TM7S3_HUMAN
ID TM7S3_HUMAN Reviewed; 570 AA.
AC Q9NS93; B3KMZ3; Q9NUS4;
DT 20-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Transmembrane 7 superfamily member 3;
DE AltName: Full=Seven span transmembrane protein;
DE Flags: Precursor;
GN Name=TM7SF3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=10828615; DOI=10.1159/000015514;
RA Akashi H., Han H.-J., Iizaka M., Nakajima Y., Furukawa Y., Sugano S.,
RA Imai K., Nakamura Y.;
RT "Isolation and characterization of a novel gene encoding a putative seven-
RT span transmembrane protein, TM7SF3.";
RL Cytogenet. Cell Genet. 88:305-309(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP FUNCTION.
RX PubMed=21853325; DOI=10.1007/s00125-011-2277-3;
RA Beck A., Isaac R., Lavelin I., Hart Y., Volberg T., Shatz-Azoulay H.,
RA Geiger B., Zick Y.;
RT "An siRNA screen identifies transmembrane 7 superfamily member 3 (TM7SF3),
RT a seven transmembrane orphan receptor, as an inhibitor of cytokine-induced
RT death of pancreatic beta cells.";
RL Diabetologia 54:2845-2855(2011).
RN [6]
RP FUNCTION.
RX PubMed=27740623; DOI=10.1038/cdd.2016.108;
RA Isaac R., Goldstein I., Furth N., Zilber N., Streim S., Boura-Halfon S.,
RA Elhanany E., Rotter V., Oren M., Zick Y.;
RT "TM7SF3, a novel p53-regulated homeostatic factor, attenuates cellular
RT stress and the subsequent induction of the unfolded protein response.";
RL Cell Death Differ. 24:132-143(2017).
CC -!- FUNCTION: Involved in the inhibition of cytokine-induced death of
CC pancreatic beta cells. Involved in the promotion of insulin secretion
CC from pancreatic beta cells (PubMed:21853325). Is a downstream
CC transcriptional target of p53/TP53, and acts as a pro-survival
CC homeostatic factor that attenuates the development of cellular stress.
CC Maintains protein homeostasis and promotes cell survival through
CC attenuation of endoplasmic reticulum (ER) stress and the subsequent
CC induction of unfolded protein response (UPR) (PubMed:27740623).
CC {ECO:0000269|PubMed:21853325, ECO:0000269|PubMed:27740623}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10828615};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Widely expressed. Highly expressed in kidney and
CC pancreas. {ECO:0000269|PubMed:10828615}.
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DR EMBL; AB032470; BAA92856.1; -; mRNA.
DR EMBL; AK002031; BAA92046.1; -; mRNA.
DR EMBL; AK023085; BAG51155.1; -; mRNA.
DR EMBL; CH471094; EAW96542.1; -; Genomic_DNA.
DR EMBL; BC005176; AAH05176.1; -; mRNA.
DR CCDS; CCDS8710.1; -.
DR RefSeq; NP_057635.1; NM_016551.2.
DR AlphaFoldDB; Q9NS93; -.
DR SMR; Q9NS93; -.
DR BioGRID; 119723; 7.
DR IntAct; Q9NS93; 2.
DR STRING; 9606.ENSP00000342322; -.
DR GlyGen; Q9NS93; 5 sites.
DR iPTMnet; Q9NS93; -.
DR PhosphoSitePlus; Q9NS93; -.
DR BioMuta; TM7SF3; -.
DR DMDM; 21542266; -.
DR EPD; Q9NS93; -.
DR jPOST; Q9NS93; -.
DR MassIVE; Q9NS93; -.
DR MaxQB; Q9NS93; -.
DR PaxDb; Q9NS93; -.
DR PeptideAtlas; Q9NS93; -.
DR PRIDE; Q9NS93; -.
DR ProteomicsDB; 82516; -.
DR Antibodypedia; 42376; 77 antibodies from 20 providers.
DR DNASU; 51768; -.
DR Ensembl; ENST00000343028.9; ENSP00000342322.4; ENSG00000064115.11.
DR GeneID; 51768; -.
DR KEGG; hsa:51768; -.
DR MANE-Select; ENST00000343028.9; ENSP00000342322.4; NM_016551.3; NP_057635.1.
DR UCSC; uc010sjl.4; human.
DR CTD; 51768; -.
DR GeneCards; TM7SF3; -.
DR HGNC; HGNC:23049; TM7SF3.
DR HPA; ENSG00000064115; Tissue enhanced (kidney).
DR MIM; 605181; gene.
DR neXtProt; NX_Q9NS93; -.
DR OpenTargets; ENSG00000064115; -.
DR PharmGKB; PA134949354; -.
DR VEuPathDB; HostDB:ENSG00000064115; -.
DR eggNOG; ENOG502QS07; Eukaryota.
DR GeneTree; ENSGT00390000008702; -.
DR HOGENOM; CLU_029739_0_0_1; -.
DR InParanoid; Q9NS93; -.
DR OMA; LMWQQER; -.
DR OrthoDB; 1322527at2759; -.
DR PhylomeDB; Q9NS93; -.
DR TreeFam; TF332291; -.
DR PathwayCommons; Q9NS93; -.
DR SignaLink; Q9NS93; -.
DR BioGRID-ORCS; 51768; 13 hits in 1079 CRISPR screens.
DR ChiTaRS; TM7SF3; human.
DR GenomeRNAi; 51768; -.
DR Pharos; Q9NS93; Tbio.
DR PRO; PR:Q9NS93; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q9NS93; protein.
DR Bgee; ENSG00000064115; Expressed in body of pancreas and 192 other tissues.
DR ExpressionAtlas; Q9NS93; baseline and differential.
DR Genevisible; Q9NS93; HS.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0034620; P:cellular response to unfolded protein; IMP:UniProtKB.
DR GO; GO:0043069; P:negative regulation of programmed cell death; IMP:UniProtKB.
DR GO; GO:0032024; P:positive regulation of insulin secretion; IMP:UniProtKB.
DR InterPro; IPR025256; DUF4203.
DR InterPro; IPR042502; TM7SF3.
DR PANTHER; PTHR15937; PTHR15937; 1.
DR Pfam; PF13886; DUF4203; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; Membrane; Reference proteome; Signal;
KW Stress response; Transmembrane; Transmembrane helix.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..570
FT /note="Transmembrane 7 superfamily member 3"
FT /id="PRO_0000022537"
FT TRANSMEM 296..313
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 320..342
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 347..369
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 371..393
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 408..430
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 437..459
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 479..501
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 27
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 61
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 75
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 87
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 264
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 179
FT /note="P -> R (in dbSNP:rs34735713)"
FT /id="VAR_034556"
FT VARIANT 248
FT /note="P -> L (in dbSNP:rs10771314)"
FT /id="VAR_051437"
FT CONFLICT 564
FT /note="E -> A (in Ref. 2; BAA92046)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 570 AA; 64166 MW; CC296D7C22AD894C CRC64;
MGFLQLLVVA VLASEHRVAG AAEVFGNSSE GLIEFSVGKF RYFELNRPFP EEAILHDISS
NVTFLIFQIH SQYQNTTVSF SPTLLSNSSE TGTASGLVFI LRPEQSTCTW YLGTSGIQPV
QNMAILLSYS ERDPVPGGCN LEFDLDIDPN IYLEYNFFET TIKFAPANLG YARGVDPPPC
DAGTDQDSRW RLQYDVYQYF LPENDLTEEM LLKHLQRMVS VPQVKASALK VVTLTANDKT
SVSFSSLPGQ GVIYNVIVWD PFLNTSAAYI PAHTYACSFE AGEGSCASLG RVSSKVFFTL
FALLGFFICF FGHRFWKTEL FFIGFIIMGF FFYILITRLT PIKYDVNLIL TAVTGSVGGM
FLVAVWWRFG ILSICMLCVG LVLGFLISSV TFFTPLGNLK IFHDDGVFWV TFSCIAILIP
VVFMGCLRIL NILTCGVIGS YSVVLAIDSY WSTSLSYITL NVLKRALNKD FHRAFTNVPF
QTNDFIILAV WGMLAVSGIT LQIRRERGRP FFPPHPYKLW KQERERRVTN ILDPSYHIPP
LRERLYGRLT QIKGLFQKEQ PAGERTPLLL
