TM87B_MOUSE
ID TM87B_MOUSE Reviewed; 555 AA.
AC Q8BKU8; A2AN76; Q3T9D2; Q8K0G0; Q9D001;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Transmembrane protein 87B {ECO:0000305};
DE Flags: Precursor;
GN Name=Tmem87b {ECO:0000312|MGI:MGI:1919727};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 15-555 (ISOFORM 3).
RC STRAIN=C57BL/6J, and NOD; TISSUE=Embryo, Liver, and Spleen;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-555 (ISOFORM 1).
RC TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in retrograde transport from endosomes to the
CC trans-Golgi network (TGN). {ECO:0000250|UniProtKB:Q96K49}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000250|UniProtKB:Q96K49}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8BKU8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BKU8-2; Sequence=VSP_026220;
CC Name=3;
CC IsoId=Q8BKU8-3; Sequence=VSP_026221;
CC -!- SIMILARITY: Belongs to the LU7TM family. TMEM87 subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB27940.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK011959; BAB27940.1; ALT_FRAME; mRNA.
DR EMBL; AK050203; BAC34120.1; -; mRNA.
DR EMBL; AK171811; BAE42677.1; -; mRNA.
DR EMBL; AK172611; BAE43092.1; -; mRNA.
DR EMBL; AL808104; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC031488; AAH31488.2; -; mRNA.
DR CCDS; CCDS38234.1; -. [Q8BKU8-1]
DR RefSeq; NP_082524.2; NM_028248.2. [Q8BKU8-1]
DR RefSeq; XP_011238093.1; XM_011239791.2. [Q8BKU8-2]
DR AlphaFoldDB; Q8BKU8; -.
DR SMR; Q8BKU8; -.
DR BioGRID; 215390; 2.
DR STRING; 10090.ENSMUSP00000105954; -.
DR GlyGen; Q8BKU8; 4 sites.
DR iPTMnet; Q8BKU8; -.
DR PhosphoSitePlus; Q8BKU8; -.
DR jPOST; Q8BKU8; -.
DR MaxQB; Q8BKU8; -.
DR PaxDb; Q8BKU8; -.
DR PeptideAtlas; Q8BKU8; -.
DR PRIDE; Q8BKU8; -.
DR ProteomicsDB; 260705; -. [Q8BKU8-1]
DR ProteomicsDB; 260706; -. [Q8BKU8-2]
DR ProteomicsDB; 260707; -. [Q8BKU8-3]
DR Antibodypedia; 33259; 69 antibodies from 16 providers.
DR Ensembl; ENSMUST00000110325; ENSMUSP00000105954; ENSMUSG00000014353. [Q8BKU8-1]
DR GeneID; 72477; -.
DR KEGG; mmu:72477; -.
DR UCSC; uc008mgx.1; mouse. [Q8BKU8-1]
DR UCSC; uc012cds.1; mouse. [Q8BKU8-3]
DR CTD; 84910; -.
DR MGI; MGI:1919727; Tmem87b.
DR VEuPathDB; HostDB:ENSMUSG00000014353; -.
DR eggNOG; KOG2568; Eukaryota.
DR GeneTree; ENSGT00940000156844; -.
DR HOGENOM; CLU_027525_1_1_1; -.
DR InParanoid; Q8BKU8; -.
DR OMA; PCIFDDR; -.
DR OrthoDB; 1448608at2759; -.
DR PhylomeDB; Q8BKU8; -.
DR TreeFam; TF314452; -.
DR BioGRID-ORCS; 72477; 2 hits in 75 CRISPR screens.
DR ChiTaRS; Tmem87b; mouse.
DR PRO; PR:Q8BKU8; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8BKU8; protein.
DR Bgee; ENSMUSG00000014353; Expressed in cumulus cell and 223 other tissues.
DR ExpressionAtlas; Q8BKU8; baseline and differential.
DR Genevisible; Q8BKU8; MM.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; ISO:MGI.
DR InterPro; IPR009637; GPR107/GPR108-like.
DR PANTHER; PTHR21229; PTHR21229; 1.
DR Pfam; PF06814; Lung_7-TM_R; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Golgi apparatus; Membrane;
KW Phosphoprotein; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..42
FT /evidence="ECO:0000255"
FT CHAIN 43..555
FT /note="Transmembrane protein 87B"
FT /id="PRO_0000291754"
FT TOPO_DOM 43..216
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 217..237
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 238..248
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 249..269
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 270..300
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 301..321
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 322..323
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 324..344
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 345..351
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 352..372
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 373..394
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 395..415
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 416..429
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 430..450
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 451..555
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT MOD_RES 470
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96K49"
FT MOD_RES 497
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96K49"
FT MOD_RES 534
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96K49"
FT CARBOHYD 68
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 160
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 198
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 275
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..65
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_026220"
FT VAR_SEQ 371..373
FT /note="FIS -> SFTMSFQNSWC (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_026221"
FT CONFLICT 15
FT /note="L -> A (in Ref. 1; BAB27940)"
FT /evidence="ECO:0000305"
FT CONFLICT 92
FT /note="H -> L (in Ref. 1; BAE42677/BAE43092)"
FT /evidence="ECO:0000305"
FT CONFLICT 223
FT /note="V -> G (in Ref. 1; BAB27940)"
FT /evidence="ECO:0000305"
FT CONFLICT 266
FT /note="V -> I (in Ref. 1; BAB27940)"
FT /evidence="ECO:0000305"
FT CONFLICT 291
FT /note="I -> R (in Ref. 1; BAE42677/BAE43092)"
FT /evidence="ECO:0000305"
FT CONFLICT 376
FT /note="Q -> E (in Ref. 1; BAB27940)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 555 AA; 62898 MW; 814A2A7DD5C4DD25 CRC64;
MAAACRSEAG LLPSLLCRRP AGAQLLRVAL CLLCWVPAAV DAVPELGLWT RTVNDKSGPL
VFRKTMFNST EIKFSVKSFS CSGPVKFTIE WHLKYHTCHN DYPDLEEELS QRHELHADPD
VCAYFKNIDC WTTKSENLDC SSDSQAFPSL NNKELTGIRN ISSQEGSTDV VARTQKDGFH
IFIVSIKTEK TDAVWDLNVS LSMVGPHGYI SASDWPLMIF YMVMCIVYIL YGVLWLLWSA
CYWKDILRIQ FWIAAVIFLG MLEKAVFYSE YQNINSTGLS TQGLLIFAEL ISAVKRTLAR
LLVIIVSLGY GIVKPRLGTV MHRVIGLGLL YLIFAAIEGV MRVIGGSKHL AVVLTDIVLA
VIDSIFVWFI FISLAQTMKT LRLRKNTVKF SLYRHFTNTL IFAVLASIVF MVWTTKTFRI
AKCQSDWMEL WVDDAFWSFL FSVILIVIMF LWRPSANNQR YAFMPLIDDS DDEVEEFMVT
SENLTEGIKL RASKTVSNGT AKPTSDNFDE DLKWVEENIP SSFTDVALPV LVDSDEEIMT
RSEIAEKMFS SEKIM
