TM88B_HUMAN
ID TM88B_HUMAN Reviewed; 163 AA.
AC A6NKF7;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=Transmembrane protein 88B;
GN Name=TMEM88B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TMEM88 family. {ECO:0000305}.
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DR EMBL; AL391244; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS57964.1; -.
DR RefSeq; NP_001140157.1; NM_001146685.1.
DR AlphaFoldDB; A6NKF7; -.
DR BioGRID; 569197; 1.
DR STRING; 9606.ENSP00000455099; -.
DR iPTMnet; A6NKF7; -.
DR PhosphoSitePlus; A6NKF7; -.
DR BioMuta; TMEM88B; -.
DR MassIVE; A6NKF7; -.
DR PaxDb; A6NKF7; -.
DR PeptideAtlas; A6NKF7; -.
DR PRIDE; A6NKF7; -.
DR ProteomicsDB; 1412; -.
DR Antibodypedia; 74565; 4 antibodies from 4 providers.
DR DNASU; 643965; -.
DR Ensembl; ENST00000378821.4; ENSP00000455099.1; ENSG00000205116.4.
DR GeneID; 643965; -.
DR KEGG; hsa:643965; -.
DR MANE-Select; ENST00000378821.4; ENSP00000455099.1; NM_001146685.2; NP_001140157.1.
DR UCSC; uc010nyp.2; human.
DR CTD; 643965; -.
DR DisGeNET; 643965; -.
DR GeneCards; TMEM88B; -.
DR HGNC; HGNC:37099; TMEM88B.
DR HPA; ENSG00000205116; Tissue enriched (brain).
DR neXtProt; NX_A6NKF7; -.
DR OpenTargets; ENSG00000205116; -.
DR PharmGKB; PA165752745; -.
DR VEuPathDB; HostDB:ENSG00000205116; -.
DR eggNOG; ENOG502RYZS; Eukaryota.
DR GeneTree; ENSGT00730000111599; -.
DR HOGENOM; CLU_1602208_0_0_1; -.
DR InParanoid; A6NKF7; -.
DR OMA; EQLCAWV; -.
DR OrthoDB; 1609820at2759; -.
DR PhylomeDB; A6NKF7; -.
DR TreeFam; TF332743; -.
DR PathwayCommons; A6NKF7; -.
DR SignaLink; A6NKF7; -.
DR BioGRID-ORCS; 643965; 13 hits in 1060 CRISPR screens.
DR Pharos; A6NKF7; Tdark.
DR PRO; PR:A6NKF7; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; A6NKF7; protein.
DR Bgee; ENSG00000205116; Expressed in C1 segment of cervical spinal cord and 71 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0030165; F:PDZ domain binding; IBA:GO_Central.
DR InterPro; IPR033355; TMEM88.
DR PANTHER; PTHR28628; PTHR28628; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..163
FT /note="Transmembrane protein 88B"
FT /id="PRO_0000346446"
FT TRANSMEM 51..71
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 136..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 163 AA; 17097 MW; CFA11730EC5557DB CRC64;
MSEQGRETEE EEGGGGASDT APMLPRGPPD HQASALTCPG WSGPPLLPGR LLAGLLLHLL
LPAAAFLLVL LPAAAVVYLG FLCHSRVHPA PGPRCRALFS DRGSAALIVF GLLSLPPLLV
LASAVRARLA RRLRPLLPPP AGTPGPRRPP GRPDEDEQLC AWV
