ID   TM86B_PIG               Reviewed;         226 AA.
AC   F1RMN2;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   03-MAY-2011, sequence version 1.
DT   03-AUG-2022, entry version 44.
DE   RecName: Full=Lysoplasmalogenase;
DE            EC=3.3.2.2 {ECO:0000250|UniProtKB:Q8N661};
DE   AltName: Full=Transmembrane protein 86B;
GN   Name=TMEM86B;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Porcine genome sequencing project;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Enzyme catalyzing the degradation of lysoplasmalogen.
CC       Lysoplasmalogens are formed by the hydrolysis of the abundant membrane
CC       glycerophospholipids plasmalogens. May control the respective levels of
CC       plasmalogens and lysoplasmalogens in cells and modulate cell membrane
CC       properties. {ECO:0000250|UniProtKB:Q8N661}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O = a 2,3-
CC         saturated aldehyde + sn-glycerol 3-phosphocholine;
CC         Xref=Rhea:RHEA:22544, ChEBI:CHEBI:15377, ChEBI:CHEBI:16870,
CC         ChEBI:CHEBI:73359, ChEBI:CHEBI:77287; EC=3.3.2.2;
CC         Evidence={ECO:0000250|UniProtKB:Q8N661};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = a
CC         2,3-saturated aldehyde + sn-glycero-3-phosphoethanolamine;
CC         Xref=Rhea:RHEA:16905, ChEBI:CHEBI:15377, ChEBI:CHEBI:73359,
CC         ChEBI:CHEBI:77288, ChEBI:CHEBI:143890; EC=3.3.2.2;
CC         Evidence={ECO:0000250|UniProtKB:Q8N661};
CC   -!- ACTIVITY REGULATION: Competitively inhibited by lysophosphatidic acid.
CC       {ECO:0000250|UniProtKB:Q8N661}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000305}. Cytoplasm {ECO:0000250|UniProtKB:Q8N661}.
CC   -!- SIMILARITY: Belongs to the TMEM86 family. {ECO:0000305}.
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DR   EMBL; FP245423; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001230205.1; NM_001243276.1.
DR   RefSeq; XP_013844157.1; XM_013988703.1.
DR   AlphaFoldDB; F1RMN2; -.
DR   STRING; 9823.ENSSSCP00000003581; -.
DR   PaxDb; F1RMN2; -.
DR   Ensembl; ENSSSCT00000003666; ENSSSCP00000003581; ENSSSCG00000003302.
DR   GeneID; 100514582; -.
DR   KEGG; ssc:100514582; -.
DR   CTD; 255043; -.
DR   VGNC; VGNC:94211; TMEM86B.
DR   eggNOG; KOG4804; Eukaryota.
DR   GeneTree; ENSGT00390000007101; -.
DR   HOGENOM; CLU_079086_1_0_1; -.
DR   InParanoid; F1RMN2; -.
DR   OMA; AWDTFAQ; -.
DR   OrthoDB; 1516092at2759; -.
DR   TreeFam; TF324663; -.
DR   Reactome; R-SSC-1482788; Acyl chain remodelling of PC.
DR   Proteomes; UP000008227; Chromosome 6.
DR   Proteomes; UP000314985; Unplaced.
DR   Bgee; ENSSSCG00000003302; Expressed in liver and 22 other tissues.
DR   ExpressionAtlas; F1RMN2; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; ISS:UniProtKB.
DR   GO; GO:0047408; F:alkenylglycerophosphocholine hydrolase activity; ISS:UniProtKB.
DR   GO; GO:0047409; F:alkenylglycerophosphoethanolamine hydrolase activity; ISS:UniProtKB.
DR   GO; GO:0046485; P:ether lipid metabolic process; ISS:UniProtKB.
DR   InterPro; IPR012506; YhhN.
DR   PANTHER; PTHR31885; PTHR31885; 1.
DR   Pfam; PF07947; YhhN; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Hydrolase; Lipid metabolism; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..226
FT                   /note="Lysoplasmalogenase"
FT                   /id="PRO_0000410970"
FT   TRANSMEM        21..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        47..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        97..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        123..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        147..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        172..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        197..217
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   226 AA;  24489 MW;  E60A44B77FB9A18D CRC64;
     MDPGKEGLPR KPRFSAQQLH VGKWLSPFFF TCAVYFLLWI PDDQPSWVGA LVKCLPVLSL
     VVFLRAVDAG GGYSARLQGA LLCSAVGDAC LVWPEAFLHG VAAFAAAHLL YLWAFGLTPL
     QPGLLLLVIL AALPYYGLLL WHLPPDLVLA LTAYSLALAT MLWRGLARGG STGWGALLFT
     LSDTTLAWNA FAQPLPHARL VVMTTYYSAQ VLISLSVSQS PKLKPN