TM9S1_MOUSE
ID TM9S1_MOUSE Reviewed; 606 AA.
AC Q9DBU0; Q3U7S4; Q8VD27; Q922J5; Q9ET29;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2003, sequence version 2.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Transmembrane 9 superfamily member 1;
DE Flags: Precursor;
GN Name=Tm9sf1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Warner S.J., Lomax M.I.;
RT "Evolution of the TM9 super family of membrane spanning proteins.";
RL Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Bone marrow, and Lung;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary gland, and Salivary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Plays an essential role in autophagy. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Lysosome membrane; Multi-pass membrane protein.
CC Cytoplasmic vesicle, autophagosome membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF269152; AAF98161.1; -; mRNA.
DR EMBL; AK004754; BAB23535.2; -; mRNA.
DR EMBL; AK152476; BAE31250.1; -; mRNA.
DR EMBL; AK152540; BAE31295.1; -; mRNA.
DR EMBL; BC007187; AAH07187.1; -; mRNA.
DR EMBL; BC017617; AAH17617.1; -; mRNA.
DR CCDS; CCDS27122.1; -.
DR RefSeq; NP_083056.2; NM_028780.3.
DR RefSeq; XP_017171706.1; XM_017316217.1.
DR AlphaFoldDB; Q9DBU0; -.
DR BioGRID; 216520; 3.
DR STRING; 10090.ENSMUSP00000113782; -.
DR GlyGen; Q9DBU0; 3 sites.
DR iPTMnet; Q9DBU0; -.
DR PhosphoSitePlus; Q9DBU0; -.
DR EPD; Q9DBU0; -.
DR jPOST; Q9DBU0; -.
DR MaxQB; Q9DBU0; -.
DR PaxDb; Q9DBU0; -.
DR PRIDE; Q9DBU0; -.
DR ProteomicsDB; 259233; -.
DR DNASU; 74140; -.
DR Ensembl; ENSMUST00000002391; ENSMUSP00000002391; ENSMUSG00000002320.
DR Ensembl; ENSMUST00000120041; ENSMUSP00000112893; ENSMUSG00000002320.
DR Ensembl; ENSMUST00000121791; ENSMUSP00000112764; ENSMUSG00000002320.
DR Ensembl; ENSMUST00000122358; ENSMUSP00000113782; ENSMUSG00000002320.
DR GeneID; 74140; -.
DR KEGG; mmu:74140; -.
DR UCSC; uc007tzs.1; mouse.
DR CTD; 10548; -.
DR MGI; MGI:1921390; Tm9sf1.
DR VEuPathDB; HostDB:ENSMUSG00000002320; -.
DR eggNOG; KOG1277; Eukaryota.
DR GeneTree; ENSGT00940000158667; -.
DR HOGENOM; CLU_010714_0_2_1; -.
DR InParanoid; Q9DBU0; -.
DR OMA; EWNGDRI; -.
DR OrthoDB; 641127at2759; -.
DR PhylomeDB; Q9DBU0; -.
DR TreeFam; TF328663; -.
DR BioGRID-ORCS; 74140; 5 hits in 72 CRISPR screens.
DR ChiTaRS; Tm9sf1; mouse.
DR PRO; PR:Q9DBU0; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q9DBU0; protein.
DR Bgee; ENSMUSG00000002320; Expressed in right kidney and 89 other tissues.
DR ExpressionAtlas; Q9DBU0; baseline and differential.
DR Genevisible; Q9DBU0; MM.
DR GO; GO:0000421; C:autophagosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR GO; GO:0072657; P:protein localization to membrane; IBA:GO_Central.
DR InterPro; IPR004240; EMP70.
DR PANTHER; PTHR10766; PTHR10766; 1.
DR Pfam; PF02990; EMP70; 1.
PE 2: Evidence at transcript level;
KW Autophagy; Cytoplasmic vesicle; Glycoprotein; Lysosome; Membrane;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..606
FT /note="Transmembrane 9 superfamily member 1"
FT /id="PRO_0000034362"
FT TRANSMEM 237..257
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 310..330
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 339..359
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 373..393
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 412..432
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 469..489
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 499..519
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 535..555
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 570..590
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 178
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 401
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 559
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 385..409
FT /note="VPFFLTWSVVNSVHWANGSTQALPA -> EFLSVTQCGELSALGQRFNTGAA
FT T (in Ref. 1; AAF98161)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 606 AA; 68928 MW; 1DDB125FA81EC47B CRC64;
MTVLGYPRSW SCHCLPVLIL LLGIGHGPWV EGVTHYKPGD PVILYVNKVG PYHNPQETYH
YYQLPVCCPE KIRHKSLSLG EVLDGDRMAE SLYEIRFREN VEKRILCHMQ LSSAQVEQLR
QAIEELYYFE FVVDDLPIRG FVGYMEESGF LPHSHKIGLW THLDFHLEFH GDRIIFANVS
VRDVKPHSLD GLRSDELLGL THTYSVRWSE TSVEHRSDRR RGDDGGFFPR TLEIHWLSII
NSMVLVFLLV GFVAVILMRV LRNDLARYNL DEETSSGGSS DDFDQGDNGW KIIHTDVFRF
PPYRGLLCAV LGVGAQFLAL GTGIIVMALL GMFNVHRHGA INSAAILLYA LTCCISGYVS
SHFYRQIGGE RWVWNIILTS SLFSVPFFLT WSVVNSVHWA NGSTQALPAT TILLLLTVWL
LVGFPLTVIG GIFGKNNASP FDAPCRTKNI AREIPPQPWY KSTVIHMTVG GFLPFSAISV
ELYYIFATVW GREQYTLYGI LFFVFAILLS VGACISIALT YFQLSGEDYR WWWRSVLSVG
STGLFIFLYS VFYYARRSNM SGAVQTVEFF GYSLLTGYVF FLMLGTISFF SSLKFIRYIY
VNLKMD
