ID   TM86B_BOVIN             Reviewed;         224 AA.
AC   Q3T0W0;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Lysoplasmalogenase;
DE            EC=3.3.2.2 {ECO:0000250|UniProtKB:Q8N661};
DE   AltName: Full=Transmembrane protein 86B;
GN   Name=TMEM86B;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Enzyme catalyzing the degradation of lysoplasmalogen.
CC       Lysoplasmalogens are formed by the hydrolysis of the abundant membrane
CC       glycerophospholipids plasmalogens. May control the respective levels of
CC       plasmalogens and lysoplasmalogens in cells and modulate cell membrane
CC       properties. {ECO:0000250|UniProtKB:Q8N661}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O = a 2,3-
CC         saturated aldehyde + sn-glycerol 3-phosphocholine;
CC         Xref=Rhea:RHEA:22544, ChEBI:CHEBI:15377, ChEBI:CHEBI:16870,
CC         ChEBI:CHEBI:73359, ChEBI:CHEBI:77287; EC=3.3.2.2;
CC         Evidence={ECO:0000250|UniProtKB:Q8N661};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = a
CC         2,3-saturated aldehyde + sn-glycero-3-phosphoethanolamine;
CC         Xref=Rhea:RHEA:16905, ChEBI:CHEBI:15377, ChEBI:CHEBI:73359,
CC         ChEBI:CHEBI:77288, ChEBI:CHEBI:143890; EC=3.3.2.2;
CC         Evidence={ECO:0000250|UniProtKB:Q8N661};
CC   -!- ACTIVITY REGULATION: Competitively inhibited by lysophosphatidic acid.
CC       {ECO:0000250|UniProtKB:Q8N661}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000305}. Cytoplasm {ECO:0000250|UniProtKB:Q8N661}.
CC   -!- SIMILARITY: Belongs to the TMEM86 family. {ECO:0000305}.
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DR   EMBL; BC102239; AAI02240.1; -; mRNA.
DR   RefSeq; NP_001029700.1; NM_001034528.1.
DR   AlphaFoldDB; Q3T0W0; -.
DR   STRING; 9913.ENSBTAP00000016167; -.
DR   PaxDb; Q3T0W0; -.
DR   Ensembl; ENSBTAT00000076823; ENSBTAP00000061754; ENSBTAG00000051212.
DR   GeneID; 518466; -.
DR   KEGG; bta:518466; -.
DR   CTD; 255043; -.
DR   VEuPathDB; HostDB:ENSBTAG00000051212; -.
DR   VGNC; VGNC:36117; TMEM86B.
DR   eggNOG; KOG4804; Eukaryota.
DR   GeneTree; ENSGT00390000007101; -.
DR   HOGENOM; CLU_079086_1_0_1; -.
DR   InParanoid; Q3T0W0; -.
DR   OMA; AWDTFAQ; -.
DR   OrthoDB; 1516092at2759; -.
DR   TreeFam; TF324663; -.
DR   Reactome; R-BTA-1482788; Acyl chain remodelling of PC.
DR   Proteomes; UP000009136; Chromosome 18.
DR   Bgee; ENSBTAG00000051212; Expressed in liver and 99 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; ISS:UniProtKB.
DR   GO; GO:0047408; F:alkenylglycerophosphocholine hydrolase activity; ISS:UniProtKB.
DR   GO; GO:0047409; F:alkenylglycerophosphoethanolamine hydrolase activity; ISS:UniProtKB.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0046485; P:ether lipid metabolic process; ISS:UniProtKB.
DR   InterPro; IPR012506; YhhN.
DR   PANTHER; PTHR31885; PTHR31885; 1.
DR   Pfam; PF07947; YhhN; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Hydrolase; Lipid metabolism; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..224
FT                   /note="Lysoplasmalogenase"
FT                   /id="PRO_0000201840"
FT   TRANSMEM        20..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        45..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        73..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        112..132
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        141..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        173..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        196..216
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   224 AA;  24681 MW;  1AF65420176975A8 CRC64;
     MDARKEGLLR KPRFSAQPRV GMGLLPFFLA CAVYLLVRNA DQPPWVNVLL KILPVLYLAG
     FLGTAHPGGG YRALLQGALL CSAVGDACLV WPEALRYGMA AFGLAHLLYL RAFGLTPLKP
     GLLLPLLLVS ALYFRVLHPH MPPQVVWPLL AYSIVLVAML WRGLARGGSA HWGALLFVLS
     DSVLAWNIFT YLVPHGHLLV MTTYYSAQML ITLSAFQNPR LKSH