TM86A_HUMAN
ID TM86A_HUMAN Reviewed; 240 AA.
AC Q8N2M4; Q96AJ0;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Lysoplasmalogenase-like protein TMEM86A;
DE AltName: Full=Transmembrane protein 86A;
GN Name=TMEM86A;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8N2M4; P41181: AQP2; NbExp=3; IntAct=EBI-12015604, EBI-12701138;
CC Q8N2M4; Q92482: AQP3; NbExp=3; IntAct=EBI-12015604, EBI-2808854;
CC Q8N2M4; Q9BXK5: BCL2L13; NbExp=3; IntAct=EBI-12015604, EBI-747430;
CC Q8N2M4; P11912: CD79A; NbExp=3; IntAct=EBI-12015604, EBI-7797864;
CC Q8N2M4; Q8N5K1: CISD2; NbExp=3; IntAct=EBI-12015604, EBI-1045797;
CC Q8N2M4; P34972: CNR2; NbExp=3; IntAct=EBI-12015604, EBI-2835940;
CC Q8N2M4; O75208: COQ9; NbExp=3; IntAct=EBI-12015604, EBI-724524;
CC Q8N2M4; Q7Z7G2: CPLX4; NbExp=3; IntAct=EBI-12015604, EBI-18013275;
CC Q8N2M4; Q96BA8: CREB3L1; NbExp=3; IntAct=EBI-12015604, EBI-6942903;
CC Q8N2M4; Q15125: EBP; NbExp=3; IntAct=EBI-12015604, EBI-3915253;
CC Q8N2M4; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-12015604, EBI-781551;
CC Q8N2M4; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-12015604, EBI-18304435;
CC Q8N2M4; O15552: FFAR2; NbExp=3; IntAct=EBI-12015604, EBI-2833872;
CC Q8N2M4; Q9Y680: FKBP7; NbExp=3; IntAct=EBI-12015604, EBI-3918971;
CC Q8N2M4; Q8TBE3: FNDC9; NbExp=3; IntAct=EBI-12015604, EBI-12142257;
CC Q8N2M4; Q14802-3: FXYD3; NbExp=3; IntAct=EBI-12015604, EBI-12175685;
CC Q8N2M4; Q9NTQ9: GJB4; NbExp=3; IntAct=EBI-12015604, EBI-12831526;
CC Q8N2M4; O95377: GJB5; NbExp=3; IntAct=EBI-12015604, EBI-3909454;
CC Q8N2M4; P36383: GJC1; NbExp=3; IntAct=EBI-12015604, EBI-11979659;
CC Q8N2M4; Q5T7V8: GORAB; NbExp=3; IntAct=EBI-12015604, EBI-3917143;
CC Q8N2M4; O60883: GPR37L1; NbExp=3; IntAct=EBI-12015604, EBI-2927498;
CC Q8N2M4; Q8TDQ0: HAVCR2; NbExp=3; IntAct=EBI-12015604, EBI-11472922;
CC Q8N2M4; Q8N6L0: KASH5; NbExp=3; IntAct=EBI-12015604, EBI-749265;
CC Q8N2M4; Q09470: KCNA1; NbExp=3; IntAct=EBI-12015604, EBI-8286599;
CC Q8N2M4; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-12015604, EBI-2820517;
CC Q8N2M4; Q01362: MS4A2; NbExp=5; IntAct=EBI-12015604, EBI-13384102;
CC Q8N2M4; P15941-11: MUC1; NbExp=3; IntAct=EBI-12015604, EBI-17263240;
CC Q8N2M4; Q6IBW4-4: NCAPH2; NbExp=3; IntAct=EBI-12015604, EBI-10247000;
CC Q8N2M4; Q13113: PDZK1IP1; NbExp=3; IntAct=EBI-12015604, EBI-716063;
CC Q8N2M4; O15173: PGRMC2; NbExp=3; IntAct=EBI-12015604, EBI-1050125;
CC Q8N2M4; Q6UXB8: PI16; NbExp=3; IntAct=EBI-12015604, EBI-12810028;
CC Q8N2M4; Q9H6H4: REEP4; NbExp=3; IntAct=EBI-12015604, EBI-7545592;
CC Q8N2M4; Q7Z5B4-5: RIC3; NbExp=3; IntAct=EBI-12015604, EBI-12375429;
CC Q8N2M4; Q96GF1: RNF185; NbExp=3; IntAct=EBI-12015604, EBI-2340249;
CC Q8N2M4; Q9NY72: SCN3B; NbExp=3; IntAct=EBI-12015604, EBI-17247926;
CC Q8N2M4; Q3KNW5: SLC10A6; NbExp=3; IntAct=EBI-12015604, EBI-18159983;
CC Q8N2M4; P54219-3: SLC18A1; NbExp=3; IntAct=EBI-12015604, EBI-17595455;
CC Q8N2M4; Q9BRI3: SLC30A2; NbExp=3; IntAct=EBI-12015604, EBI-8644112;
CC Q8N2M4; Q9NQQ7-3: SLC35C2; NbExp=3; IntAct=EBI-12015604, EBI-17295964;
CC Q8N2M4; Q9NP94: SLC39A2; NbExp=3; IntAct=EBI-12015604, EBI-12898013;
CC Q8N2M4; Q8WWF3: SSMEM1; NbExp=3; IntAct=EBI-12015604, EBI-17280858;
CC Q8N2M4; Q8WY91: THAP4; NbExp=3; IntAct=EBI-12015604, EBI-726691;
CC Q8N2M4; Q9NPL8: TIMMDC1; NbExp=3; IntAct=EBI-12015604, EBI-6268651;
CC Q8N2M4; O15393-2: TMPRSS2; NbExp=3; IntAct=EBI-12015604, EBI-12345267;
CC Q8N2M4; O43914: TYROBP; NbExp=3; IntAct=EBI-12015604, EBI-2214794;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TMEM86 family. {ECO:0000305}.
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DR EMBL; AK074600; BAC11084.1; -; mRNA.
DR EMBL; BC017073; AAH17073.2; -; mRNA.
DR EMBL; BC035692; AAH35692.1; -; mRNA.
DR CCDS; CCDS7844.1; -.
DR RefSeq; NP_699178.1; NM_153347.2.
DR AlphaFoldDB; Q8N2M4; -.
DR BioGRID; 126831; 49.
DR IntAct; Q8N2M4; 46.
DR MINT; Q8N2M4; -.
DR STRING; 9606.ENSP00000280734; -.
DR BioMuta; TMEM86A; -.
DR DMDM; 74728715; -.
DR MassIVE; Q8N2M4; -.
DR PaxDb; Q8N2M4; -.
DR PeptideAtlas; Q8N2M4; -.
DR PRIDE; Q8N2M4; -.
DR ProteomicsDB; 71716; -.
DR Antibodypedia; 71292; 17 antibodies from 9 providers.
DR DNASU; 144110; -.
DR Ensembl; ENST00000280734.3; ENSP00000280734.2; ENSG00000151117.9.
DR GeneID; 144110; -.
DR KEGG; hsa:144110; -.
DR MANE-Select; ENST00000280734.3; ENSP00000280734.2; NM_153347.3; NP_699178.1.
DR UCSC; uc001moz.2; human.
DR CTD; 144110; -.
DR GeneCards; TMEM86A; -.
DR HGNC; HGNC:26890; TMEM86A.
DR HPA; ENSG00000151117; Tissue enhanced (skin).
DR neXtProt; NX_Q8N2M4; -.
DR OpenTargets; ENSG00000151117; -.
DR PharmGKB; PA142670737; -.
DR VEuPathDB; HostDB:ENSG00000151117; -.
DR eggNOG; KOG4804; Eukaryota.
DR GeneTree; ENSGT00390000007101; -.
DR HOGENOM; CLU_079086_1_1_1; -.
DR InParanoid; Q8N2M4; -.
DR OMA; ACFKCLP; -.
DR OrthoDB; 1516092at2759; -.
DR PhylomeDB; Q8N2M4; -.
DR TreeFam; TF324663; -.
DR PathwayCommons; Q8N2M4; -.
DR SignaLink; Q8N2M4; -.
DR BioGRID-ORCS; 144110; 15 hits in 1074 CRISPR screens.
DR GenomeRNAi; 144110; -.
DR Pharos; Q8N2M4; Tdark.
DR PRO; PR:Q8N2M4; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8N2M4; protein.
DR Bgee; ENSG00000151117; Expressed in adrenal tissue and 128 other tissues.
DR Genevisible; Q8N2M4; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0047408; F:alkenylglycerophosphocholine hydrolase activity; IBA:GO_Central.
DR GO; GO:0047409; F:alkenylglycerophosphoethanolamine hydrolase activity; IBA:GO_Central.
DR InterPro; IPR012506; YhhN.
DR PANTHER; PTHR31885; PTHR31885; 1.
DR Pfam; PF07947; YhhN; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..240
FT /note="Lysoplasmalogenase-like protein TMEM86A"
FT /id="PRO_0000201838"
FT TRANSMEM 22..42
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..64
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 71..91
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..113
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 175..195
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 207..227
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VARIANT 215
FT /note="V -> A (in dbSNP:rs7945285)"
FT /id="VAR_034564"
SQ SEQUENCE 240 AA; 26398 MW; 2FABCC64A964BAA9 CRC64;
MVSPVTVVKS EGPKLVPFFK ATCVYFVLWL PSSSPSWVST LIKCLPIFCL WLFLLAHGLG
FLLAHPSATR IFVGLVFSAV GDAFLIWQDQ GYFVHGLLMF AVTHMFYASA FGMQPLALRT
GLVMAALSGL CYALLYPCLS GAFTYLVGVY VALIGFMGWR AMAGLRLAGA DWRWTELAAG
SGALFFIISD LTIALNKFCF PVPYSRALIM STYYVAQMLV ALSAVESREP VEHYRLTKAN
