TM86A_MOUSE
ID TM86A_MOUSE Reviewed; 241 AA.
AC Q9D8N3; Q8C6I3;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Lysoplasmalogenase-like protein TMEM86A;
DE AltName: Full=Transmembrane protein 86A;
GN Name=Tmem86a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Kidney, and Pancreas;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TMEM86 family. {ECO:0000305}.
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DR EMBL; AK007864; BAB25316.1; -; mRNA.
DR EMBL; AK075589; BAC35840.1; -; mRNA.
DR EMBL; BC056619; AAH56619.1; -; mRNA.
DR CCDS; CCDS39966.1; -.
DR RefSeq; NP_080712.1; NM_026436.3.
DR AlphaFoldDB; Q9D8N3; -.
DR STRING; 10090.ENSMUSP00000010451; -.
DR PaxDb; Q9D8N3; -.
DR PRIDE; Q9D8N3; -.
DR ProteomicsDB; 259567; -.
DR Antibodypedia; 71292; 17 antibodies from 9 providers.
DR Ensembl; ENSMUST00000010451; ENSMUSP00000010451; ENSMUSG00000010307.
DR GeneID; 67893; -.
DR KEGG; mmu:67893; -.
DR UCSC; uc009gzy.1; mouse.
DR CTD; 144110; -.
DR MGI; MGI:1915143; Tmem86a.
DR VEuPathDB; HostDB:ENSMUSG00000010307; -.
DR eggNOG; KOG4804; Eukaryota.
DR GeneTree; ENSGT00390000007101; -.
DR HOGENOM; CLU_079086_1_1_1; -.
DR InParanoid; Q9D8N3; -.
DR OMA; ACFKCLP; -.
DR OrthoDB; 1516092at2759; -.
DR PhylomeDB; Q9D8N3; -.
DR TreeFam; TF324663; -.
DR BioGRID-ORCS; 67893; 3 hits in 72 CRISPR screens.
DR ChiTaRS; Tmem86a; mouse.
DR PRO; PR:Q9D8N3; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q9D8N3; protein.
DR Bgee; ENSMUSG00000010307; Expressed in cumulus cell and 219 other tissues.
DR Genevisible; Q9D8N3; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0047408; F:alkenylglycerophosphocholine hydrolase activity; IBA:GO_Central.
DR GO; GO:0047409; F:alkenylglycerophosphoethanolamine hydrolase activity; IBA:GO_Central.
DR InterPro; IPR012506; YhhN.
DR PANTHER; PTHR31885; PTHR31885; 1.
DR Pfam; PF07947; YhhN; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..241
FT /note="Lysoplasmalogenase-like protein TMEM86A"
FT /id="PRO_0000201839"
FT TRANSMEM 15..35
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 36..56
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 67..87
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..113
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..154
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 175..195
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 207..227
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 29
FT /note="W -> L (in Ref. 1; BAC35840)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 241 AA; 26273 MW; 11B34A518B5D84D9 CRC64;
MVSPVTVVKS EGPKLVPFFK ATCVYFVLWL PSSSPSWVSA LIKCLPIFCL WLFLLAHGVR
FLLAHPSASL IFVGLVFSAV GDAFLIWQDH GYFEHGLLMF AVAHILYAAA FGMRPLALRT
GLVIGVLSGL CYALLYPGLS GAFTYLVGVY VALISFMGWR AMAGLRLVGA AWRWTELAAG
GGALLFILSD LTIALNKFCF PVPYSRALIM STYYAAQMLI ALSAVESREP VGEDYRLSKA
D
