ID   TM7S3_RAT               Reviewed;         565 AA.
AC   Q5FVF4;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Transmembrane 7 superfamily member 3;
DE   Flags: Precursor;
GN   Name=Tm7sf3;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Spleen;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Involved in the inhibition of cytokine-induced death of
CC       pancreatic beta cells (By similarity). Involved in the promotion of
CC       insulin secretion from pancreatic beta cells (By similarity). Is a
CC       downstream transcriptional target of p53/TP53, and acts as a pro-
CC       survival homeostatic factor that attenuates the development of cellular
CC       stress. Maintains protein homeostasis and promotes cell survival
CC       through attenuation of endoplasmic reticulum (ER) stress and the
CC       subsequent induction of unfolded protein response (UPR) (By
CC       similarity). {ECO:0000250|UniProtKB:Q9CRG1,
CC       ECO:0000250|UniProtKB:Q9NS93}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9NS93};
CC       Multi-pass membrane protein {ECO:0000255}.
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DR   EMBL; BC090030; AAH90030.1; -; mRNA.
DR   RefSeq; NP_001011970.1; NM_001011970.1.
DR   AlphaFoldDB; Q5FVF4; -.
DR   SMR; Q5FVF4; -.
DR   STRING; 10116.ENSRNOP00000002486; -.
DR   GlyGen; Q5FVF4; 4 sites.
DR   iPTMnet; Q5FVF4; -.
DR   PhosphoSitePlus; Q5FVF4; -.
DR   PaxDb; Q5FVF4; -.
DR   Ensembl; ENSRNOT00000002486; ENSRNOP00000002486; ENSRNOG00000001817.
DR   GeneID; 297725; -.
DR   KEGG; rno:297725; -.
DR   UCSC; RGD:1306752; rat.
DR   CTD; 51768; -.
DR   RGD; 1306752; Tm7sf3.
DR   eggNOG; ENOG502QS07; Eukaryota.
DR   GeneTree; ENSGT00390000008702; -.
DR   HOGENOM; CLU_029739_0_0_1; -.
DR   InParanoid; Q5FVF4; -.
DR   OMA; LMWQQER; -.
DR   OrthoDB; 1322527at2759; -.
DR   PhylomeDB; Q5FVF4; -.
DR   TreeFam; TF332291; -.
DR   PRO; PR:Q5FVF4; -.
DR   Proteomes; UP000002494; Chromosome 4.
DR   Bgee; ENSRNOG00000001817; Expressed in colon and 20 other tissues.
DR   Genevisible; Q5FVF4; RN.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0034620; P:cellular response to unfolded protein; ISS:UniProtKB.
DR   GO; GO:0043069; P:negative regulation of programmed cell death; ISS:UniProtKB.
DR   GO; GO:0032024; P:positive regulation of insulin secretion; ISS:UniProtKB.
DR   InterPro; IPR025256; DUF4203.
DR   InterPro; IPR042502; TM7SF3.
DR   PANTHER; PTHR15937; PTHR15937; 1.
DR   Pfam; PF13886; DUF4203; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Glycoprotein; Membrane; Reference proteome; Signal;
KW   Stress response; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..565
FT                   /note="Transmembrane 7 superfamily member 3"
FT                   /id="PRO_0000045329"
FT   TRANSMEM        287..307
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        311..331
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        341..361
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        364..384
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        402..422
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        427..447
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        478..498
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        22
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        56
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        70
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        259
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   565 AA;  63585 MW;  F2E2FD5461604C6C CRC64;
     MWRLRLLVLA VLAAGSAEAQ ANSSDGFLEF SVGKFTYFVL SRRFPQEAVL RHISSNVTFL
     LFQIHSQYQN TTVSYTKTLL PSTSGTGNDR GLVFILRPEQ TVCTWYLETE DTKPVQSVAV
     TLSYSERDPI PGGCNLEFDL DIDPNIYLDY NFFETTIKFA PANIGYARAA EPPPCDVSTG
     QESRWRLRYH VYQYFLPEGD LTEASLLQHL QRMAQVVQVM ASAVKVVTLT ADDKTVVSFS
     SLPGQGVIYN VIVWDPSLNT SAAYVPVHTY ACSFDSVDGN CVPPGRVSTK VFSTLFALLG
     LFTCFFGHRF WKTELFFVGF IFLGFFFYIL ITRLTALKYE VRLVLTAVAG SIGGLLLVAS
     WWRFGILTLC MLCVGLVLGF LVSSGTFFTP LGNLNVFHDD GVFWVTFSCI ALLVPVIFLG
     CLRILNILAC GIVGSYSVVL AINSYMFTSL SYITLNVLRR ALNADFRGAF IRVPFQTNDY
     IILAVWGMLA VTGITLQIRR ERGRPPFPPH PYKLWKQERE RRVTNILDPS HHIPPLRERL
     YGWVARIKEL FQKEQPAGER TPLLL