ID   TM87A_XENTR             Reviewed;         541 AA.
AC   Q28EW0;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Transmembrane protein 87A {ECO:0000305};
DE   Flags: Precursor;
GN   Name=tmem87a {ECO:0000250|UniProtKB:Q8NBN3};
GN   ORFNames=TGas047b06.1 {ECO:0000312|EMBL:CAJ82744.1};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in retrograde transport from endosomes to the
CC       trans-Golgi network (TGN). {ECO:0000250|UniProtKB:Q8NBN3}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC       {ECO:0000250|UniProtKB:Q8NBN3}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the LU7TM family. TMEM87 subfamily.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR762316; CAJ82744.1; -; mRNA.
DR   RefSeq; NP_001016057.1; NM_001016057.2.
DR   AlphaFoldDB; Q28EW0; -.
DR   STRING; 8364.ENSXETP00000030172; -.
DR   PaxDb; Q28EW0; -.
DR   GeneID; 548811; -.
DR   KEGG; xtr:548811; -.
DR   CTD; 84910; -.
DR   Xenbase; XB-GENE-963260; tmem87b.
DR   eggNOG; KOG2568; Eukaryota.
DR   HOGENOM; CLU_027525_0_0_1; -.
DR   InParanoid; Q28EW0; -.
DR   OrthoDB; 1448608at2759; -.
DR   Proteomes; UP000008143; Chromosome 5.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000013776; Expressed in egg cell and 15 other tissues.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR   GO; GO:0032580; C:Golgi cisterna membrane; ISS:UniProtKB.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0042147; P:retrograde transport, endosome to Golgi; IBA:GO_Central.
DR   InterPro; IPR009637; GPR107/GPR108-like.
DR   PANTHER; PTHR21229; PTHR21229; 1.
DR   Pfam; PF06814; Lung_7-TM_R; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Golgi apparatus; Membrane; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..541
FT                   /note="Transmembrane protein 87A"
FT                   /id="PRO_0000270753"
FT   TOPO_DOM        27..209
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        210..230
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        231..241
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        242..262
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        263..293
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        294..314
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        315..316
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        317..337
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        338..344
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        345..365
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        366..384
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        385..405
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        406..422
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        423..443
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        444..541
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   CARBOHYD        52
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        109
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        148
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        189
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   541 AA;  61912 MW;  90EF57B9D1E6FD2C CRC64;
     MAAASFQPLK CLLLWVFFVI TPPVKAVPEP GIWTVPIGSG AGSLFFRKTL YNSTNIKVKL
     ISPNCPTPVK LTVKWYLRSH RCYNQFTNLE EVLERHHTNL DTTDNFCKNV SKPDFCDKNE
     DKNIDCNKDM HALPTLKMSK LVPKISVNQS AGSKNPLNQM DFDIVARTYQ DGPYLFVLQV
     KGDENVKWNL SVTVSMKGPH GFISASDWPL MIFYMVMCIM YILLALLWFI WSACYWKDLL
     RIQFWIAAVI FLGMLEKAVY YAEYQNTDNT GVSSHGLLIF AELISSIKRT LARLLVTIVS
     LGYGIIKPRL GAVMHRVVGM GVLYFVFAAV EGVMRIIGAK EYDLVLLAGI PLALLDSGLC
     WWIFVSLAQT MKTLKLRKNT VKYSLYRHFT NTLIFAILAS IIFMIWRTKK FQLVDCQADW
     MELWVDDAYW RFLFFIILLV IMFLWRPSAN NQRYAFTPLI DDSDDEVEEF LVTDHLAEGM
     KLRGTKPECN GAPKPPATNI DEDLKWVEEN IPSSFADAAL PVLMDSDEEI MMTKYEMSKI
     E