASPPG LELKTLSNGP QAPRRSAPLG PVAPTREGVE
NACFSSEEHE THFQNPGNTR LGSSPSPPGG VSSLPRSQRD DLSLHSEEGP ALEPVSRPVD
YGFVSALVFL VSGILLVVTA YAIPREARVN PDTVTAREME RLEMYYARLG SHLDRCIIAG
LGLLTVGGML LSVLLMVSLC KGELYRRRTF VPGKGSRKTY GSINLRMRQL NGDGGQALVE
NEVVQVSETS HTLQRS
